检索结果-南通市图书馆

Immune Regulation of Interleukin-27 in malignant pleural effusion

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第14期128卷 1932-1941页

作者： Shi Li Wen-Jie You Jian-Chu Zhang Qiong Zhou Huan-Zhong Shi Department of Respiratory and Critical Care Medicine Key Laboratory of Pulmonary Diseases of Health Ministry Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

Background： lnterlcukin （IL）-27 has been reported to have anti-proliferate and anti-angiogenic activities on cancer cells. However, the involvement of IL-27 in malignant pleural effusion （MPE） remains unknown. Thus, in this research, we compared the immune functions of IL-27, interferon （IFN）-γ, and IL-17 on lung cancer cells and revealed the regulatory mechanism of IL-27 in MPE. Methods： The distribution ofl L-27 in both MPE and blood was evaluated by enzyme-linked immunosorbent assay and flow cytometry. The expressions otcytokine receptors and the levels of the phosphorylated signal transducer and activator of transcription （STAT） signalings were detected by flow cytometry. As well as the effects of proliferation, apoptosis, migration, and adherent activity of IL-27, IFN-γ, and IL-17 on lung cancer cells were also explored. Results： The expression of IL-27 was increased in M PE when compared with blood （ 147.3 ± 25. 1 pg/ml vs. 100.3 ± 13.9 pg/ml, P = 0.04）. IL-27 was noted to suppress both proliferation （18.33 ±0.21 vs. 27.77 ±0.88, P = 0.0005） and migration （1.82 ±0.44 vs. 3.13 ±0.07, P = 0.04） of A549 cells, but obviously prornoted apoptosis of A549 cells （9.47 ±1.14 vs. 4.96 ±0.17, P = 0.02） by activating STAT1 signaling. Interestingly, IL-27 played totally opposite effects on A549 cells by activating STAT3 pathway. Moreover, IL-27 exerted different intercellular adherent activities ofA549 cells to pleural mesothelial cell monolayer by activating different STAT signalings. Conelusions： IL-27 might exert an important immune regulation on lung cancer cells in human pleural malignant environment.

关键词： Interleukin-27 Lung Cancer malignant pleural effusion Signal Transduction

Th17/Treg Imbalance in malignant pleural effusion

在线全文

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第1期33卷 27-32页

作者：杨卫兵叶志坚向菲张建初周琼 Department of Respiratory Diseases Key Laboratory of Pulmonary Diseases of Health MinistryUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology

Both T helper IL-17-producing cells （Thl7 cells） and regulatory T cells （Tregs） have been found to be increased in malignant pleural effusion （MPE）. However, the possible imbalance between Thl7 cells and Tregs, as well as the association ***7/Treg and Thl/Th2 cells in MPE remains to be elucidated. The objective of the present study was to investigate the distribution of Th 17 cells in relation to Tregs, as well as Thl/Th2 balance in MPE. The number ofThl7, Tregs, Thl, and Th2 cells in MPE and peripheral blood was determined by using flow cytometry. The relationship among the number of Thl7, Tregs, Thl, and Th2 cells was explored. It was found that the number of Thl7, Tregs, Thl, and Th2 cells was all increased in MPE as compared with the corresponding peripheral blood. The number of Thl7 cells was correlated negatively with Tregs in MPE, but not in blood. Thl7 cells and Thl7/Treg ratio were positively, and Tregs were negatively, correlated with Thl cells, but not with either Th2 cells or Th1/Th2 ratio in MPE. This study supports earlier data that both Thl7 cells and Treg are present at higher frequencies in MPE than in the autologous blood. For the first time, we show that Thl7/Treg imbalance exists in MPE.

