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Evaluation of fatigue and rutting properties of asphalt binderand mastic modified by synthesized polyurethane

Journal of Traffic and Transportation Engineering(English Edition) 2021年第6期8卷 1036-1048页

作者： Mana Motamedi Gholamali Shafabakhsh Mohammad Azadi Faculty of Civil Engineering Semnan UniversitySemnan 35131-19111Iran Faculty of Mechanical Engineering Semnan UniversitySemnan 35131-19111Iran

Fatigue and rutting phenomena are major distresses in asphalt *** mixture properties are highly dependent upon the asphalt binder and the mastic *** purpose of this study was to investigate the behavior of the asphalt binder and the mastic,modified by the synthesized polyurethane,at high and intermediate *** filler/asphalt binder ratio(by weight)was *** dynamic shear rheometer(DSR)was used to measure fatigue(G^(*)sinδ)and rutting(G^(*)/sinδ)*** this study,the multiple stress creepandrecovery(MSCR)testwasalso utilizedto calculate the ruttingpotential of theasphalt binder and *** of the non-recoverable compliance(Jnr)and the percentage recovery(%)were evaluated at high *** obtained results indicated that the synthesizedpolyurethaneimproved the ruttingandfatigue *** significant correlation between the asphalt binder and the mastic in terms of the complex modulus(R^(2)=0.9958),rutting(R^(2)=0.9944),and the non-recoverable compliance(R^(2)=0.9707).For the fatigue parameter(R^(2)=0.9852),the complex modulus(R^(2)=0.9855),and the phase angle(R^(2)=0.8262),significant relationships were observed between the asphalt binder and mastic samples at intermediate ***,the chemical reaction between the filler and the asphalt binder could be effective in different behaviors of the mastic and asphalt *** 112%-164%increase in the G^(*)sinδparameter formastics,compared to that of the asphalt *** complex modulus was 6 times higher by adding the filler content.

关键词： Road engineering Polyurethane Asphalt binder mastic Rutting resistance Fatigue parameter

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Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic

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World Journal of Gastroenterology 2007年第45期13卷 6031-6036页

作者： Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos Department of Science of Dietetics-Nutrition Harokopio University Athens Greece Department of Gastroenterology Saint Panteleimon General State Hospital Nicea Athens Greece

AIM： To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn＇s disease （CD）. METHODS： The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps （6 caps/d, 0.37 g/cap） were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 （IL-6）, tumor necrosis factor-alpha （TNF-α）, monocyte chemotactic protein-1 （MCP-1）, macrophage migration inhibitory factor （MIF） and intracellular antioxidant glutathione （GSH） were evaluated in peripheral blood mononuclear cells （PBMC） before and after treatment. RESULTS： Treating CD patients with mastic resulted in the reduction of TNF-α secretion （2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028）. MIF release was significantly increased （1.2±0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026） meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No significant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION： This study shows that mastic acts as an immunomodulator on PBIC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this finding provides strong evidence that mastic might be an important regulator of immunity in CD.

关键词： mastic Crohn's disease Inflammatorycytokines Glutathione Immunomodulation Conservativetreatment

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Evaluation of gum mastic(Pistacia lentiscus) as a microencapsulating and matrix forming material for sustained drug release

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 424-432页

作者： Dinesh M.Morkhade Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur University Campus

In this study, a natural gum mastic was evaluated as a microencapsulating and matrixforming material for sustained drug release. mastic was characterized for its physicochemical properties. Microparticles were prepared by oil-in-oil solvent evaporation method. Matrix tablets were prepared by wet and melt granulation techniques. Diclofenac sodium(DFS) and diltiazem hydrochloride(DLTZ) were used as model drugs. mastic produced discrete and spherical microspheres with DLTZ and microcapsules with DFS. Particle size and drug loading of microparticles was in the range of 22–62 μm and 50–87%, respectively. Increase in mastic:drug ratio increased microparticle size, improved drug loading and decreased the drug release rate. Microparticles with gum: drug ratio of 2:1 could sustain DLTZ release up to 12 h and released 57% DFS in 12 h. mastic produced tablets with acceptable pharmacotechnical properties. A 30% w/w of mastic in tablet could sustain DLTZ release for 5 h from wet granulation,and DFS release for 8 h and 11 h from wet and melt granulation, respectively. Results revealed that a natural gum mastic can be used successfully to formulate matrix tablets and microparticles for sustained drug release.

