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Chinese Journal of Chemical Engineering 2018年第9期26卷 1822-1828页

作者： Feng Xue Fugang Wang Shuai Chen Sheng Wang Shengui Ju Weihong Xing College of Chemical Engineering Nanjing Tech University

Adsorption operation is of great importance for separation and purification of semi-synthetic cephalosporin compounds in pharmaceutical industry. The adsorption dynamics of Cefoselis hydrochloride(CFH) on XR 920 C adsorbent in fixed bed was predicted by the model of modified film-pore diffusion(MFPD). The intraparticle diffusion equation and mass balance equation in fixed bed are discretized into two ordinary differential equations(ODEs) using the method of orthogonal collocation which largely improves the calculation accuracy. The MFPD model parameters including the pore diffusion coefficient(Dp), external mass-transfer coefficient(kf), and the axial dispersion(DL) were estimated. The kfvalue was calculated by the Carberry equation, in which the effective diffusion coefficient Dewas fitted based on Crank Model through experimental data. Moreover, three key operating parameters(i.e., initial adsorbate concentration; flow rate of import feed, and bed height of adsorbent) and the corresponded breakthrough curves were systematically studied and optimized. Therefore,this research not only provides valuable experimental data, but also a successfully mathematical model for designing the continuous chromatographic adsorption process of CFH.

关键词： Cefoselis hydrochloride Breakthrough curve Orthogonal collocation macroporous resin Fixed bed Simulation

ADSORPTION OF TANNIN ACID ONTO AN AMINATED macroporous resin FROM AQUEOUS SOLUTIONS

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Chinese Journal of Polymer Science 2007年第6期25卷 621-627页

作者： Yue Sun Ai-min Li Zheng-hao Fei Quan-xing Zhang Shi-he Wang Department of Municipal Engineering Southeast University Nanjing 210096 China Department of Environmental Engineering Nanjing University Nanjing 210093 China Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresourees and Environmental Protection Yancheng Teachers College Jiangsu 224002 China

A macroporous polymeric adsorbent NG-8 was synthesized with divinylbenzene using conventional suspension polymerization technique. Its aminated product NG-9 was prepared by introducing tertiary amino groups into NG-8 for removal of tannin acid from aqueous solutions. NG-9 could be used directly without a wetting process and had higher adsorption capacity than NG-8, which might be attributed to the enhanced adsorbent-adsorbate interaction due to the tertiary amino groups on the polymeric matrix. The Langmuir equation was successfully employed to describe the adsorption process. The adsorption enthalpy change further validated the uptake of tannin acid on NG-9 to be an enhanced physical adsorption because of the Lewis acid-base interaction. In addition, adsorption kinetic studies testified that the tertiary amino groups on the polymer matrix could decrease the adsorption rate maybe for the hindrance of the tertiary amino groups and water clusters built up.

关键词： macroporous resin Tannin acid Adsorption Thermodynamics Kinetics.

macroporous resin Adsorption for Purification of Flavonoids in Houttuynia cordata Thunb

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Chinese Journal of Chemical Engineering 2007年第6期15卷 872-876页

作者：张颖李淑芬吴希文赵星 Key Laboratory for Green Chemical Technology of State Education Ministry School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Flavonoids are one main kind of effective components in Houttuynia cordata Thunb., which display a wide range of pharmacological activity. In this study supercritical fluid extraction （SFE） with carbon dioxide was first used as preparat ion step to remove the volatile components, which are also active components, from Hout-tuynia cordata Thunb. Then ultrasound-assisted extraction was used to obtain the crude flavonoids and the macro-porous resin adsorption technology was further employed to purify the flavonoids. Nine kinds of macroporous resins with different properties were tested through static adsorption, and one macroporous resin labeled as D101 was selected. The effect of several factors, such as the ratio of column height to diameter, initial concentration and pH, on both flavonoids yield and content were explored by dynamic adsorption to obtain reasonable conditions of adsorption and desorption. The experimental results show that the content of fiavonoids can be above 60% with fia- vonoids recovery of 93.3 % under the optimum conditions of purification. HPLC analysis of the final flavonoids product shows it contains quercitrin, hypefin, rutin and quercetin.

关键词： flavonoids Itouttuynia cordata Thunb. macroporous resin adsorption supercritical fluid extraction

Extraction and purification of ustiloxin A from rice false smut balls by a combination of macroporous resin and high-speed countercurrent chromatography

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Food Production, Processing and Nutrition 2020年第1期2卷 287-299页

作者： Gang Wang Dan He Fengchun Zhao Junqiang Hu Yin-Won Lee Jianrong Shi Jianhong Xu Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and QualityMinistry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation(Nanjing)Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and NutritionJiangsu Academy of Agricultural SciencesNanjingPeople’s Republic of China School of Food and Biological Engineering Jiangsu UniversityZhenjiangPeople’s Republic of China Department of Microbiology College of Life ScienceKey Laboratory for Agriculture MicrobiologyShandong Agricultural UniversityTai’anPeople’s Republic of China School of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea

