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Prognostic values of interim and post-therapy ^(18)F-FDG PET/CT scanning in adult patients with Burkitt's lymphoma

Chinese Journal of Cancer 2015年第12期34卷 608-613页

作者： Wen-Xiao Wei Jia-Jia Huang Wen-Yu Li Xu Zhang Yi Xia Wen-Qi Jiang Wei Fan Zhi-Ming Li State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Medical Oncology Sun Yat-sen University Cancer Center lymphoma Division Cancer CenterGuangdong General HospitalGuangdong Academy of Medical Sciences Department of Nuclear Medicine Sun Yat-sen University Cancer Center

Background:The prognostic values of interim and post-therapy fluorine-18-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography(PET) and PET/computed tomography(CT) scanning have been confirmed in several subtypes of ***,its prognostic value in Burkitt's lymphoma has not been clearly *** aim of the present study was to assess the prognostic value of PET/CT scanning during different treatment processes of Burkitt's ***:A total of 29 adult patients with newly diagnosed Burkitt's lymphoma were retrospectively involved in this study;of them,23 patients underwent baseline PET/CT,15 patients underwent mid-therapy PET/CT after 1-4 cycles of chemotherapy,and 17 patients underwent post-therapy PET/CT after all planned first-line chemotherapy ***-therapy and post-therapy PET/CT results(positive ***) were visually interpreted according to the criteria of the International Harmonization *** reduction in the maximum standardizes uptake values(ASUVmax)of 25%,50%,and 75%were regarded as cutoff *** survival(OS) and progression-free survival(PFS) were regarded as the major ***:The median OS and PFS were 27.6 months(range 6.5-78.3 months) and 27.2 months(range 3.0-78.3 months),*** median SUVmax of the baseline PET/CT was 18.3(range 1.6-35.9),whereas the median SUVmax of the mid-therapy and post-therapy PET/CT decreased to 4.0(range 0-17.6) and 3.0(range 0-14.5),*** patients' Eastern Cooperative Oncology Group(ECOG) scores(lymphoma was 50%(P = 0.019).Conclusions:^(18)F-FDG uptake was intense in Burkitt's lymphoma,and there was a significant reduction in SU

关键词： Burkitt's lymphoma, Mid-therapy PET/CT, Post-therapy PET/CT, Prognosis, Adult patients

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SHMTI C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma： evidence from 7309 patients

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Chinese Journal of Cancer 2015年第12期34卷 573-582页

Background Serine hydroxymethyltransferase 1 （SHMT1） is a key enzyme in the folate metabolic pathway thatplays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormalbiosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Manyepidemiologic studies have explored the association between C1420T polymorphism and the risk of non-Hodgkinlymphoma （NHL）, but the results have been ***, we performed this meta-analysis to evaluate ***： The meta-analyses were conducted to evaluate the effect of SHMT1 C1420T polymorphism on NHL *** ratios （ORs） and 95% confidence intervals （CIs） were calculated to measure the strength of the ***： Eight studies encompassing 3232 cases and 4077 controls were included. A statistically significant associationwas found between SHMT1 C1420T polymorphism and NHL risk under the allelic comparison （T vs. C： OR = 1.09,95% Cl 1.01-1.17）; a borderline association was found between SHMT1 C1420T polymorphism and NHL risk under thehomozygote model （TT vs. CC： OR = 1.18,95% Cl 1.00-1.39） and the dominant model （CT＋TT vs. CC： OR = 1.10,95%Ci 1.00-1.21）.Conclusion： SHMT1 C1420T polymorphism may be associated with NHL risk, which needs to be validated in large,prospective studies.

关键词： Serine hydroxymethyltransferase 1 (SHMT1), Polymorphism, Non-Hodgkin lymphoma, Meta-analysis

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