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Acetylcholinesterase inhibitors and antioxidants mining from marine fungi:bioassays,bioactivity coupled LC-MS/MS analyses and molecular networking

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marine Life Science & Technology 2020年第4期2卷 386-397页

作者： Yingying Nie Wencong Yang Yayue Liu Jingming Yang Xiaoling Lei William HGerwick Yi Zhang Center for marine Drugs Research and Development Shenzhen Institute of Guangdong Ocean UniversityShenzhen 518000China College of Food Science and Technology Key Laboratory of Guangdong Province Aquatic Products Processing and SafetyGuangdong Province Engineering Laboratory for Marine Biological ProductsGuangdong Provincial Engineering Technology Research Center of Marine FoodKey Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education InstitutionZhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain HealthResearch Institute for Marine Drugs and NutritionGuangdong Ocean UniversityZhanjiang 52408&China Center for marine Biotechnology and Biomedicine Scripps Institution of OceanographyUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

marine fungi are potentially important resources for bioactive lead compounds for discovering new drugs for diseases such as Alzheimer's disease.In this paper,the combined bioassay model of acetylcholinesterase(AChE)inhibition,1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging,and Artemi ci larval lethality was used to evaluate the activity and toxicity of 35 n narine fun gal strains from seas around China.Their bioactive constitue nfs were revealed by thin layer chromatography(TLC)autography,bioactivity coupled LC-MS/MS and Global Natural Products Social Molecular Networking(GNPS).The results show that the extracts of five strains exhibited higher AChE inhibition ratios than the positive control compound,'tacrine;for which the ratio was 89.8%at 200 pig/ml.Six strains displayed both AChE inhibition(inhibition ratios>20%at 200 pg/ml)and DPPH scavenging activity(scavenging ratios>30%at 200 pg/ml)together with low Artemia larval toxicity(lethal rates<12%).TLC autography showed that the fractioned extracts of four strains contained highly diverse and different bioactive constituents,includi ng strains Talaromyces sp.C2\-\,Aspergillus ter re us C23-3,Trichoderma harzianum DLEN2008005,and Penicillium corylophilum TBG1-17.From the most potent sample F-l 1-1-b(derived from Aspergillus tern us C23-3),five AChE inhibitors and seven antioxida nts were recognized as bioactive molecules by AChE coupled ultrafiltration followed by LC-MS/MS,and LC-MS/MS coupled with DPPH incubation.Furthermore,with the aid of GNPS,the AChE inhibitors were plausibly annotated as territrem analogues including territrems A-C/D,arisugacin A and an unknown compound 4,and the seven antioxidants were assigned as butyrolactone I.aspernolide E,a phenolic derivative and possibly unknown compounds 8-10 and 12.

关键词： Acetylcholinesterase inhibition Antioxida marine fungi LC-MS/MS Molecular networking

Hidden diversity of marine borderline lichens and a new order of fungi:Collemopsidiales(Dothideomyceta)

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Fungal Diversity 2016年第5期80卷 285-300页

作者： Sergio Pérez-Ortega Isaac Garrido-Benavent Martin Grube Rocío Olmo Asunción de los Ríos Museo Nacional de Ciencias Naturales(CSIC) Serrano 115 dpdoE-28006 MadridSpain Real Jardín Botánico de Madrid(CSIC) Plaza Murillo 2E-28014 MadridSpain Institute of Plant Sciences University of GrazHolteigasse 6A-8010 GrazAustria Facultad de Ciencias Ambientales y Bioquímica Universidad de Castilla-La ManchaAvenida de Carlos III s/n45071 ToledoSpain

The fungal genus Collemopsidium comprises species that develop so-called borderline lichen symbioses with algae or cyanobacteria.Together with morphologically similar pyrenocarpous fungi it has been assigned to the family Xanthopyreniaceae.The adscription of this family to higher taxonomic ranks remain uncertain.Using sequence data of five nuclear genomic regions(nuLSU,nuSSU,tef1-α,rpb1 and rpb2)and onemitochondrial locus(mtSSU)we found that the studied representatives of this family are placed in the Dothideomyceta,yet relationships with the classes Dothideomycetes and Arthoniomycetes remain uncertain.We describe the new order Collemopsidiales to accommodate the genus Collemopsidium(paraphyletic as currently understood)and the lichenicolous genus Zwackhiomyces.Using five fungal fossils as calibrations points,we infer an age of c.230 Mya for the crown of Collemopsidiales.Based on two molecular markers,we also provide insight into the global diversity of marine species of the genus Collemopsidium.According to the species delimitation algorithm GMYC,c.26 putative species exist,far more than the six species recognized hitherto.We have confirmed this result by comparing the two alternative species models by means of Bayes factors,using path sampling and stepping-stone sampling algorithms to estimate the marginal likelihood of each model.Finally,our observations suggest rock-boring ability evolved in parallel in the different lineages within this group of fungi.