关键词： Gum mastic Diclofenac sodium Diltiazem hydrochloride Microparticles Matrix tablets Sustained release

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Fatigue of asphalt binder,mastic and mixture at low temperature

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Frontiers of Structural and Civil Engineering 2012年第2期6卷 166-175页

作者： Dong WANG Linbing WANG Guoqing ZHOU Virginia Tech Transportation Institute Blacksburg VA 24061USA The Via Department of Civil and Environmental Engineering Virginia Polytechnic Institute and State UniversityBlacksburg VA 24061USA Guangxi Key Laboratory for Spatial Information Guilin University of TechnologyGuilin 541004China

The fatigue damage is one of the most common distresses observed on the asphalt concrete *** thoroughly understand the fatigue of asphalt concrete,the behaviors of the major components of asphalt concrete under cyclic loading are investigated respectively in this study.A new experiment method is developed to evaluate the performances of asphalt binder,mastic and fine aggregates mixture under cyclic tensile *** fatigue test results of asphalt binder show that the fatigue performance of asphalt binder is closely related with loading magnitude,temperature and loading *** specimens with different filler content are tested and the results indicate that mastic specimens with 30%filler content show better fatigue resistance and higher permanent *** micro-structure analysis of mastic and mixture indicates that the fatigue resistance is closely related with the air void content of specimen.3D digital specimens are developed to model the fatigue of the asphalt binder,mastic and mixture specimens based on the finite element method(FEM).Fatigue damage of asphalt concrete is simplified by a damage *** proper selection of damage parameters,the simulation results agree well with laboratory test results and can be used as a basis for future fatigue research.

关键词： fatigue asphalt mixture asphalt binder mastic finite element method(FEM) X-ray tomography

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Stabilizing Effects of Ethanolic Extract of mastic Gum on Microtubule Polymers:an In Vitro Study

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Journal of Human Physiology 2019年第2期1卷 18-25页

作者： Ali Dadras Fatemeh Shahrokhi Asl Gholam Hossein Riazi Shahin Ahmadian Tahereh Javdani Khalife Neuro-organic Lab Institute of Biochemistry and Biophysics(IBB)University of TehranTehranIran

Terpenoids are novel natural products isolated from mastic *** gum was obtained from the Pistacia Lentiscus *** investigations have documented medical and pharmacological properties of mastic gum such as memory enhancement,antifungal,and antibacterial *** was astonishing to study the possible interaction of mastic gum extract with microtubule proteins which are involved in memory and consciousness since the administration of mastic gum is evidenced in the improvement of brain *** a number of studies have demonstrated the effect of microtubule dynamics on mammals'memory,in this study,we investigated the effect of Oxygenated Sesquiterpenes(OST)on microtubule polymerization in *** was purified from the ethanolic extract of mastic *** results revealed that OST induces microtubule polymerization;however,microtubule depolymerization was not affected and fluorometric assays showed conformational changes of tubulin in the presence of *** interestingly found that colchicine was unable to inhibit MT assembly in the presence of OST and OST was solely more efficient than the combination of OST with paclitaxel for elevating microtubule polymerization *** hope that OST could be a promising agent for memory enhancement and the treatment of neurodegenerative diseases as a novel tubulin-binding compound.

关键词： Pistacia lentiscus mastic gum Oxygenated Sesquitrepene(OST) Tubulin Microtubule

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