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Successful endoscopic hemostasis for gastric arterial bleeding due to invasion of malignant lymphoma

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World Journal of Gastroenterology 2005年第27期11卷 4285-4286页

作者： Kenichi Nomura Shinya Yamada Daisuke Shimizu Takashi Okuda Yuri Kamitsuji Naohisa Yoshida Yosuke Matsumoto Naoki Wakabayashi Kazuya Mikami Shigeo Horiike Takeshi Okanoue Masafumi Taniwaki Masafumi Taniwaki Molecular Gastroenterology and Hepatology Department of Urology Clinical Molecular Genetics and Laboratory Medicine

A 75-year-old male with malignant lymphoma (ML) accompanied with gastric lesion was treated with combination chemotherapy. The patient produced tarry stool on the 4th d, and emergency gastroscopy showed arterial bleeding from the lesion. Hemostasis was achieved by injecting pure ethanol and using hemostatic clips. There is only one previous report on endoscopic hemostasis being effective for bleeding due to lymphoma. Since gastric bleeding causes significant mortality, endoscopic hemostasis should be considered as first-line treatment for ML patients who were treated with chemotherapy.

关键词： malignant lymphoma Endoscopic hemostasis Pure ethanol injection Hemostatic clips

Relevance on the diagnosis of malignant lymphoma of the salivary gland

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World Journal of Clinical Cases 2020年第13期8卷 2717-2726页

作者： Xin-Yue Zhang Zhi-Ming Wang Department of Stomatology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

malignant lymphoma originates from the lymphohematopoietic *** can occur in any lymphoid *** lymphoma of the salivary gland is rare,but its incidence has increased in recent *** clinical-presentations are nonspecific,and it is often manifested as a painless mass in a salivary gland,which can be accompanied by multiple swollen cervical lymph *** of the diagnosis before an invasive procedure is ***,malignant lymphoma of the salivary gland tends to be misdiagnosed,leading to an inappropriate treatment plan and the ultimate delay in the optimal treatment of the *** article reviews the pathogenesis,clinical features,imaging findings,diagnosis,treatment and prognosis of malignant lymphoma of the salivary gland.

关键词： Salivary gland malignant lymphoma Pathogenic factors Clinical features Diagnosis Treatment

Clinical Analysis of 10 AIDS Patients with malignant lymphoma

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Clinical oncology and cancer researeh 2012年第2期9卷 115-119页

作者： Gui-ju Gao Di Yang Ke-ke Lin Jiang Xiao Xin Li Hong-yuan Liang Long Liu Ning Han Hong-xin Zhao Beijing Ditan Hospital Capital Medical University School of Nursing Peking University

Objective This work summarizes the clinical features and treatment of 10 AIDS patients with malignant lymphoma. Methods A total of 10 AIDS patients with malignant lymphoma seen in Beijing Ditan Hospital since 2009 were enrolled. Clinical manifestations, pathological examinations, immunity levels, Epstein-Barr virus antibody examinations, complications, treatments, and outcomes were retrospectively analyzed. Results The main clinical manifestations of these patients included intermittent fever in 2 cases, neck masses and fever in 3 cases, auxiliary lymph node enlargement in 2 cases, and abdominal pain and bloating with fever in 3 cases. Up to 7 patients were pathologically diagnosed with diffuse large B cell lymphoma （DLBCL）, and 3 patients were pathologically diagnosed with Burkitt＇s lymphoma. Up to 8 patients had CD4 cell counts below 200/μL, and 2 patients had a level of more than 200/μL. Up to 7 patients were negative for EBV-IgM antibodies and 3 patients were not examined. Six patients underwent different chemotherapy and their prognoses were different. One patient with Burkitt＇s lymphoma alternatively took CODOXM and IVAC for 3 turns after VP chemotherapy; 1 patient with liver metastasis took R-CHOP 5 times, then changed therapy regimen to R-MINE and MINE. One patient with adrenal DLBCL took CHOP 6 times. Three patients with DLBCL took CHOP 1 or 2 times. Four patients gave up treatment. Various infections and side effects occurred, including bone marrow suppression, gastrointestinal bleeding, and renal dysfunction during chemotherapy. Six patients took HAARI, and 4 did not. Six patients died, whereas 3 patients got improved; and 1 patient was discharged. Conclusions AIDS patients with malignant lymphoma had various clinical manifestations, were immunocompromised, and had multiple metastases when they were admitted; they were already in the interim or late stage of lymphoma. Chemotherapy was not effective, and additional complications occurred. HAART failed to i

关键词： acquired immunodeficiency syndrome (AIDS) malignant lymphoma chemotherapy HAART. prognosis

COMBINATION CHEMOTHERAPY WITH COBDP IN malignant lymphoma: AN ANALYSIS OF 64 CASES