关键词： Borderline lichens Dothideomycetes Endolithics.Lichen-forming fungi Lichenicolous fungi Boring ability marine fungi Model comparison

β-cyclopiazonic acid binds iron demonstrating siderophorelike activity and promotes growth in Pseudomonas aeruginosa

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Journal of Oceanology and Limnology 2023年第3期41卷 1159-1167页

作者： Yuqi GUO Youmin YING Qihao WU Bin WEI Jianwei CHEN Hong WANG College of Pharmaceutical Science&Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

This chemical study reports a novel siderophore-like compound,β-cyclopiazonic acid(1,β-CPA)extracted from marine fungus Aspergillus flavus.The chemical structure ofβ-CPA was elucidated by a combination of extensive spectroscopic analyses and TDDFT-ECD calculations.The iron-binding ability and CAS assays demonstrate thatβ-CPA is a novel siderophore that features a different chemical structure from those of traditional siderophores.Theβ-CPA has no obvious influence on the growth of bacterium Pseudomonas aeruginosa PAO1.However,its iron chelator could promote the growth of P.aeruginosa PAO1,suggesting that P.aeruginosa employed siderophores to sequester iron,which is vital for their survival.The study provides the physiochemical evaluation ofβ-CPA,an unusual skeletonstructure siderophore,which for the first time,was proven to have the ability to bind iron and affect P.aeruginosa growth.This new discovery of siderophore provides an opportunity for developing novel anti-P.aeruginosa drugs.

关键词： marine fungi β-cyclopiazonic acid siderophore Pseudomonas aeruginosa

Occurrence and geographical distribution of mangrove fungi

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Fungal Diversity 2021年第1期106卷 137-227页

作者： B.Devadatha E.B.G.Jones K.L.Pang M.A.Abdel-Wahab K.D.Hyde J.Sakayaroj A.H.Bahkali M.S.Calabon V.V.Sarma S.Sutreong S.N.Zhang Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia Institute of marine Biology and Centre of Excellence for the Oceans National Taiwan Ocean University2 Pei-NingRoadKeelung 20224TaiwanROC Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt School of Science Walailak University222 ThaiburiThasala DistrictNakhon Si Thammarat 80161Thailand Department of Biotechnology School of Life SciencesPondicherry UniversityKalapetPondicherry 605014India National Biobank of Thailand(NBT) National Science and Technology Development Agency(NSTDA)111 Thailand Science ParkThanon PhahonyothinTambon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand

This is a multidimensional review of mangrove fungi occurring as saprobes,pathogens and endophytes of a wide range of host substrates and those isolated from the water columns and sediments in mangroves.Eight-hundred and fifty taxa including 658 that are supported by both morphology and molecular data and 192 with only morphological data are listed.These constitute Ascomycota,the dominant group with 773 species,and 58 Basidiomycota,one Blastocladiomycota,five Chytridiomycota,and 13 Mucoromycota.This study also includes data on mangrove yeasts 103 Ascomycota,39 Basidi-omycota and 193 taxa isolated from sediments.Endophytes isolated from submerged parts of mangrove plants total 38.The most specious orders of mangrove fungi are Pleosporales 133,Saccharomycetales 102,Microascales 101,Eurotiales 87,Hypocreales 60 and Xylariales 54.Speciose genera include Candida 39,Aspergillus 53,Penicillium 17 and Corollospora 16.The highest number of mangrove fungi have been recorded from the Pacific Ocean 553,which is the largest ocean,followed by Indian 408 and Atlantic Oceans 259.Geographical distribution of mangrove fungi varied from ocean to ocean with only 109 taxa common to the Atlantic,Indian and Pacific Oceans.Of the various countries reported for mangrove fungi,India accommodates the highest number(339)followed by Thailand 303,Malaysia 171,Florida Everglades,USA 134 and Brunei 134.A total of 60 different mangrove plants and their associates have been surveyed for mangrove fungi.These results are discussed and compared with previous studies.

关键词： Host preference marine ecology marine fungi World distribution

Classification of marine Ascomycota,Basidiomycota,Blastocladiomycota and Chytridiomycota

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Fungal Diversity 2015年第4期73卷 1-72页

作者： E.B.Gareth Jones Satinee Suetrong Jariya Sakayaroj Ali H.Bahkali Mohamed A.Abdel-Wahab Teun Boekhout Ka-Lai Pang Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Fungal Biodiversity Laboratory BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Department of Botany Faculty of ScienceSohag UniversitySohagEgypt CBS Fungal Biodiversity Centre(KNAW) Uppsalalaan 83584CT UtrechtThe Netherlands Institute of marine Biology and Center of Excellence for the Oceans Taiwan Ocean University2 Pei-Ning RoadKeelung 20224TaiwanRepublic of China

This paper lists the accepted names and classification of marine fungi,updating the scheme presented in 2009.The classification includes 1,112 species(in 472 genera):Ascomycota 805(in 352 genera),Basidiomycota 21 species(in 17 genera),Chytridiomycota and related phyla 26 species(in 13 genera),Zygomycota three(in two genera),Blastocladiomycota one species(one genus),asexual morphs of filamentous fungi 43(in 26 genera);and marine yeasts:Ascomycota 138 species(in 35 genera),Basidiomycota 75 species(in 26 genera).These fungi belong to 129 families and 65 orders.The Halosphaeriaceae remains the largest family of marine fungi with 141 species in 59 genera,while the most specious genera are Aspergillus(47 species),Penicillium(39 species)and the yeast genus Candida(64 species).The review includes details of recent higher order nomenclature changes,and accounts of new families,genera and species described over the past 5 years.

