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Endostatin promotes the anabolic program of rabbit chondrocyte

Cell Research 2005年第3期15卷 201-206页

作者： Yi FENG,Yi Pin WU,Xu Dong ZHU,Yan Hong ZHANG,Qing Jun MA* Department of Molecule Genetics,Beijing Institute of Biotechnology,27 Taiping Road,Beijing 100850,China Department of Molecule Genetics Beijing Institute of Biotechnology Beijing China

Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism.

关键词： endostatin angiogenesis chondrocyte matrix metalloproteinase.

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Comparative study on the effect of integrin αvβ3 on secretion of matrix metalloproteinase. in human normal and carcinoma trophoblasts

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Progress in Natural Science:Materials International 2005年第11期15卷 982-987页

作者： BAI Suxia, FU Yayuan, KONG Gang and WANG Yanling (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China The Second Hospital of Chinese Medicine College, Shenyang 110003, China) State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100080 China The Second Hospital of Chinese Medicine College Shenyang 110003 China

The invasion of cytotrophoblast cells into the maternal endometrium during embryonic implantation is very similar to the metastasis of carcinoma cells. However, the significant difference is that the former is a highly controlled process. In this report, the effects of integnn αvβ3 on the secretion of matrix metalloproteinase.(MMP) were compared between normal cytotrophoblast cells and chorio-carcinoma cells by RT-PCR, gelatin zymography and immunocytochemistry. The results reveal that both normal cytotrophobiast cells and choriocarcinoma cells can express integrin αvβ3. The secretion of MMPs in normal cytotrophoblast cells is up-regulated by anti-αvβ3 antibody, whereas, decreased in choriocarcmoma cells. It was suggested that αvβ3 can modulate the expression of MMPs in trophoblasts, and this action is carried out through distinct mechanisms in normal and carcinoma cytotrophoblast cells.

关键词： cytotrophoblast cells choriocarcinoma cells integrfn αvβ3 matrix metalloproteinase.

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