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Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis

International Journal of Ophthalmology(English edition) 2017年第6期10卷 973-981页

作者： Qing-Yang Feng Zi-Xuan Hu Xi-Ling Song Hong-Wei Pan[[ Department of Ophthalmology the First Affiliated Hospital of Jinan University Guangzhou 510630 Guangdong Province China Department of Public Health and Preventive Medicine Jinan University Guangzhou 510632 Guangdong Province China Institute of Ophthalmology School of Medicine Jinan University Guangzhou 510632 Guangdong Province China

Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of mefalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.

关键词： pterygium growth factors matrixmetalloproteinases tissue inhibitors of metalloproteinases interleukins tumor suppressor genes proliferation andapoptosis cell adhesion molecules extmcellular matrix proteins

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