关键词： Fungal classification marine fungi Molecular phylogeny New taxa Praelongicaulis gen nov Tirisporellales Torpedosporales ordo nov

Multi-gene phylogeny of Jattaea bruguierae,a novel asexual morph from Bruguiera cylindrica

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Studies in fungi 2017年第1期2卷 235-245页

作者： Dayarathne MC Abeywickrama P Jones EBG Bhat DJ Chomnunti P Hyde KD Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai57100Thailand Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry Sciences Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India Formerly Department of BotanyGoa UniversityGoa 403206India

During our survey on marine-based ascomycetes of southern Thailand,fallen mangrove twigs were collected from the intertidal zones.Those specimens yielded a novel asexual morph of Jattaea(Calosphaeriaceae,Calosphaeriales),Jattaea bruguierae,which is confirmed as a new species by morphological characteristics such as nature and measurements of conidia and conidiophores,as well as a multigene analysis based on combined LSU,SSU,ITS andβ-tubulin sequence data.Jattaea species are abundantly found from wood in terrestrial environments,while the asexual morphs are mostly reported from axenic cultures.Jattaea bruguierae is the first documentation of an asexual morph species from marine-habitats.

关键词： marine fungi morphology phylogeny taxonomy

Fungal species consortia on Nypa fruticans at Brunei

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Studies in fungi 2018年第1期3卷 19-26页

作者： Sarma VV Hyde KD Centre for Research in Fungal Diversity Department of Ecology and BiodiversityThe University of Hong KongPokfulam RoadHong KongChina Department of Biotechnology School of Life SceincesPondicherry UniversityKalapetPondicherry-605014India School of Science Mae Fah Luang UniversityChiang RaiThailand

Studies on fungal species consortia of manglicolous fungi are very few.Observations of fungal species consortia may provide an idea on the fungal community structures and help in understanding ecosystem dynamics.In this paper,the fungal species consortia recorded on Nypa fruticans at Brunei is presented.Astrosphaeriella striatispora,Linocarpon appendiculatum,L.bipolaris,Neolinocarpon globosicarpa,Oxydothis nypae and Trichocladium nypae,were the frequently recorded fungi in this study.Three distinct fungal assemblages were found.One of these assemblages was typified by Astrosphaeriella striatispora,Linocarpon nypae and Oxydothis nypae in which the fungi occurred both in association with others as well as singly indicating a commensalistic occurrence.The second assemblage,was characterized by Linocarpon appendiculatum and Linocarpon bipolaris,the fungi occurred almost only in association with others,indicating a mutualistic behavior.The third assemblage was characterized by Anthostomella eructans,Anthostomella sp.and Trichocladium sp.which always occurred singly,indicating a possible antagonistic life style but the percentage occurrence of the last group was far low to attribute any antagonistic potential of these fungi in preventing other fungi from colonization.

关键词： co-occurrence ecology interactions mangroves marine fungi

Secondary Metabolites from marine-Derived Fungus Eurotium sp.SCSIO F452

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Secondary Metabolites from Marine-Derived Fungus Eurotium sp...

中国化学会第十二届全国天然有机化学学术会议

作者： Wei-Mao Zhong Qi Zeng Yao Xiang Xia-Yu Chen Fa-Zuo Wang Si Zhang CAS Key Laboratory of Tropical marine Bio-resources and Ecology RNAM Center for Marine MicrobiologyGuangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of Sciences University of Chinese Academy of Sciences

marine-derived fungi have been proven to be a prolific source of structurally diverse and biologically active natural products,including polyketides,alkaloids,meroterpenoids,and cyclic peptides.These compounds exhibit various biological activities such as antibacterial,antitumor,antiviral,and antiinflammatory.In the course of our continuing investigation on marine fungi,a further chemical investigation was performed on Eurotium sp.SCSIO F452,a South China Sea sediment derived fungus found to be producing diketopiperazine alkaloids and polyketides.Carefully chemical examination led to the isolation and characterization of compounds 1-7(Figure 1).Their structures were elucidated as eurotiumin F(1),2-(2,3-epoxy-1-heptenyl)-6-hydroxy-5-(3-methyl-2-butenyl)benzaldehyde(2),2-(2,3-epoxy-1,3-heptadienyl)-6-hydroxy-5-(3-methyl-2-butenyl)benzaldehyde(3),flavoglaucin(4),2-(E-3-heptneyl)-3,6-dihydroxy-5-(3-methyl-2-butenyl)-benzaldehyde(5),isotetrahydroauroglaucin(6),and dihydroauroglaucin(7) by comprehensive spectroscopic methods.The new compound 1 was evaluated for its cytotoxic activity against SF-268 and HepG2 cell lines with SRB method and didn’t showed activity(IC>100μM).

关键词： marine fungi Secondary metabolites Cytotoxic activity

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