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maggot homogenate is associated with neural regeneration and wound healing in the rat

Neural Regeneration Research 2010年第8期5卷 623-629页

作者： Zhen Zhang Shouyu Wang Xiliang Tian Zexu Zhao Jianing Zhang Decheng Lv Department of Orthopedic Surgery First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Institute of Glycobiology Department of Biochemistry 'Dalian Medical University Dalian 116000 Liaoning Province China

BACKGROUND：Live delivery limits the clinical application of maggot therapy. To date in China, there are no in vivo reports regarding wound healing mechanisms of maggot therapy or the effects of maggot homogenate on wound nerve ***：To avoid complications due to the use of live maggots, an aseptic maggot homogenate was applied. Substance P （SP） and gene protein product 9.5 expression in a cutaneous wound was analyzed to explore possible mechanisms of neural regeneration and wound healing in the ***, TIME AND SETTING：A random grouping and controlled animal study was performed at the laboratory of the Department of Orthopedic Surgery, First Affiliated Hospital, Dalian Medical University from August 2008 to April ***：Live maggots were cultured and provided by the laboratory of the Department of Orthopedic Surgery of the First Affiliated Hospital, Dalian Medical University, ***：A total of 48 adult rats were selected and two acute, full-thickness wounds （round, 1.5 cm diameter） were created on the back of each rat. The two wounds were randomly assigned to homogenate product and control groups. Following two-step disinfection of maggots, a homogenate was produced from 10 maggots and applied to the wound area in the homogenate product group, while the wounds in the control group were treated with normal saline *** OUTCOME MEASURES：On days 1,3, 7, 10, 14, and 21 following injury, the wound tissue was excised. Histological examination of the wound was observed by hematoxylin and eosin staining or Masson＇s Trichrome staining. SP and protein gene product 9.5 expressions were examined by immunohistochemistry to evaluate wound neural ***：On days 7, 10, and 14, the rate of wound healing was significantly greater in the homogenate product group compared with the control group （P 〈 0.05）, and homogenate healing was better than that seen in the control group. On days 3, 7, and 10, SP expression in cells and regener

关键词： maggot therapy wound healing neuropeptides neural regeneration rats maggots maggot homogenate

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