Rice false smut is an emerging plant disease *** A(UstA)is the major mycotoxin found in rice false smut balls,which are fungal colonies in rice *** this study,a new method consisting of macroporous resin column chromatography and high-speed countercurrent chromatography(HSCCC)was developed for UstA *** was extracted by a 3.81%HCOOH solution and adsorbed by XAD-4 *** was then eluted by a 40%methanol solution supplemented with 0.1%trifluoroacetic acid(TFA).Further purification was achieved by HSCCC using a two-phase solvent system consisting of n-butanol/TFA/H_(2)O(1/0.05/1,v/v/v).Under the optimized conditions,225 mg of UstA was obtained with a purity of 97.39%in a single run,with a final recovery of 65.2%.An inhibitory effect on seed germination of wheat and maize caused by UstA was observed in a preliminary phytotoxicity assay.

关键词： Ustiloxin A Rice false smut Preparative purification macroporous resin High-speed counter-current chromatography Phytotoxicity assay

Separation and purification of Arabinogalactan obtained from Larix gmelinii by macroporous resin adsorption

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Journal of Forestry Research 2007年第1期18卷 81-83页

作者： HUANG Zhan-hua FANG Gui-zhen ZHANG Bin Northeast Forestry University Key Laboratory of Bio-based Material Science and Technology Ministry of Education Harbin 150040 P. R. China

Arabinogalactan （AG） obtained from Larix gmelinii R. waS purified with the method of macroporous resin adsorption. Effects of various parameters on the adsorption, including adsorption time and temperature, the concentration and the dosage of raw AG the reused numbers of resin, were investigated. The effect of purification was tested through the removal rate of impurity and the contents of AG and impurity. The optimal condition was determined as follows： adsorbed at 30℃ for 2 h with the concentration of raw AG 〈0.1 g·mL^-1 and its dosage 〈 7 mL, the dose of resin was 3 g and reused for 4 times. On the basis of these, macroporous resin column was used for AG purification. The result showed that the AG yield could reach 68.28% with sugar content of 95.02%. The analysis of IR and UV showed that the effect of macroporous resin characteristics on the purification of AG was significant. The obtained product had the same functional groups with standard sample.

关键词： Arabinogalactan Larix gmelinii R. macroporous resin

ADSORPTION AND DESORPTION OF DSD ACID MANUFACTURING WASTEWATER ON macroporous resin

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Chinese Journal of Reactive Polymers 2001年第1期10卷 37-44页

作者： LONGChao ZHANG Quanxing XU Zhaoyi CHEN Jinlong LI Aimin CHENG Zhiqiang Department of Environmental Engineering School of the EnvironmentNanjing UniversityNanjing 210093China

4,4’-diaminostilbene-2, 2’-disulfonic acid (DSD acid) manufacturing wastewater was treated by a macroporous resin in a fixed-bed column. The results showed that this method was suitable for removal of chemical oxygen demands (COD) and color. About 91% COD and 99.5% color removal were obtained under the optimum adsorption conditions, i.e. temperature 20℃, flow rate 1bed volume/hour (BV/hr) and pH1-2. The resin was efficiently regenerated with aqueous sodium hydroxide and water. Furthermore, 65.5% of 4,4’-dinitrostilbene-2, 2’-disulfonic acid (DNS) could be recovered from wastewater for possible recycling to the manufacturing process. The adsorption capacity of resin remained constant during the repetition process of adsorption and desorption.

关键词： 4,4'-diaminostilbene-2, 2'-disulfonic acid macroporous resin Dye intermediate Wastewater treatment.

Preparation and quality assessment of high-purity ginseng total saponins by ion exchange resin combined with macroporous adsorption resin separation

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Chinese Journal of Natural Medicines 2014年第5期12卷 382-392页

作者： ZHAO Yu-Nan WANG Zhong-Li DAI Jian-Guo CHEN Lin HUANG Yu-Fang Key Laboratory of Brain Research Basic Medical College Nanjing University of Traditional Chinese Medicine

AIM： To prepare high-purity ginseng total saponins from a water decoction of Chinese ginseng ***： Total saponins were efficiently purified by dynamic anion-cation exchange following the removal of hydrophilic impurities by macroporous resin D101. For quality control, ultrahigh-performance liquid chromatography with a charged aerosol detector （CAD） was applied to quantify marker components. The total saponin content was estimated by a colorimetric method using a vanillin-vitriol system and CAD response. RESULTS： D201, which consisted of a cross-linked polystyrene matrix and -]N＋（CI-13）3 functional groups, was the best of the four anion exchange resins tested. However, no significant difference in cation exchange ability was observed between D001 （strong acid） and D 113 （weak acid）, although they have different functional groups and matrices. After purification in combination with D101, D201, and D 113, the estimated contents of total saponins were 107% and 90% according to the colorimetric method and CAD response, respectively. The total amount of representative ginsenosides Re, Rd, Rgl, and compound K was approximately 22% based on ultrahigh-performance liquid chromatography-CAD quantitative analysis. CONCLUSION： These findings suggest that an ion exchange resin, combined with macroporous adsorption resin separation, is a promising and feasible purification procedure for neutral natural polar components.