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Chinese Journal of Cancer Research 1991年第3期3卷 60-66页

作者：金杏泉许越香赵体平

From February 1986 to February 1989, 64 patients with malignant lymphoma were treated with COBDP regimen. Of these patients, there were 7 cases with Hodgkin's disease and 57 cases with non Hodgkin's lymphoma. Clinical staging showed 7 stage Ⅰ , 5 stage Ⅱ, 22 stage Ⅲ and 30 stage Ⅳ . The COBDP regimen was carried out as : Cyclophosphamide 600 mg iv on days 1,8; vincristine 2 mg iv on days 1,8; Pingyanymycin long im on days 1, 4, 8, 11; cis-dichlorodiamineplatinum 20 mg iv drip on day 1 - 5 and prednisone 10 mg po tid on day 1 -14. Treatment results showed 39% (25 cases) achieving complete remission (CR) , 52% (33 cases) partial remission (PR) , giving an over-all response rate of 91 % (CR+PR). There was a significant difference in the CR of the untreated patients (56%) and that of the treated ones (28%) (P 12 months, vs >9 months) and the median surrivals of the CR patients (> 16. 5 months, vs > 15 months) (Plymphomas.

关键词： COBDP regimen malignant lymphoma complete remission median survival.

Clinical Analysis of 29 Cases with Primary malignant lymphoma of the Prostate

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Chinese Journal of Clinical Oncology 2007年第2期4卷 129-132页

作者： Tong Fang Beijing Shijitan Hospital Department of Radiation Oncology Beijing 100038 China

OBJECTIVE To summarize the clinical characteristics, pathology, treatment and prognosis of malignant lymphoma of the prostate. METHODS Clinical data from 29 patients with primary malignant lymphoma of the prostate were reviewed retrospectively. The median age was 66 years. Clinical signs and symptoms were due to lower urinary tract obstruction resulting from a diffusely enlarged prostate. Prostate biopsies revealed diffuse large B-cell non-Hodgkin＇s lymphoma. The therapeutic modalities included prostatectomy, radiotherapy and chemotherapy. RESULTS Extraprostatic involvement at various sites became evident in 19 of the 29 patients after diagnosis. Ten patients died from lymphoma with a median survival of 23 months （range, 2-30 months）. Seven patients were alive up to 60 months. CONCLUSION malignant lymphoma involving the prostate was rare and has a rather poor prognosis. Prognosis related to the patient age, histologic type, and treatment or clinical stage of the disease at presentation.

关键词： malignant lymphoma non-Hodgkin's prostate

OKT_（10）　POSITIVE　CELLS　IN　PERIPHERAL　BLOOD　OF　MULTIPLE　MYELOMA　AND　malignant　lymphoma

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Journal of Pharmaceutical Analysis 1995年第2期9卷 120-121页

作者：陈开浚邵文斌

patients with maligant lywioma and 18 patients with multiple myeloma were investigated for expression of OKT10 in Peripheral blood. A significant increasing of OKT10 positive cells was found in most of patients(26/3espectively) with Non_Hodgekin's lymphoma(NHL)and multiple myeloma(MM). The increasing of OKT10 positive cells is related to the degree of malignancy of patients with NHL from low_grade to high_*** is useful to judge prognosis of *** presence of OKT10 positive cells was unrelated with treatment status and clinic phases. some of OKT10 positive cells belong to neoplastic precursors.

关键词： OKT_(10) lymphocyte multiple myeloma malignant lymphoma

Value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas using automated biopsy gun

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World Journal of Gastroenterology 2005年第31期11卷 4843-4847页

作者： Li Li Qiu-Liang Wu Li-Zhi Liu Yun-Xian Mo Chuan-Miao Xie Lie Zheng Lin Chen Pei-Hong Wu State Key Laboratory of Ontology in Southern China Imaging Diagnosis and Intervenfional Center Cancer Center Sun YatoSen University Guangzhou 510060 Guangdong Province China State Key Laboratory of Oncology in Southem China Department of Pathology Cancer Center Sun YatoSen University Guangzhou 510060 Guangdong Province China

AIM: To evaluate the value of CT-guided core-needle biopsy in diagnosis and classification of malignant ***: From January 1999 to October 2004, CT-guided core-needle biopsies were performed in 80 patients with suspected malignant lymphoma. Biopsies were performed with an 18-20 G biopsy-cut (CR Bard, Inc., Covington, GA,USA) needle driven by a spring-loaded Bard biopsy ***: A definite diagnosis and accurate histological subtype were obtained in 61 patients with a success rate of 76.25% (61/80). Surgical sampling was performed in 19 patients (23.75%) with non-diagnostic core-needle biopsies. The success rate of CT-guided core-needle biopsy varied with the histopathologic subtypes in our *** relatively high success rates of core-needle biopsy were noted in diffuse large B-cell non-Hodgkin's lymphoma (NHL, 88.89%) and peripheral T-cell NHL (90%). However,the success rates were relatively low in anaplastic large cell (T/null cell) lymphoma (ALCL, 44.44%) and Hodgkin's disease (HD, 28.57%) in our ***: CT-guided core-needle biopsy is a reliable means of diagnosing and classifying malignant lymphomas,and can be widely applied in the management of patients with suspected malignant lymphoma.

