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Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis

International Journal of Ophthalmology(English edition) 2014年第3期7卷 550-556页

作者： Wen Sun Yan Sheng Yu Weng Chun-Xiao Xu Susan E.I.Williams Yu-Tao Liu Michael A.Hauser R.Rand Allingham Ming-Juan Jin Guang-Di Chen Department of Ophthalmology the First Affiliated HospitalZhejiang University School of Medicine Department of Clinical Laboratory Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Public Health Zhejiang University School of Medicine Division of Ophthalmology Department of NeurosciencesUniversity of the Witwatersrand Center for Human Genetics Duke University Medical Center Durham North Carolina 27710 USA Department of Ophthalmology Duke University Eye CenterDurham North Carolina 27710 USA

AIM:To study the associations between lysyl oxidaselike 1(LOXL1)polymorphisms and primary open angle glaucoma(POAG)remain *** this study,we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG ***:Published literature from PubMed and other databases were *** studies evaluating the association between LOXL1 polymorphisms(rs2165241,rs1048661,rs3825942)and POAG risk were *** odds ratio(OR)and 95%confidence interval(CI)were calculated using random-or fixed-effects ***:Twelve studies were identified as eligible articles,with thirteen(2098 cases and 16 473 controls),thirteen(1795 cases and 2916 controls)and sixteen population cohorts(2456 cases and 2846 controls)for the association of rs2165241,rs1048661 and rs3825942with POAG risk *** analyses showed noassociation between each LOXL1 polymorphism and POAG risk,and the negative associations were remained when the subjects were stratified as Caucasian and *** heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations(TC vs CC:OR,0.79,95%CI:0.63-0.99),and rs1048661was associated with increased POAG risk in hospitalbased populations in a dominant model(TT vs CC+CT:OR,1.23,95%CI:1.01-1.50);however,these associations were not found in population-based ***:This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG *** the limited sample size,the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation.

关键词： glaucoma gene polymorphism metaanalysis lysyl oxidase-like 1

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The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 148-156页

作者： Qing-Shan Ji Bing Qi Yue-Chun Wen Lian Liu Xiao-Ling Guo Guo-Cheng Yu Jing-Xiang Zhong Department of Ophthalmology Affiliated Anhui Provincial Hospital of Anhui Medical University Department of Ophthalmology the First Affiliated Hospital of Jinan University Department of Cell Biology the Cell Biology Institute of Jinan University

AIM: To investigate the association of lysyl oxidaselike 1(LOXL1) single nucleotide polymorphisms(SNPs)with exfoliation syndrome(XFS)/exfoliation glaucoma(XFG).METHODS: Published manuscripts from Pub Med and EMBASE were identified until May 2014. Summary odds ratios(ORs) and 95% confidence intervals(CIs) for LOXL1(rs1048661, rs2165241 and rs3825942) polymorphisms and the risk of XFS/XFG were estimated using random-or fixed- effect model.· RESULTS: The three LOXL1 polymorphisms(rs1048661, rs3825942, and rs2165241) were associated with an increased risk for XFS/XFG among Caucasians,with OR 2.19(1.96-2.45), 8.8(6.05-12.79) and 3.41(3.11-3.73), respectively. On the contrast, the rs1048661 and rs2165241, but not rs3825942 polymorphism, have a potential protective effect on XFS/XFG in Asians, with OR0.06(0.02-0.18), 0.15(0.09-0.25), ***: There is strong evidence that LOXL1 polymorphisms are associated with XFS/XFG risk. The strength of risk might be ethnicity-dependent.

关键词： lysyl oxidase-like 1 polymorphism exfoliation syndrome glaucoma Meta-analysis

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