关键词： Panax ginseng Ginsenosides Ion exchange resin macroporous resin Quality assessment

Optimization of Preparative Separation and Purification of Total Flavonoids from Radix Puerariae by macroporous resin Method

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Journal of Chinese Pharmaceutical Sciences 2006年第2期15卷 121-126页

作者：刘火安王伯初戴传云邵志勇何从林贾云重庆大学生物工程学院 Interdepartment of Genetics Iowastate University Iowa 50011USA 重庆科技学院化学与生物工程学院

Aim To screen the optimum macroporous resin and conditions for the isolation and purification of flavonoids from Radix Puerariae. Methods The static and dynamic adsorption/desorption methods were used, and the separation and purification process was evaluated by measuring the concentration of total flavonoid in the fractions with UV spectrophotometer. Results The SP70 macroporous resin was the most effective compared with other macroporous resins. The optimum conditions were screened, which were 0.5 g· mL^- 1 corresponding to crude drug for concentration of extract, pH 5 - 6, and appended 60 times the volume of the resin bed （BV） with the adsorption speed 2 BV·h^-1, and the volume of aq. 70% （V/V） ethanol as eluant was 5 BV with desorption speed 2 BV·h^-1. By this method, the final contents of total flavonoids exceeded 80%. Conclusion The SP70 macroporous resin is the most effective one for large-scale isolation and purification of flavonoids from Radix Pueraria, which meets industrial needs.

关键词： Radix Puerariae total flavonoids macroporous resin separation purification

Static and dynamic studies of adsorption by four macroporous resins to enrich oridonin from Rabdosia rubescens

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Chinese Journal of Chemical Engineering 2021年第4期34卷 151-158页

作者： Ling Meng Xia Gui Zhi Yun College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 273400China

Oridonin,one of the active ingredients in Rabdosia rubescens(***),has been reported to induce cell apoptosis and cell cycle arrest in many *** extraction methods tend to result in unsatisfied enrichment and poor quality of oridonin present in a given *** paper aims to evaluate the performance and separation characteristics of four different macroporous resins to arrive at the most suitable methodology for the isolation and purification of highquality *** absorption kinetics,thermodynamic and dynamic adsorption were ***20 was selected for further study due to its high adsorption capacity of 32 mgg 1 and desorption ratio with 98.5%.The pseudosecondorder model was considered to be the most suitable for kinetic results,and Langmuir model was chosen to better describe the absorption *** optimum conditions(flow rate of 4 ml min 1,bed depth with 6 cm and initial concentration of 2.15 mg·ml^1),the effective content of oridonin increased from 33.9%to 79.1%in the dry extract with a recovery of 81%and the purity of oridonin improved from 76%to 93%.The results confirm that HP20 provides an efficient method to purify most oridonin from ***.

关键词： Rabdosia rubescens Oridonin macroporous resin Adsorption Kinetics Thermodynamics

Separation of salidroside from the fermentation broth of engineered Escherichia coli using macroporous adsorbent resins

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Chinese Journal of Chemical Engineering 2022年第4期35卷 260-267页

作者： Xiaocui Sun Xue Liu Guang-Rong Zhao Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Georgia Tech Shenzhen Institute Tianjin UniversityShenzhen 518071China

Salidroside(8-O-β-D-glucoside of tyrosol),a plant-derived natural product,is used for treatment of hypoxia,fatigue and aging *** availability of salidroside is restricted since it is extracted from3-5 years old Rhodiola roots,which grow very slowly in the cold region of northern hemisphere of *** laboratory has constructed an engineered Escherichia coli and established a fermentation process to produce salidroside from *** this article,nine macroporous resins from polarity to non-polarity,including NKA-9,S-8,AB-8,SP825,D101,LSA-8,LX-12,LX-18 and LX-68 resins,were tested to separate salidroside from fermentation *** static and dynamic experiments,the weakly polar SP825 resin had a better separation efficiency among nine *** adsorption kinetic and isotherm of salidroside on the SP825 resin were determined,and the pseudo-second-order kinetic model and Langmuir model could be fitted *** effects of the pH on adsorption and ethanol concentration on desorption were investigated,and an optimal separation process was *** adsorption for salidroside in the SP825 resin column was conducted with loading 150 ml at pH 7,and desorpted by washing 50 ml of80%ethanol *** the best process conditions,the purity and yield of salidroside in the final product were 91.6%and 74.0%,*** results showed that the macroporous SP825 resin would be feasible and effective to prepare salidroside and has promising application in the downstream process of microbial fermentation.

关键词： Adsorption Desorption Fermentation macroporous resin Salidroside