检索结果-南通市图书馆

Clinical features and diagnosis for Chinese cases with malignant hyperthermia： a case cluster from 2005 to 2007

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第10期123卷 1241-1245页

作者： WANG Ying-lin LUO Ai-lun TAN Gang CUI Xu-lei GUO Xiang-yang Department of Anesthesiology Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Anesthesiology Peking Union Medical College Hospital Chinese Academy of Medical Science & Peking Union Medical College Beijing 100730 China Department of Anesthesiology Peking University Third Hospital Beijing 100191 China

Background malignant hyperthermia （MH）, manifesting as MH crisis during and/or after general anesthesia, is a potentially fatal disorder in response to volatile anesthetics and depolarizing muscle relaxants. Though typical features of MH episode can provide clues for clinical diagnosis, MH susceptibility is confirmed by in vitro caffeine-halothane contracture test （CHCT） in western countries. It is traditionally thought that MH has less incidence and fewer typical characteristics in Chinese population than their western counterparts because of the different genetic background. In this study, we investigated the clinical features of MH in Chinese cases and applied the clinical grading scale and CHCT for diagnosis of MH. Methods A cluster of three patients with MH, from January 2005 to December 2007, were included in the study. Common clinical presentations and the results of some lab examinations were reported in detail. The method of the clinical grading scale of diagnosis of MH was applied to estimate the qualitative likelihood of MH and predict MH susceptibility. Muscle fibers of femoral quadriceps of the patients were collected and CHCT was performed to confirm the diagnosis of MH. Results The clinical grading scales of diagnosis of the disease for these cases were all ranked grade D6, suggesting almost diagnosed ones. And the results of caffeine test were positive correspondingly, indicating that the patients should be diagnosed as MH susceptibility （MHS） according to diagnostic criteria of the North America MH group, which were already confirmed by clinical presentations and biochemical results. Conclusions These Chinese cases manifest as MH crisis. The clinical grading scale of diagnosis of MH may provide clues for clinical diagnosis. CHCT can also be used in confirming diagnosis of MH in Chinese cases though they have different genetic background from their western counterparts.

关键词： malignant hyperthermia intraoperative complications diagnosis

The current status of malignant hyperthermia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2020年第2期34卷 75-85页

作者： Lukun Yang Timothy Tautz Shulin Zhang Alla Fomina Hong Liu Department of Anesthesiology the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdong 519000China Department of Anesthesiology and Pain Medicine University of California Davis HealthSacramentoCA 95817USA Department of Pathology and Laboratory Medicine College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Physiology and Membrane Biology University of California Davis HealthSacramentoCA 95817USA

malignant hyperthermia(MH) is a rare and life-threatening pharmacogenetic disorder triggered by volatile anesthetics, the depolarizing muscle relaxant succinylcholine, and rarely by strenuous exercise or environmental heat. The exact prevalence of MH is unknown, and it varies from 1:16 000 in Denmark to 1:100 000 in New York State. The underlying mechanism of MH is excessive calcium release from the sarcoplasmic reticulum(SR),leading to uncontrolled skeletal muscle hyper-metabolism. Genetic mutations in ryanodine receptor type 1(RYR1)and CACNA1 S have been identified in approximately 50% to 86% and 1% of MH-susceptible(MHS) individuals,respectively. Classic clinical symptoms of MH include hypercarbia, sinus tachycardia, masseter spasm,hyperthermia, acidosis, muscle rigidity, hyperkalemia, myoglobinuria, and etc. There are two types of testing for MH: a genetic test and a contracture test. Contracture testing is still being considered as the gold standard for MH diagnosis. Dantrolene is the only available drug approved for the treatment of MH through suppressing the calcium release from SR. Since clinical symptoms of MH are highly variable, it can be difficult to establish a diagnosis of MH. Nevertheless, prompt diagnosis and treatments are crucial to avoid a fatal outcome. Therefore, it is very important for anesthesiologists to raise awareness and understand the characteristics of MH. This review summarizes epidemiology, clinical symptoms, diagnosis and treatments of MH and any new developments.

关键词： malignant hyperthermia general anesthesia dantrolene ryanodine receptor

malignant hyperthermia as a rare complication of local lidocaine injection:A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Anesthesiology 2023年第1期12卷 1-7页

作者： Mukosolu Florence Obi Manveer Ubhi Vikhyath Namireddy Chelsea Noel Manjari Sharma Frederick N.Campos Yash Garg Department of Internal Medicine Wyckoff Heights Medical CenterNew YorkNY 11237United States Department of Medicine St.Georges University School of MedicineTrue Blue 38902Grenada

