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The Role of Host-derived Dentinal matrix metalloproteinases in Reducing Dentin Bonding of Resin Adhesives

International Journal of Oral Science 2009年第4期1卷 163-176页

作者： Matthias Kern Department of Prosthodontics Propaedeutics and Dental Materials Christians-Albrechts UniversityKiel Germany

Dentin matrix metalloproteinases （mmps） are a family of host-derived proteolytic enzymes trapped within mineralized dentin matrix, which have the ability to hydrolyze the organic matrix of demineralized dentin. After bonding with resins to dentin there are usually some exposed collagen fibrils at the bottom of the hybrid layer owing to imperfect resin impregnation of the demineralized dentin matrix. Exposed collagen fibrils might be affected by mmps inducing hydrolytic degradation, which might result in reduced bond strength.Most mmps are synthesized and released from odontoblasts in the form of proenzymes, requiring activation to degrade extracellular matrix components. Unfortunately, they can be activated by modem self-etch and etch-and-rinse adhe- sives. The aim of this review is to summarize the current knowledge of the role of dentinal host-derived mmps in dentin matrix degradation. We also discuss various available MMP inhibitors, especially chlorhexidine, and suggest that they could provide a potential pathway for inhibiting collagen degradation in bonding interfaces thereby increasing dentin bonding durability.

关键词： bonding matrix metalloproteinases（mmps） MMP inhibitors chlorhexidine

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Inhibitory Effects of Polygoni Multiflori Caulis Extracts on matrix Metalloproteinase Activities

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Chemical Research in Chinese Universities 2009年第2期25卷 211-215页

作者： LIU Jun-song YANG Jin-gang HONG Yuan JIN Feng-hai WANG Ming-cui ZHAO Shu-hua FANG Xue-xun Key Laboratory of Molecular Enzymology and Enzyme Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China College of Life Science Jilin University Changchun 130012 P. R. China College of Medicine Jilin University Changchun 130021 P. R. China Department of Traditional Chinese Medicine China-Japan Union Hospital Jilin University Changchun 130033 P. R. China State key Laboratory of Superhard Materials Jilin University Changchun 130012 P. R. China

matrix metalloproteinases（mmps） play an essential role in development and tissue remodeling of living organisms. However, the overexpression of mmps has lead to a series of diseases, such as cancer, arthritis, and atherosclerosis; and inhibition of mmps may have therapeutic benefits. The discovery of MMP inhibitors from herbal has become a prospective event. We showed that the extract of Polygoni multiflori caulis from ethyl acetate or water（ethyl acetate extract and water extract） can inhibit the activities of mmps 9, 14, and 16 in a dose-dependent manner and n-butyl alcohol extract of it can also inhibit these mmps. Furthermore, we found that n-butyl alcohol extract and water extract of it influence the cell viability. These discoveries may contribute to the development of MMP in- hibitors for the therapy of a variety of pathological conditions.

关键词： matrix metalloproteinases（mmps） Polygoni multi/lori caulis Water extract Cell viability assay

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