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Epidemiology and trend analysis on malignant mesothelioma in China

Chinese Journal of Cancer Research 2017年第4期29卷 361-368页

作者： Jun Zhao Tingting Zuo Rongshou Zheng Siwei Zhang Hongmei Zeng Changfa Xia Zhixun Yang Wanqing Chen National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Objective： Population-based cancer registration data were used to analyze the epidemiology and trend of malignant mesothelioma in China, and the result would provide basic data for its prevention and control. Methods： malignant mesothelioma data in 2013 were retrieved from the database of National Cancer Registry. malignant mesothelioma incidence and mortality were estimated using age-specific rate by urban/rural and gender according to the national population in 2013. malignant mesothelioma data from 22 cancer registries were used for trend analysis during 2000-2013. Results： It is estimated that there were 2,041 new malignant mesothelioma cases and 1,659 malignant mesothelioma deaths occurred in 2013. The crude incidence rate in China were 1.50/106 （males 1.67/106, females 1.32/106）, age-standardized incidence rates by Chinese standard population （ASIRC） and by world standard population （ASIRW） were 1.03/106 and 1.02/106, respectively. The crude mortality rate in China was 1.22/106 （males 1.67/106, females 1.32/106）, age-standardized mortality rates by Chinese standard population （ASMRC） and by world standard population （ASMRW） were 0.83/106 and 0.81/106, respectively. There was an increasing trend of incidence rate for malignant mesothelioma in registration areas of China during 2000-2013 with annual percentage change （APC） of 2.5% [95% confidence interval （95% CI）： 0.6%--4.5%]. After age standardization, no significant differences were observed. No matter for crude mortality rates or age-standardized mortality rates, no significant differences were observed during 2000-2013. Conclusions： malignant mesothelioma is the major occupational and environmental neoplasm associated with asbestos exposure. The increasing incidence trend suggests that more attention should be paid on this disease.

关键词： malignant mesothelioma incidence mortality trend cancer registry

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Reactive oxygen species in the progression and treatment of malignant mesothelioma

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 210-220页

作者： Ava Cote Terri Messier Brian Cunniff Department of Pathology and Laboratory Medicine Redox Biology ProgramUniversity of Vermont Larner College of MedicineBurlingtonVT 05405USA University of Vermont Cancer Center University of Vermont Larner College of MedicineBurlingtonVT 05405USA

malignant mesothelioma(MM)is an aggressive cancer that affects the pleural and peritoneal mesothelial lining of the lungs and *** rates for patients with MM remain extremely low and effective treatments are *** tumors harbor both genotypic and phenotypic features that indicate MM tumor cells are under increased oxidative stress,similar to other aggressive *** increased oxidative stress in MM cells supports aggressive growth while providing a therapeutic vulnerability exploitable by redox-modulating *** tumor cells also exhibit altered mitochondrial structure and function that contribute to the disease through perturbations in metabolism and reactive oxygen species(ROS)production and *** the altered redox status in cancer through increasing cellular ROS levels directly or inhibiting cellular antioxidant pathways and disrupting ROS scavenging mechanisms has become an exciting area for therapeutic *** review discusses ROS sources and signaling,mitochondrial structure and function and targeting mitochondria ROS as a therapeutic approach for the treatment of MM.

关键词： malignant mesothelioma targeting cellular redox status pro-oxidant therapy

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Burden of malignant mesothelioma in China during 1990-2019 and the projections through 2029

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Journal of the National Cancer Center 2024年第3期4卷 214-222页

作者： Qiulin Huang Youli Chen Liyou Lian Qiqi Lei Jinfei Chen Licun Wu Kari Hemminki Jianguang Ji Tianhui Chen Department of Cancer Prevention Zhejiang Cancer HospitalHangzhouChina Hangzhou Institute of Medicine(HIM) Chinese Academy of SciencesHangzhouChina School of Public Health Hangzhou Normal UniversityHangzhouChina State Key Laboratory for Oncogenes and Related Genes NHC Key Laboratory of Digestive Diseases Division of Gastroenterology and HepatologyShanghai Institute of Digestive DiseaseRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina The First Affiliated Hospital of Wenzhou Medical University WenzhouChina 6 Latner Thoracic Surgery Research LaboratoriesDivision of Thoracic SurgeryToronto General HospitalPrincess Margaret Cancer Research CentreUniversity Health NetworkUniversity of TorontoTorontoCanada Biomedical Center Faculty of Medicine and Biomedical Center in PilsenCharles University in PraguePilsenCzech Republic Division of Cancer Epidemiology German Cancer Research CenterHeidelbergGermany Department of Gynecology Oncology Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFujianChina Center for Primary Health Care Research Lund UniversityMalmöSweden

