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mannose inhibits the growth of prostate cancer through a mitochondrial mechanism

Asian Journal of Andrology 2022年第5期24卷 540-548页

作者： Yu-Lin Deng Ren Liu Zhou-Da Cai Zhao-Dong Han Yuan-Fa Feng Shang-Hua Cai Qing-Biao Chen Jian-Guo Zhu Wei-De Zhong Guangdong Provincial Institute of Nephrology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Andrology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Department of Urology Guangdong Key Laboratory of Clinical Molecular Medicine and DiagnosticsGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Urology Key Laboratory of Guangdong Province The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510230China Department of Urology Guizhou Provincial People’s HospitalThe Affiliated Hospital of Guizhou Medical UniversityGuiyang 550002China Department of Urology Surgery Affiliated Foshan Hospital of Southern Medical UniversityFoshan 528000China

The limited treatment options for advanced prostate cancer(PCa)lead to the urgent need to discover new anticancer ***,an isomer of glucose,has been reported to have an anticancer effect on various ***,the anticancer effect of mannose in PCa remains *** this study,we demonstrated that mannose inhibits the proliferation and promotes the apoptosis of PCa cells in vitro,and mannose was observed to have an anticancer effect in mice without harming their *** of intracellular mannose simultaneously decreased the mitochondrial membrane potential,increased mitochondrial and cellular reactive oxygen species(ROS)levels,and reduced adenosine triphosphate(ATP)production in PCa *** treatment of PCa cells induced changes in mitochondrial morphology,caused dysregulated expression of the fission protein,such as fission,mitochondrial 1(FIS1),and enhanced the expression of proapoptotic factors,such as BCL2-associated X(Bax)and BCL2-antagonist/killer 1(Bak).Furthermore,lower expression of mannose phosphate isomerase(MPI),the key enzyme in mannose metabolism,indicated poorer prognosis in PCa patients,and downregulation of MPI expression in PCa cells enhanced the anticancer effect of *** study reveals the anticancer effect of mannose in PCa and its clinical significance in PCa patients.

关键词： mannose mannose phosphate isomerase metabolism mitochondria prostate cancer

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