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Two new diterpenoids from the endophytic fungus Trichoderma sp.Xy24 isolated from mangrove plant Xylocarpus granatum

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Chinese Chemical Letters 2016年第6期27卷 957-960页

作者： Min Zhang Ji-Mei Liu Jin-Lian Zhao Ning Li Ri-Dao Chen Ke-Bo Xie Wen-Jing Zhang Ke-Ping Feng Zheng Yan Nan Wang Jun-Gui Dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Two new harziane diterpenoids, named（9R,10R）-dihydro-harzianone（1） and harzianelactone（2）, were isolated from the endophytic fungus Trichoderma sp. Xy24 by using various column chromatography techniques. Their structures were determined on the basis of extensive spectroscopic（HR-ESI-MS, 1D NMR, 2D NMR and CD） analyses. Among them, 1 was the reductive product of harzianone and 2 was the Baeyer–Villiger monooxygenase catalyzed oxidation product of harzianone. Compound 1 exhibited cytotoxic activity against He La and MCF-7 cell lines with IC（50） values of 30.1 μmol/L and 30.7 μmol/L,respectively.

关键词： Harziane diterpenoids Trichoderma sp.Xy24 Endophytic fungus mangrove plant Cytotoxic activity

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Triterpenoids from the mangrove plant Sonneratia Paracaseolaris and Their Bioactivities

Triterpenoids from the Mangrove Plant Sonneratia Paracaseola...

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2013年中国药学大会暨第十三届中国药师周

作者： Kai-Kai Gong Ping-Lin Li Xing-Wang Zhang Nai-Xia Zhang Lei Xue Wen-Juan Song Xu-Li Tang Guo-Qiang Li Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China College of Chemistry and Chemical Engineering Ocean University of China

Chemical investigation of the aerial parts of mangrove plant Sonneratia Paracaseolaris yielded five new triterpenoids paracaseolins A E （1 4, and 11） together with twelve known ones （5 10, 12 17）. Their structures were established by extensive spectroscopic methods and comparison of their spectroscopic data with those of the related known compounds. The cytotoxicities against P388, HeLa, A549 and K562 tumor cell lines and anti-H1N1 （Influenza A virus） activities for the isolates were evaluated. Compound 4 showed potent cytotoxicity against A549 cell line with IC 50 value of 1.89 M. A preliminary SAR was discussed, and the 3 -coumaroyl group was suggested as an essential pharmacophore for their cytotoxicities against P388, HeLa and A549 cell lines. Besides, compound 1 exhibited significant anti-H1N1 virus activity with IC 50 value of 28.4 g/mL.

关键词： mangrove plant Sonneratia Paracaseolaris Sonneratiaceae triterpenoids cytotoxicities anti-H1N1 activities

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Antimicrobial Compounds from mangrove plants:A Pharmaceutical Prospective

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Chinese Journal of Integrative Medicine 2014年第4期20卷 311-320页

作者： Jayanta Kumar Patra Yugal Kishore Mohanta Department of Biotechnology North Orissa University Department of Biotechnology & Medical Engineering National Institute of Technology Department of Life Science National Institute of Technology

mangroves are salt-tolerant forest ecosystem that extends between tropical and subtropicalintertidal regions of the world. mangroves are biochemically unique vegetation that produce wide array of naturalproducts with immense medicinal potential. These plants are the most valuable resources and provide economicand ecological benefits to the coastal people. Natural products from these plants are of great interest as theyprovide innumerable direct and indirect benefits to human beings for the discovery of novel antimicrobial andother bioactive compounds. They possess active metabolites with some novel chemical structures that belong todiverse chemical classes such as alkaloids, phenol, steroids, terpenoids and tannins. Several mangrove specieshave been used in traditional medicine or have few applications as insecticide and pesticide. To date, severalmangroves, and their associated species and solvent extracts are screened for antimicrobial activity along withthe presence of potent bioactive compounds. The present article emphasizes and creates awareness aboutthe potential mangrove plants and their associates as a source of biologically active compounds with potentantimicrobial properties. This paper also elaborates the mechanisms of action and various methods for screeningof antimicrobial compounds.

关键词： mangrove plant antimicrobial activity natural product

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Scyphiphin D,a new iridoid glucoside dimer from-Scyphiphora hydrophyllacea

Scyphiphin D,a new iridoid glucoside dimer from-Scyphiphora ...

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第九届全国药用植物及植物药学术研讨会

作者： Yan-Bo Zeng,Wen-Li Mei,Hui Wang,Xiao-Na Li,and Hao-Fu Dai~* (a Key Laboratory of Tropical Crop Biotechnology,Ministry of Agriculture,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou, 571101,China b Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine,Haikou 571101,Hainan,P.R.China)

From the aerial parts of Scyphiphora hydrophyllacea Gaertn.F.A new iridoid glucoside dimer scyphiphin D(1) and a known iridoid glucoside geniposidic acid(2) were isolated.The structure of this new compound was determi... 详细信息

关键词： Scyphiphin D iridoid glucoside iridoid glucoside dimer Scyphiphora hydrophyllacea mangrove plant

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