关键词： malignant pleural effusion regulatory T cells Thl7 cells Thl/Th2 imbalance

Clinical Observation on the Efficacy of Xiaoshui Decoction (消水方) Combined with Intrapleural Perfusion of Cisplatin in Treating malignant pleural effusion

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2008年第4期14卷 257-261页

作者：施展何庆勇花宝金 Guang'anmen Hospital China Academy of Chinese Medical Sciences

Objective： To observe the clinical efficacy of Xiaoshui decoction （XSD,消水方） combined with intrapleural perfusion of cisplatin in the treatment of malignant pleural effusion. Methods： Fifty-one patients with malignant pleural effusion were randomly assigned to two groups. The treated group patients） received oral administration of XSD combined with intrapleural perfusion of cisplatin, and control group （25 patients） was only treated with intrapleural perfusion of cisplatin. The effects of 26 he he short-term efficacy, quality of life scores and clinical symptom scores of malignant pleural effusion were evaluated. Results： The short-term efficacy in the treated group and the control group was 72.0% and 58.3%, respectively, and no significant difference was found （P〉0.05）. In contrast, the quality of life in the treated group was significantly improved compared to that of the control group （P〈0.05）, and so was the symptom remission （P〈0.05）. Conclusions： The combined therapy of XSD and intrapleural perfusion of cisplatin did not show obvious improvement in short-term efficacy, but the therapy remarkably alleviated the symptoms and improved the quality of life of patients.

关键词： Xiaoshui decoction malignant pleural effusion cisplatin clinical efficacy

Clinical Value of Vascular Endothelial Growth Factor Combined with Interferon-γ in Diagnosing malignant pleural effusion and Tuberculous pleural effusion

在线全文

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第5期27卷 495-497页

作者：薛克营熊盛道熊维宁 Department of Respiratory Disease Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

In order to investigate the clinical value of vascular endothelial growth factor （VEGF） combined with interferon-γ （IFN-γ） in diagnosing malignant pleural effusion and tuberculous pleural effusion, 42 cases of malignant pleural effusion and 45 cases of tuberculous pleural effusion in Tongji Hospital, from March 2004 to May 2005, were included, The carcinoembryonic antigen （CEA）, VEGF and IFN-γ levels of pleural effusion were detected by using ELISA, and adenosine deaminase （ADA） activity was determined by using enzyme kinetic analytical method. The sensitivity, specificity, accuracy and area under the curve （AUCR^ROC） of CEA and VEGF, VEGF/IFN-γ ratio, ADA and IFN-γ were measured by receiver operating characteristic curve （ROC）, The results showed that CEA, VEGF levels and VEGF/IFN-γ ratio were significantly higher and the ADA and IFN-γ levels were significantly lower in malignant group than those in tuberculous group （P〈0,01）, The sensitivity, specificity, accuracy and AUCR^ROC of VEGF/IFN-γ ratio （88,7%, 99,8%, 94,4%, 0.96 respectively） were higher than those of CEA （67.8%, 96.1%, 82,4%, 0.78 respectively） and VEGF （81,5%, 84,3%, 82.9%, 0.79 respectively）. The sensitivity, specificity, accuracy and AUCR^ROC of IFN-γ （85.7%, 96,4%, 90.9%, 0.94 respectively） were higher than those of ADA （80,2%, 87,6%, 83.8%, 0,81 respectively）. It was concluded that VEGF/IFN-γ ratio and IFN-γ could be used as valuable parameters for the differential diagnosis of malignant pleural effusion and tuberculous pleural effusion.

关键词： vascular endothelial growth factor interferon-γ malignant pleural effusion tuberculous pleural effusion

Meta Analysis of Lentinan Injection plus Cisplatin in Treatment of malignant pleural effusion

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2011年第4期3卷 310-318页

作者： WANG Quan HE Xi-ran WANG Man-cai TIAN Jin-hui Evidence Based Medicine Center of Lanzhou University Lanzhou 730000China The First Clinical Medical College of Lanzhou University Lanzhou 730000China

Objective To evaluate the efficacy and safety of lentinan injection plus cisplatin(LIC)in the treatment of malignant pleural effusion(MPE).Methods We searched the database of Cochrane Library,PubMed,EMBASE, ISI Web of Knowledge,Chinese Biomedical Literature Database,Chinese Scientific Journals Full-text Database, Chinese Journal Full-text,and Google Scholar,etc.,up to February 28th,2011 to identify randomized controlled trials(RCTs)about lentinan injection(LI)for MPE,evaluate the quality of the included studies,and analyze the data by Cochrane Collaboration’s RevMan5.0 *** Twenty-nine RCTs involving 1831 patients were *** analysis results suggested that there were some differences when comparing LIC with control groups suffering from MPE,for LIC could improve the near-term curative effect and the quality of life to some extent. Besides,compared with chemotherapy alone,LI plus chemotherapy had an advantage in relieving adverse reactions, such as gastrointestinal reactions,myelosuppression,chest pain,and general *** The current evidence indicates that LI may have adjuvant therapeutic effects for MPE.

