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Sex chromosomes behavior and G-banding treatment of male meiosis in nuptial gift-giving spiders of the family Trechaleidae

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Integrative Zoology 2011年第1期6卷 56-62页

作者： Maria J.ALBO Alicia POSTIGLIONI Laboratory of Ethology Ecology and EvolutionClemente Estable Biological Research InstituteMontevideoUruguay Department of Genetics and Animal Breeding Faculty of VeterinaryUniversity of the RepublicMontevideoUruguay

Preliminary genetic studies in Trechaleidae spider family show high variation in sex chromosomes and high heterocigocity,suggesting high chromatin *** trechaleids Paratrechalea ornata,Trechalea bucculenta and Trechaleoides biocellata are present in *** offering nuptial gifts during courtship have been reported in *** and *** but not in *** gifts are an inherited trait probably highly affected by environmental factors,which play an important role in gene *** hypothesize that this trait could be associated with tissue-specific genes existing in *** investigate the male meiosis in these 3 species,their sex chromosome system and the effects of G-banding on their chromosomes,and elucidate genetic differences among *** stages of the 3 species were submitted to Giemsa-staining and G-banding *** observed a haploid number of n=11 in *** and n=13 in both *** and *** from the 3 species presented an X_(1)X_(2)0 sex chromosome system,which is suggested as ancestral in *** *** and ***,both sex chromosomes were together and aligned in parallel until the segregation during anaphase *** contrast to these species,sex chromosomes of *** usually remained distant from each other until diakinesis when they were observed associated in parallel *** G-bands were similar in *** and ***,and they both differed from those in *** special behavior of sex chromosomes in *** as well as the different G-banding pattern of this species suggests the existence of novel modifications in this species.

关键词： G-banding male meiosis Neotropical spiders sex chromosomes Trechaleidae

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Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients

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Asian Journal of Andrology 2012年第4期14卷 580-583页

作者： Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku Department of Obstetrics and Gynecology Asahikawa Medical University Asahikawa Hokkaido 078-8510 Japan Department of Urology Osaka University Graduate School of Medicine Suita 565-0871 Japan Department of Integrated Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-1192 Japan Division of Community Medicine and Epidemiology Department of Health Science Asahikawa Medical University Asahikawa 078-8510 Japan

Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. meiosis is unique to germ cells and essential for reproduction. The synaptonemal complex is a critical component for chromosome pairing, segregation and recombination. Hormadl is essential for mammalian gametogenesis as knockout male mice are infertile. Hormadl-deficient testes exhibit meiotic arrest in the early pachytene stage and synaptonema! complexes cannot be visualized. To analyze the hypothesis that the human HORMAD1 gene defects are associated with human azoospermia caused by meiotic arrest, mutational analysis was performed in all coding regions by direct sequence analysis of 30 Japanese men diagnosed with azoospermia resulting from meiotic arrest. By the sequence analysis, three polymorphism sites, Single Nucleotide Polymorphism 1 （c. 163A〉G）, SNP2 （c. 501T〉G） and SNP3 （c. 918C〉T）, were found in exons 3, 8 and 10. The 30 patients with azoospermia and 80 normal pregnancy-proven, fertile men were analyzed for HORMAD1 polymorphisms. Both SNP1 and SNP2 were associated with human azoospermia caused by complete early meiotic arrest （P〈0.0S）. We suggest that the HORMAD1 has an essential meiotic function in human spermatogenesis.

关键词： azoospermia HORMAD1 male infertility male meiosis SNP

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