Objective:To provide the most up-to-date data on the burden of malignant mesothelioma(MM)and the projections through 2029 in ***:Data on patients diagnosed with MM from China during 1990-2019 were obtained from the Global Burden of Disease(GBD)2019 database,including annual cases and deaths data and age-standardized rates of incidence,mortality,and disability-adjusted life-years(DALYs)associated with MM among different age *** trends during 1990-2019 were analyzed by the Joinpoint regression models using 95%confidence interval(CI),while the projections through 2029 were calculated by the Bayesian age-period-cohort *** on the production and consumption of asbestos in China were obtained from the United States Geological Survey on Mineral Commodity Summaries during ***:We observed a significant elevation in incident new cases and deaths over the last 3 decades,increasing from 1193 in 1990 to 2815 in 2019 for incident cases and from 1134 in 1990 to 2773 in 2019 for death *** found a roughly 6%increase in the proportion of incident cases for those aged>70 years(30%in 2019 versus 24%in 1990),while for the proportion of deaths similar elevation for those aged>70 years was ***,men had significantly higher DALYs due to MM across age groups compared with *** consumption in China dramatically dropped since 2012 and reached the bottom in 2017 with 230 *** 2029,the projected age-standardized rate for incidence and mortality is expected to reach 1.2 per million for ***:We found,for the first time using GBD data on the Chinese population,that the burden of MM has been significantly increasing in China over the last three decades and will continue to increase in the upcoming decade,suggesting an urgent need for a complete ban on chrysotile asbestos in China.

关键词： malignant mesothelioma Cancer burden China Global Burden of Disease(GBD)2019

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HMGB1 as a Potential Biomarker for malignant mesothelioma

HMGB1 as a Potential Biomarker for Malignant Mesothelioma

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华东六省一市生物化学与分子生物学会联盟2019年学术与教学交流会

作者： Yanbin Wang Shibo Ying Institute of Occupational Diseases Zhejiang Academy of Medical Sciences

malignant mesothelioma(MM) is a rare,aggressive and highly lethal cancer that is substantially induced by exposure to asbestos ***-mobility group box1(HMGB1) is an intriguing proinflammatory molecule involved in *** this study,we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on in vivo and in vitro experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for *** conclude that novel strategies targeting HMGB1 may suppress MM cells and interfere with asbestos-induced inflammation.

关键词： HMGB1 malignant mesothelioma Biomarker Asbestos

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Immunophenotypings of malignant Epithelial mesothelioma and Their Roles in the Differential Diagnosis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第2期24卷 112-115页

作者：阮秋蓉胡余昌 Department of Pathology School of Basic Medical Sciences Tongji Medical College Huazhong University of Science and Technology

To investigate the immunophenotypings of malignant epithelial mesothelioma (MEM), and to seek the valuable markers in distinguishing peritoneal MEM from peritoneal metastatic ovarian adenocarcinoma (OA) and colorectal adenocarcinoma (CA), immunohistochemical SP method was used to detect expressions of HBME-1, E-cadherin, CA19-9, MOC-31 and CK7 in paraffin-embedded tissues of 18 cases of MEM, 20 OA and 20 CA. The results showed that there was a significant difference in the expressions of E-cadherin, CA19-9 and MOC-31 between MEM and OA group (P<0.05). Similarly, the difference in the expression of HBME-1, E-cadherin, CA19-9, MOC-31 and CK7 between MEM and CA groups is significant (P<0.05). These results indicate that HBME-1 could be used as a positive marker in distinguishing MEM from CA. E-cadherin, CA19-9 and MOC-31 are considered to be useful negative markers in diagnostic distinction between MEM and metastatic adenocarcinomas, including OA and CA. CK7 is the best positive marker in distinguishing MEM from CA, but this marker appears to be valueless in discriminating MEM from OA.

