检索结果-南通市图书馆

检索条件"主题词=mTOR and autophagy"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Using proteomic approach to discover the treatment mechanism of（Z）3,4,5,4’-trans-tetramethoxystilbene for inhibition of gefitinib-resistant non-small cell lung cancer

Using proteomic approach to discover the treatment mechanism...

引用

第21届全国色谱学术报告会及仪器展览会

作者： Xing-Xing Fan Xiao-Jun Yao So Wei Xu Vincent Kam-Wai Wong Jian-Xing He Jian Ding Min Huang Jun Huang Da-Kai Xiao Ze-Bo Jiang Yan-Ling Zhou Richard Kin-Ting Kam Liang Liu Elaine Lai-Han Leung State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health Macau University of Science and Technology Guangzhou Institute of Respiratory Disease State Key Laboratory of Respiratory DiseaseThe 1st Affiliated Hospital of Guangzhou Medical College State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academic of Sciences Department Chemical Pathology Faculty of Medicinethe Chinese University of Hong Kong

Calcium is a second messenger which is required for regulation of many cellular processes. However,excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such,selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently,we have identified an effective analogue of resveratrol,（Z）3,4,5,4’-trans-tetramethoxystilbene（TMS） which selectively elevated the intracellular calcium level in gefitinib-resistant（G-R） non-small-cell lung cancer（NSCLC） cells. TMS exhibited significantly inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR was inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum（ER） stress and AMPK activation. Using i TRAQ proteomics analysis,we have further confirmed that mtor pathway, which is the downstream of AMPK, was significantly suppressed by TMS. JNK, the cross-linker of ER stress and mtor pathway was significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together,TMS showed promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients.

关键词： (Z)3,4,5,4’-trans-tetramethoxystilbene(TMS) non-small-cell lung cancer gefitinib resistance mtor and autophagy

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：