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Journal of materiomics

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硅酸盐学报 2020年第1期48卷 148-148页

Indexed by SCI and Scopus(Cite Score 8.02)The Journal of materiomicsaims to provide a continuous forum for the dissemination of research in the general field of materials science,particularly systematic studies of the... 详细信息

关键词： materiomics dissemination materials science

Journal of materiomics

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硅酸盐学报 2020年第4期48卷 616-616页

Indexed by SCI and Scopus (Cite Score 8.02)The Journal of materiomicsaims to provide a continuous forum for the dissemination of research in the general field of materials science, particularly systematic studies of t... 详细信息

Indexed by SCI and Scopus (Cite Score 8.02)The Journal of materiomicsaims to provide a continuous forum for the dissemination of research in the general field of materials science, particularly systematic studies of the relationships among composition, processing, structure, property, and performance of advanced materials.

关键词： Scopus Journal of materiomics

Compressive deformation of ultralong amyloid fibrils

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Acta Mechanica Sinica 2010年第6期26卷 977-986页

作者： Raffaella Paparcone Steven Cranford Markus J.Buehler Laboratory for Atomistic and Molecular Mechanics

Involved in various neurodegenerative diseases, amyloid fibrils and plaques feature a hierarchical structure, ranging from the atomistic to the micrometer *** the atomistic level,a dense and organized hydrogen bond network is resembled in a beta-sheet rich secondary structure, which drives a remarkable stiffness in the range of 10-20GPa,larger than many other biological nanofibrils, a result confirmed by both experiment and ***, the understanding of how these exceptional mechanical properties transfer from the atomistic to the nanoscale remains *** we report a multiscale analysis that, from the atomistic-level structure of a single fibril,extends to the mesoscale level,reaching size scales of hundreds of *** use parameters directly derived from full atomistic simulations of Aβ（1-40） amyloid fibrils to parameterize a mesoscopic coarse-grained model,which is used to reproduce the elastic properties of amyloid *** then apply our mesoscopic model in an analysis of the buckling behavior of amyloid fibrils with different lengths and report a comparison with predictions from continuum beam theory. An important implication of our results is a severe reduction of the effective modulus due to buckling,an effect that could be important to interpret experimental results of ultralong amyloid *** model represents a powerful tool to mechanically characterize molecular structures on the order of hundreds of nanometers to micrometers on the basis of the underlying atomistic *** work provides insight into structural and mechanical properties of amyloid fibrils and may enable further analysis of larger-scale assemblies such as amyloidogenic bundles or plaques as found in disease states.

关键词： Amyloid Coarse-grain Molecular simulation Nanomechanics materiomics

MULTISCALE MECHANICS OF BIOLOGICAL AND BIOLOGICALLY INSPIRED MATERIALS AND STRUCTURES

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Acta Mechanica Solida Sinica 2010年第6期23卷 471-483页

作者： Markus J.Buehler Laboratory for Atomistic and Molecular Mechanics Department of Civil and Environmental EngineeringMassachusetts Institute of Technology Center for Computational Engineering Massachusetts Institute of Technology Center for Materials Science and Engineering Massachusetts Institute of Technology

The world of natural materials and structures provides an abundance of applications in which mechanics is a critical issue for our understanding of functional material properties. In particular, the mechanical properties of biological materials and structures play an important role in virtually all physiological processes and at all scales, from the molecular and nanoscale to the macroscale, linking research fields as diverse as genetics to structural mechanics in an approach referred to as materiomics. Example cases that illustrate the importance of mechanics in biology include mechanical support provided by materials like bone, the facilitation of locomotion capabilities by muscle and tendon, or the protection against environmental impact by materials as the skin or armors. In this article we review recent progress and case studies, relevant for a variety of applications that range from medicine to civil engineering. We demonstrate the importance of fundamental mechanistic insight at multiple time- and length-scales to arrive at a systematic understanding of materials and structures in biology, in the context of both physiological and disease states and for the development of de novo biomaterials. Three particularly intriguing issues that will be discussed here include： First, the capacity of biological systems to turn weakness to strength through the utilization of multiple structural levels within the universality-diversity paradigm. Second, material breakdown in extreme and disease conditions. And third, we review an example where the hierarchical design paradigm found in natural protein materials has been applied in the development of a novel hiomaterial based on amyloid protein.

关键词： biological materials materiomics mechanics mechanical properties mutability,tunability deformation failure

Elasticity,Strength and Resilience:A Comparative Study on Mechanical Signatures ofα-Helix,β-Sheet and Tropocollagen Domains

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Nano Research 2008年第1期1卷 63-71页

作者： Markus J.Buehler Sinan Keten Laboratory for Atomistic and Molecular Mechanics Department of Civil and Environmental EngineeringMassachusetts Institute of Technology77 Massachusetts Ave.Room 1-235 A&BCambridgeMA02139-4307USA

In biology,structural design and materials engineering is unified through formation of hierarchical features with atomic resolution,from nano to *** molecular building blocks are particularly prevalent in all structural protein materials:alpha helices(AHs),beta-sheets(BSs)and tropocollagen(TC).In this article we present a comparative study of these three key building blocks by focusing on their mechanical signatures,based on results from full-atomistic simulation *** fi nd that each of the basic structures is associated with a characteristic material behavior:AH protein domains provide resilience at large deformation through energy dissipation at low force levels,BS protein domains provide great strength under shear loading,and tropocollagen molecules provide large elasticity for deformation *** suggests that AHs,BSs,and TC molecules have mutually exclusive mechanical *** correlate each of these basic properties with the molecule’s structure and the associated fundamental rupture *** study may enable the use of abundant protein building blocks in nanoengineered materials,and may provide critical insight into basic biological mechanisms for bio-inspired *** transfer towards the design of novel nanostructures could lead to new multifunctional and mechanically active,tunable,and changeable materials.

关键词： Fracture biology hierarchical materials materiomics proteins self-assembly mechanical properties theory strength