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Fabrication of a magnetite nanoparticle-loaded Polymeric Nanoplatform for Magnetically Guided Drug Delivery

Chemical Research in Chinese Universities 2013年第1期29卷 103-109页

作者： DING Guo-bin LIU Hui-yin WANG Yan LU Yan-yun WU Yi GUO Yi XU Li Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Life Science Jilin University Changchun 130012 P. R. China" College of Pharmacy Jilin University Changchun 130021 P. R. China School of Stomatology Dalian Medical University Dalian 116044 P. R. China

We developed a magnetite nanoparticle-loaded polymeric nanoplatform for magnetically guided 10- hydroxycamptothecin（HCPT） delivery. The nanoplatform was fabricated by simultaneously incorporating magnetite nanoparticles（NPs） and HCPT into the polymer micelle self-assembled from methoxy polyethylene glycolpoly（D,L-lactide-co-glycolide）（MPEG-PLGA） copolymer. Successful loading of HCPT into the nanoplatform was confirmed by Fourier transform infrared（FTIR） spectroscopy. Subsequently, we examined the in vitro antitumor efficacy of free HCPT and nanoplatform against three different cancer cell lines HeLa, A549 and HepG2. Flow cytometric analysis was condkt ,ucted to reveal the cell apoptosis caused by free HCPT and nanoplatform. Finally, the magnetic targeting property of the nanoplatform was evaluated by a self-designed in vitro experiment.

关键词： magnetite nanoparticle 10-Hydroxycamptothecin(HCPT) Nanoplatform Magnetic targeting

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SYNTHESIS AND CHARACTERIZATION OF SURFACE-HYPERBRANCHED magnetite nanoparticle FOR BOVINE SERUM ALBUMIN IMMOBILIZATION

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China Particuology 2004年第6期2卷 261-265页

作者： BifengPan FengGao HongchenGu EngineeringResearchCenterforNanoScienceandTechnology ShanghaiJiaoTongUniversityShanghai200030P.R.China

A hyperbranched polyamidoamine polymer was synthesized on the surface of magnetite nanoparticles to enhance bovine serum albumin (BSA) immobilization efficiency. The amount of immobilized bovine serum albumin (BSA) on the surface-hyperbranched magnetite nanoparticle was up to 2.5 times as much as that of magnetite nanoparticle modified with only amino silane.

关键词： hyperbranched magnetite nanoparticle bovine serum albumin (BSA) polyamidoamine

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Surface modification of Fe_3O_4 nanoparticles and their magnetic properties

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 226-229页

作者： Hao Yan Jian-cheng Zhang Chen-xia You Zhen-wei Song Ben-wei Yu Yue Shen School of Materials Science and Engineering Shanghai University Shanghai 200072 China

Fe3O4 magnetic nanoparticles were synthesized by the hydrothermal method, and the influences of the surfactant sodium bis（2-ethylhexyl） sulfosuecinate （AOT） on the particles were investigated. The structure, morphology, and magnetic properties of the products were characterized by X-ray powder diffraction （XRD）, transmission electron microscopy （TEM）, Fourier transform infrared spectroscopy （FT-IR）, and vibrating sample magnetometer （VSM）. It is confirmed that the as-prepared nanoparticles have been modified by using the surfactant during the synthesis process. The amount of the surfactant has an effect on the size, the dispersal, and the magnetic properties of the particles. Besides, the mechanisms of the influences were also discussed.

关键词： surfactant magnetite nanoparticle hydrothermal particle size dispersion magnetism

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