关键词： malignant lymphoma Biopsy Computedtomography

Mucosa-associated lymphoid tissue lymphoma of the transverse colon: A case report

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World Journal of Gastroenterology 2006年第34期12卷 5573-5576页

作者： Shigetoshi Matsuo Yohei Mizuta Tomayoshi Hayashi Seiya Susumu Ryuji Tsutsumi Takashi Azuma Satoshi Yamaguchi Department of Surgery Nagasaki Prefectural Shimabara Hospital Shimabara Nagasaki Japan Second department of Internal medicine Nagasaki University School of Medicine Nagasaki Japan Department of Pathology Nagasaki Prefectural Shimabara Hospital Shimabara Nagasaki Japan

We herein present a case of a 75-year-old female with mucosa-associated lymphoid tissue （MALT） lymphoma of the transverse colon with the stage IE （Ann Arbor classification）. Colonoscopy revealed the tumor＇s appearance as a IIa plus Ⅱ c-like early colon cancer as defined according to the macroscopic classification of the Japanese Research Society for Cancer of Colon, Rectum and Anus, measuring less than 2 cm in diameter. Histologically, the tumor was diagnosed as MALT lymphoma because of the presence of lymphoepithelial lesions consisting of diffuse proliferation of atypical lymphocytes and glandular destruction. The majority of these lymphocytes immunohistochemically stained for the B-lymphocyte marker. The patient first underwent H pylori eradication therapy with Lansap. However, the tumor size gradually increased over the next 4 mo and the patient eventually underwent surgical resection. The operative procedure included a partial colectomy with dissection of the paracolic lymph nodes. The tumor measured 45 mm × 30 mm in diameter and histological examination showed that the lymphoma cells had infiltrated the muscle layer of the colon without nodal involvement. The patient has had no recurrence postoperatively without any chemotherapy.

关键词： Mucosa-associated lymphoid tissue malignant lymphoma

Gallbladder Burkitt's lymphoma mimicking gallbladder cancer:A case report

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World Journal of Gastroenterology 2022年第6期28卷 675-682页

作者： Kiyotaka Hosoda Akira Shimizu Koji Kubota Tsuyoshi Notake Hikaru Hayashi Koya Yasukawa Kentaro Umemura Atsushi Kamachi Takamune Goto Hidenori Tomida Shiori Yamazaki Yuri Narusawa Naoko Asano Takeshi Uehara Yuji Soejima Division of Gastroenterological Hepato-Biliary-PancreaticTransplantation and Pediatric SurgeryDepartment of SurgeryShinshu University School of MedicineMatsumoto 390-8621Japan Department of Laboratory Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

BACKGROUND malignant lymphoma is a rare form of gallbladder *** of these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas;however,Burkitt’s lymphoma of the gallbladder is extremely rare,and only two previous reports are available in the ***,we report a rare case of Burkitt’s lymphoma of the gallbladder mimicking gallbladder *** SUMMARY An 83-year-old man with no abdominal complaints was found to have a gallbladder tumor and periportal lymph node enlargement on computed tomography(CT)performed for hypertension *** laboratory data revealed slightly elevated serum levels of carcinoembryonic antigen and soluble interleukin 2 *** examinations revealed two irregular and contrastenhanced masses extending into the gallbladder lumen,but these did not infiltrate the ***,a periportal lymph node had enlarged to 30 *** on these findings,we diagnosed the patient as having gallbladder adenocarcinoma with lymph node metastasis,which was treated using bile duct resection with gallbladder bed resection and periportal lymph node ***,the patient was finally diagnosed as having Burkitt’s *** the surgical margin was pathologically negative,recurrence was noted at the hepatic radical margin and superior pancreaticoduodenal lymph nodes on positron emission tomography/CT soon after ***,he was referred to a hematologist and started receiving treatment with reduced-dose cyclophosphamide,doxorubicin,vincristine,and *** Burkitt’s lymphoma can occur in the *** can be useful in cases with findings suggestive of gallbladder malignant lymphoma.

关键词： Gallbladder malignant lymphoma Burkitt’s lymphoma Gallbladder cancer Lymphadenopathy Case report