关键词： chemotheraphy cisplatin lentinan injection malignant pleural effusion meta analysis

Study on the Correlation between Syndrome Differentiation of malignant pleural effusion Treated by External Treatment of Traditional Chinese Medicine and Immunohistochemistry of Biopsy Tissue Based on Medical Video-assisted Thoracoscope

在线全文

学校读者我要写书评

暂无评论

Cancer Advances 2021年第6期4卷 19-22页

作者： De-Min Li Xin-Yang Shu Dao-Wen Yang Bing-Lin Zhang Zhen Wang Department of Pulmonary Diseases of Traditional Chinese Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijingChinaNational Center for Respiratory MedicineBeijingChinaInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijingChinaBeijing 100029 National Clinical Research Center for Respiratory DiseasesBeijingChina Department of Pathology China-Japan Friendship HospitalBeijing 100029China Beijing Institute of Respiratory Diseases Department of Respiratory and Critical Care MedicineBeijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100020China.

Objective:Guided by the theory of syndrome differentiation of yin and yang in traditional Chinese medicine surgery,through visual observation of internal medicine thoracoscope,comprehensive observation of pleural cavity and immunohistochemistry of biopsy tissue,to classify malignant pleural effusion according to syndrome differentiation,and to explore the scientific nature of its ***:From March 1,2014 to February 28,2015,40 cases of malignant pleural effusion were treated in Beijing Chaoyang Hospital affiliated to Capital Medical *** to the proposed TCM diagnostic criteria for yin and yang syndrome differentiation,and collect age,gender,course of disease,clinical symptoms,tumor primary focus,histomorphological manifestations and immunohistochemical results and other related information,and carry out statistical data ***:The positive syndrome was mainly metastatic lung adenocarcinoma,which accounted for the majority of all MPE cases,up to 75%.The immunohistochemical results of biopsy tissues were mainly CEA and TTF-1 positive;While pleural effusion caused by pleural mesothelioma was the main type of yin syndrome,and the results of immunohistochemistry combined with biopsy were mainly positive for D2-40,Calretinin,WT-1 and CK5/***:TCM syndrome differentiation of MPE based on internal thoracoscopy combined with biopsy immunohistochemical results has sufficient theoretical basis and certain scientific nature,and further clinical research is needed to verify its effectiveness and practicability in the future.

关键词： malignant pleural effusion medical thoracoscope external treatment of traditional Chinese medicine syndrome differentiation immunohistochemistry

The Observation of Clinical Efficacy and Safety of De-Platinum-Based pleural Perfusion in the Treatment of malignant pleural effusion and Its Correlation with the Expression of VEGF in pleural Fluid

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2024年第12期15卷 432-445页

作者： Peng Wang Chufeng Zhang Pengpeng Hao Shuyan Wang Rongguang Zhu Juanjuan Li Yiming Bi Ward Two of Department of Oncology Binzhou Peoples Hospital Binzhou China Ward One of Department of Respiratory Oncology Cancer Hospital Affiliated to Shandong First Medical University (Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences) Jinan China Ward Four of Department of Oncology Binzhou Central Hospital Binzhou China Radiology Department Binzhou Peoples Hospital Binzhou China