关键词： malignant mesothelioma metastatic adenocarcinoma immunophenotyping HBME-1 E-cadherin CA19-9 MOC-31 CK7

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Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

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World Journal of Gastroenterology 2009年第5期15卷 615-621页

作者： Motoko Sasaki Ichiro Araki Toshiaki Yasui Masaru Kinoshita Keita Itatsu Takayuki Nojima Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Kanazawa 920-8640 Japan Department of Internal Medicine Asanogawa General Hospital Kanazawa 920-8621 Japan Department of Surgery Asanogawa General Hospital Kanazawa 920-8621 Japan Hanazono Medical Office Kanazawa 920-0293 Japan Department of Pathology Kanazawa Medical University Ishikawa 920-0293 Japan

We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type.

关键词： malignant mesothelioma Pulmonaryasbestosis Liver Immunohistochemistry

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THE CLINICOPATHOLOGICAL AND PROGNOSTIC STUDY ON 42 CASES WITH CARDIAC TUMOR

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Chinese Journal of Cancer Research 1996年第2期8卷 135-139页

作者：王绪洲梁思泰王敏李素英 Department of Pathology The Affiliated Hospital Shandong Medical University Jinan Western Hospital of Jinan Railroad Bureau Jinan

: Objective: To analyze the relation between the pathological changes and the clinical manifestations and the prognosis of cardiac tumors through the pathological study on 42 cases with cardiac tumor, in order to improve the knowledge of the tumors, to make early diagnosis and to raise the curative *** and Methods: 42 confirmed cardiac tumors of our department were selected, among whick 41was surgical specimen and 1 was autopsy. The study was Pcrformed by using the common and special histochemical ***: 41 is Primary and 1 is secondary which is a metastazed hepatocelular carcinoma. In the Primary ones,39 (95.1%) is benign, including myxoma, fibroma,rhabdomyoma and Pericardial cyst, while 2 (4. 9%) is malignant, including neuroleminafibrosarcoma and malignant mesothelioma. In the myxomas, female patients occupy 75%, 91.7% exists in the left atrium and every one has got a peduncle adbesive to the fossa ovalis or adjacency of the atrial ***: The results of the pathological and prognostic study sbowes cardiac tuinors are quite different from the tumors in other sites, i.e., cven benign ones could cause fatal hemodynamic disturbance. Hence early diagnosis and early operation are necessary and if in such instance, the Prognosis of inost of the benign oncs would be good. But the prognosis of the malignant tumors is worst. The myxomas are different from the organized thrombi in heart cavity. And also the criteria of diagnosis and differential diagnosis are discussed.

关键词： Cardiac tumor Myxoma Fibroma,Rhabdomyoma Neurolemmafibrosarcoma malignant mesothelioma Patbology

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腹膜恶性间皮瘤的临床回顾性分析

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中华消化病与影像杂志（电子版） 2013年第6期3卷 310-312页

作者：魏思忱郑国启杨雨鑫宋慧梁育飞魏新亮张秀刚河北省沧州市中心医院消化内科 061001

腹膜恶性间皮瘤(peritoneal malignant mesothelioma,PMM)是唯一原发于腹腔浆膜间皮和间皮下层细胞的恶性肿瘤,是一种罕见病,一般人群发病率为百万分之一至二,且恶性程度高,预后极差[1].近年来其发病率有增加趋势,沧州市中心医院5年间... 详细信息

腹膜恶性间皮瘤(peritoneal malignant mesothelioma,PMM)是唯一原发于腹腔浆膜间皮和间皮下层细胞的恶性肿瘤,是一种罕见病,一般人群发病率为百万分之一至二,且恶性程度高,预后极差[1].近年来其发病率有增加趋势,沧州市中心医院5年间共确诊腹膜间皮瘤患者138例,且大多数与石棉接触有关,本研究旨在探讨该地区腹膜间皮瘤的发病与接触石棉的关系、流行病学及其临床特点.

关键词：腹膜恶性间皮瘤 malignant mesothelioma 腹膜间皮瘤发病率中心医院一般人群石棉接触流行病学临床特点恶性肿瘤恶性程度罕见病沧州市细胞皮下浆膜极差患者腹腔地区

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