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Design of manganese ion coated Prussian blue nanocarrier for the therapy of refractory diffuse large B-cell lymphoma based on a comprehensive analysis of ferroptosis regulators from clinical cases

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Nano Research 2023年第4期16卷 5265-5278页

作者： Yulu Yang Rui Chen Ke Li Pengfei Gao Yi Gong Weihu Yang Kaiyong Cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044China Department of Pathology Chongqing University Cancer HospitalChongqing 400030China Department of Phase I Clinical Trial Ward Chongqing University Cancer HospitalChongqing 400030China

Diffuse large B-cell lymphoma(DLBCL)is a prevalent human malignancy,and understanding its biology will help identify problems in refractory patients and customize alternative therapies for them.We found that DLBCL can be stratified into two independent subtypes with different clinical characteristics and outcomes by consensus clustering of expression of ferroptosis regulatory genes,which proves that ferroptosis is effective in treating refractory cases.In this work,we constructed a novel ferroptosis nanocarrier(PBPMn@PEG)by coating Prussian blue nanoparticles with manganese ions and encapsulating them with poly(ethyleneglycol).The low efficiency of the Fenton reaction of Prussian blue nanoparticles can be improved greatly by manganese coating,and can effectively generate hydroxyl radicals,and induce ferroptosis of lymphoma cells(SU-DHL-10 cells)by down-regulating ferroptosis suppressor genes and up-regulating ferroptosis driver genes.It also induces effective cell apoptosis,which is synergistic with ferroptosis for DLBCL therapy.In vivo experiments also prove that PBPMn@PEG achieved a better anti-tumor effect by up-regulating COX2,HO-1/hemeoxygenase-1(HMOX1),and NADPH oxidase-4(NOX4),and downregulating FSP1 and GPX4,with lower biotoxicity.As a novel and potential DLBCL drug carrier,our discovery served as a foundation for the treatment of the refractory DLBCL by inducing ferroptosis for DLBCL treatment in addition to the therapeutic effect of drugs.

关键词： diffuse large B-cell lymphoma(DLBCL) ferroptosis Prussian blue nanoparticles manganese ion tumor therapy

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THERMODYNAMICS ADSORPTion OF manganese ion ON 1-(2-PYRIDYLAZO)-2-NAPHTHOL-6-SULPHONIC ACID IMPREGNATED RESIN

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Chinese Journal of Reactive Polymers 2008年第Z1期 104-108页

作者： TANG Shuhe WANG Jingping CHEN Jian Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers College, The Institute of Application Chemistry and Environmental Engineering, Yancheng 224002, China

An ion-exchange resin of type 201×7 was impregnated with the reagent 1-(2-Pyridylazo)-2-naphthol-6-sulphonic Acid (PAN-S). The adsorption characteristics of PAN-S resin for manganese ion were studied on the static equilibrium adsorption. Within temperature range of 288K~313K and the concentration range investigated, equilibrium data for the adsorption of manganese ions from aqueous solutions by PAN-S resin were obtained and correlated with Freundlich and Langmuir equation. The results showed that the process of the adsorption of manganese ions from aqueous solution by PAN-S was an exothermic process. Estimations of the isothermic enthalpy change of adsorption,free energy change and entropy of adsorption are reported,and the adsorption behaviors are reasonably interpreted.

关键词： PAN-S resin manganese ion Thermodynamics adsorption.

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Effects of ferrous and manganese ions on anammox process in sequencing batch biofilm reactors

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Journal of Environmental Sciences 2014年第5期26卷 1034-1039页

作者： Xiaoli Huang Dawen Gao Sha Peng Yu Tao State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology School of Forestry Northeast Forestry University

Ferrous and manganese ions, as essential elements, significantly affect the synthesis of Haem-C, which participates in the energy metabolism and proliferation of anammox bacteria. In this study, two identical sequencing batch biofilm reactors were used to investigate the effects of ferrous and manganese ions on nitrogen removal efficiency and the potential of metal ions serving as electron donor/acceptors in the anammox process. Fluorescence in situ hybridization analysis was applied to investigate the microbial growth. Results showed that the nitrogen removal increased at high concentrations of Fe2＋ and Mn2＋ and the maximum removal efficiency was nearly 95% at Fe2＋ 0.08 mmol/L and Mn2＋ 0.05 mmol/L, which is nearly 15% and 8% higher than at the lowest Fe2＋ and Mn2＋ concentrations （0.04 and 0.0125 mmol/L）. The stabilities of the anammox reactor and the anammox bacterial growth were also enhanced with the elevated Fe2＋ and Mn2＋ concentrations. The Fe2＋ and Mn2＋were consumed by anammox bacteria along with the removal of ammonia and nitrite. Stoichiometry analysis showed Fe2＋ could serve as an electron donor for NO3-N in the anammox process. Nitrate could be reduced with Fe2＋ serving as the electron donor in the anammox system, which causes the value of NO^-N/NH4-N to decrease with the increasing of N-removal efficiency.

关键词： anaerobic ammonium oxidation （anammox） ferrous ion manganese ion nitrogen removal electron donor

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