Background: malignant pleural effusion (MPE) is the most common complication of advanced NSCLC. Infusion chemotherapy is currently one of the most common intracavitary treatments for MPE. Unfortunately, there is no definitive consensus on which intracavitary infusion drug has the best effect on the treatment. The use of de-platinum-based thoracic perfusion therapy can offer several advantages, such as reducing drug toxicity and contributing to an improvement in patients’ physical condition. Therefore, this study was to investigate the clinical efficacy and safety of de-platinum-based pleural perfusion bevacizumab combined with Brucea Javanica Oil Emulsion Injection (BJOEI) in the treatment of malignant pleural effusion in advanced lung adenocarcinoma. Methods: A total of 60 patients diagnosed with lung adenocarcinoma and malignant pleural effusion were selected from Binzhou People’s Hospital, Shandong Provincial Cancer Hospital, and Binzhou Central Hospital between June 2022 and May 2024, with 30 cases treated in each group. The study was divided into two groups: the treatment group received bevacizumab injection perfusion in combination with intravenous infusion of Brucea Javanica Oil Emulsion Injection (BJOEI), while the control group received bevacizumab injection combined with cisplatin perfusion. To analyze the data and evaluate their efficacy and adverse reactions, such as disease control rate (DCR), overall response rate (ORR), Karnofsky Performance Status (KPS), vascular endothelial growth factor (VEGF), and so forth. Results: Following the treatment, the quality of life scores in both groups exhibited an increase compared to pre-treatment levels. Moreover, the enhancement observed in the treatment group was deemed statistically significant (P = 0.007). Following treatment, The expression of VEGF in the pleural effusion of both groups of patients was significantly decreased, and the disparity within the same group was found to be statistically significant (P

关键词： Bevacizumab Brucea Javanica Oil Emulsion Injection Advanced Lung Adenocarcinoma malignant pleural effusion

Expression of Interleukin21and CEA in Tuberculous and malignant pleural effusion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression of Interleukin21and CEA in Tuberculous and Malign...

作者： Hansvin Bunjhoo 华中科技大学

学位级别：硕士

The aim of this study was to evaluate the diagnostic value of Interleukin21（IL-21）andcarcinoembryonic antigen （CEA） in tuberculous pleural effusions （TPEs）and malignant pleural effusions （MPEs）. pleural effusion samples from50patientswere classified on the basis of diagnosis as TPE （n=21） and MPE （n=29）. Theconcentration of IL-21was determined by ELISA. Lactate dehydrogenase （LDH）,adenosine dehydrogenase （ADA） and CEA levels were also determined in allpatients. A significant difference was observed in the levels of ADA and CEA（P＜0.01）, but not in the levels of LDH （P＞0.05） between TPE and MPE. Theconcentration of IL-21in MPE was significantly higher compared to TPE（P＜0.01）. With a threshold value of4.32pg/ml, IL-21had a sensitivity of96.6%（28/29）, a specificity of95.20%（20/21）, an accuracy of96.0%（48/50）. Thecombined detection of IL-21and CEA had a sensitivity of100%（29/29） and aspecificity of96.43%（27/28） to distinguish TPE from MPE. MPEs showedsignificantly higher levels of IL-21compared to TPEs.

关键词： Interleukin 21 tuberculous malignant pleural effusion

Soluble CD40 in plasma and malignant pleural effusion with non-small cell lung cancer:A potential marker of prognosis

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Chronic Diseases and Translational Medicine 2015年第1期1卷 -页

作者： Chuan-Yong Mu Pang-Xue Qin Qiu-Xia Qu Cheng Chen Jian-An Huang Respiratory Department The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Gastrointestinal Department The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Biotechnology Research Institute Soochow University 48 Renmin Road Suzhou Jiangsu 215007 China

Objective: Soluble CD40 (sCD40) is a potential modulator for both antitumor responses and CD40-based immunotherapy;however the levels and significance of sCD40 in non-small cell lung cancer (NSCLC) patients with malignant pleural effusion are unknown. Methods: Forty-eight patients with lung cancer were treated in our institutions from January 2008 to January 2010. Peripheral blood and pleural effusion samples were collected from each subject. sCD40 levels in plasma and malignant pleural effusions supernatant were measured. The CD40L expression on CD3t T-cells was confirmed by flow cytometric direct immunofluorescence analysis. All patients were followed up after the study ended on January 1, 2010. Results: Patients with malignant pleural effusion of NSCLC had elevated circulating and pleural effusion levels of sCD40, and these elevated sCD40 levels were associated with advanced diseases and a poor prognosis. Conclusions: These findings indicate that elevated sCD40 may have a role in modulating antitumor responses and may also be a useful prognostic marker. Copyright ? 2015, Chinese Medical Association Production. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Soluble CD40 malignant pleural effusion Prognosis

同方期刊数据库