BACKGROUND malignant hyperthermia(MH)is a hypermetabolic disorder of skeletal muscles triggered by exposure to volatile anesthetics and depolarizing muscular *** manifests with clinical presentations such as tachycardia,muscle rigidity,hyperpyrexia,and rhabdomyolysis in genetically predisposed individuals with ryanodine receptor or calcium voltage-gated channel subunit alpha1 S *** anesthetics,such as lidocaine,are generally considered safe;however,complications can arise,albeit *** administration has been reported to induce hypermetabolic reactions resembling MH in susceptible *** exact mechanism by which lidocaine might trigger MH is not fully *** some mechanisms are postulated,further research is needed for a better understanding of *** SUMMARY We present the case of MH in a 43-year-old male patient with an unknown genetic predisposition following a lidocaine injection during a dental *** case serves as a reminder that while the occurrence of lidocaine-induced MH is rare,lidocaine can still trigger this life-threatening ***,caution should be exercised when administering lidocaine to individuals who may be susceptible to *** is important to note that prompt intervention played a crucial role in managing the patient’s *** recognizing the early signs of MH,aggressive measures were initiated,including vigorous intravenous normal saline administration and *** to the effectiveness of these interventions,the administration of dantrolene sodium,a specific antidote for MH,was *** This case highlighted the significance of vigilant monitoring and swift action in mitigating the detrimental effects of lidocaine-induced *** should be exercised when administering lidocaine to individuals who may be predisposed to *** is very important to be aware and vigilant of the signs and symptoms of MH as early recognition and treatment intervention

关键词： malignant hyperthermia Tachyarrhythmia Lidocaine Local anesthesia Dantrolene sodium Genetic mutation Case report

Survey of Long-Term Sequelae in Survivors of a malignant hyperthermia Reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2016年第1期6卷 1-7页

作者： Kristian Werneid Barbara Brandom Department of Anesthesiology University of Pittsburgh Medical Center Pittsburgh PA USA Department of Anesthesiology Children’s Hospital of Pittsburgh Pittsburgh PA USA

BACKGROUND: malignant hyperthermia (MH) is a potentially fatal, autosomal dominant disorder associated with administration of volatile anesthetics and/or the depolarizing paralytic succinylcholine. Symptoms include muscle rigidity, tachycardia, elevated body temperature, and metabolic acidosis, which are secondary to accelerated skeletal muscle metabolism. MH susceptibility can be a chronic condition, and some MH susceptible patients may develop symptoms subsequent to anesthetic exposure. OBJECTIVE: This is the first study examining the sequelae of an MH event after hospital discharge. METHODS: A survey was sent to patients who voluntarily registered with the North American malignant hyperthermia Registry, which included questions on severity of symptoms predominating prior to the MH event, one month after the MH event, and presently on a scale of 1 - 10 with a free text option to expound further. Participants were also asked about their opinions on causality between MH and these symptoms. RESULTS: Twenty-three responses were analyzed (34.8% response rate). Participants were categorized by their age at the time of the MH event and years since the event. Most (83%) stayed in the ICU between 1 - 4 days, and 39% experienced the event over 25 years ago. While 43% did not attribute any long-term symptoms to their MH event, all others believed that certain symptoms were linked, including muscle pain (90%), muscle cramps (75%), muscle weakness (100%), back/joint pain (36%) and depression/anxiety (42%). CONCLUSIONS: Our study concluded that long-lasting morbidities may be attributed to an MH event. Chronic musculoskeletal symptoms are experienced by the majority of patients who experience acute MH.

关键词： malignant hyperthermia Retrospective Study Complications Neuromuscular Diseases

Study of the malignant hyperthermia RYR1 gene mutation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of the Malignant Hyperthermia RYR1 gene mutation

A Case Series on Central Core Disease in Pregnancy

中华口腔医学会第14次全国口腔医学学术会议（2012年...

作者： Baisheng Wang,Zhangui Tang,Lili Zhao,Shang Xie,Junqing Zhang,Yuan Li School of stomatology,Central South University

Objective:Through the gene sequencing of lip and palate cleft patients and Normal population RYR1 gene mutation sites c.1077,c.1668,c.2286, c.2943,c.7281,and with NCBI SNP database comparison,to analysis clinical

关键词： malignant hyperthermia cleft lip and palate genetics single nucleotide polymorphisms

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2022年第4期12卷 337-348页

作者： Sharadhi Channegowda Prajwal Shetty Ajith Wijesiriwardana North Cumbria Integrated Care NHS Foundation Trust Carlisle UK

Congenital myopathies are a group of minimally progressive or non-progressive neuromuscular conditions which is present from birth. A classical type of congenital myopathy is called central core disease. This condition is often confused with muscular dystrophy. Central core disease can be associated with comorbidities which affect pregnancy and its management. In this case series, we describe two cases, who are siblings affected by the same condition but at varied levels and their management during pregnancy. We also would like to illustrate a management plan for congenital myopathy during pregnancy, for a good maternal and fetal outcome.

关键词： Congenital Myopathy Central Core Disease Pregnancy Obstetric Management malignant hyperthermia