检索结果-南通市图书馆

Serum Amyloid A Protein: A Potential Biomarker Correlated With Clinical Stage of lung cancer

Biomedical and Environmental Sciences 2007年第1期20卷 33-40页

作者： DAN-HUI LIU XIAO-MIN WANG LI-JUAN ZHANG SONG-WEI DAI LI-YUN LIU JI-FU LIU SHAN-SHAN WU SHUAN-YING YANG SAM FU XUE-YUAN XIAO DA-CHENG HE Key Laboratory of Cell Proliferation and Regulation of Ministry of Education Beijing Normal University Beijing 100875 China Department of Thoracic Surgery General Hospital of Beijing Command PLA Beijing 100700 China Department of Respiratory Medicine Second Hospital of Xi＇an Jiaotong University Xi＇an 710004 Shaanxi China Ciphergen Biosystems Inc. Fremont CA 94555 USA

Objective To identify serum diagnosis or progression biomarkers in patients with lung cancer using protein chip profiling analysis. Method Profiling analysis was performed on 450 sera collected from 213 patients with lung cancer, 19 with pneumonia, 16 with pulmonary tuberculosis, 65 with laryngeal carcinoma, 55 with laryngopharyngeal carcinoma patients, and 82 normal individuals. A new strategy was developed to identify the biomarkers on chip by trypsin pre-digestion. Results Profiling analysis demonstrated that an 11.6kDa protein was significandy elevated in lung cancer patients, compared with the control groups （P〈0.001）. The level and percentage of 11.6kDa protein progressively increased with the clinical stages Ⅰ-Ⅳ and were also higher in patients with squamous cell carcinoma than in other subtypes. This biomarker could be decreased after operation or chemotherapy. On the other hand, 11.6kDa protein was also increased in 50% benign diseases of lung and 13% of other cancer controls. After trypsin pre-digestion, a set of new peptide biomarkers was noticed to appear only in the samples containing a 11.6kDa peak. Further identification showed that 2177Da was a fragment of serum amyloid A （SAA, MW 11.6kDa）. Two of the new peaks, 1550Da and 1611Da, were defined from the same protein by database searching. This result was further confirmed by partial purification of 11.6kDa protein and MS analysis. Conclusion SAA is a useful biomarker to monitor the progression of lung cancer and can directly identify some biomarkers on chip.

关键词： lung cancer Serum amyloid A On chip identification Surface enhanced laser desorption/ionization Biomarker

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells

引用

Chinese Journal of Natural Medicines 2020年第7期18卷 517-525页

作者： CHEN Yu-Chi HUANG Mu-Yang ZHANG Le-Le FENG Zhe-Ling JIANG Xiao-Ming YUAN Luo-Wei HUANG Run-Yue LIU Bo YU Hua WANG Yi-Tao CHEN Xiu-Ping LIN Li-Gen LU Jin-Jian State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China School of Medicine Chengdu UniversityChengdu 610106China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) Guangzhou 510120China

Nagilactone E(NLE),a natural product with anticancer activities,is isolated from Podocarpus *** this study,we reported that NLE increased programmed death ligand 1(PD-L1)expressions at both protein and mRNA levels in human lung cancer cells,and enhanced its localization on the cell ***,NLE increased the phosphorylation and expression of cJun,and promoted the localization of c-Jun in the nucleus,while silencing of c-Jun by small interfering RNA(siRNA)reduced NLEinduced *** study showed that NLE activated the c-Jun N-terminal kinases(JNK),the upstream of c-Jun,and its inhibitor SP600125 reversed the NLE-increased ***,NLE-induced PD-L1 increased the binding intensity of PD-1 on the cell *** summary,NLE upregulates the expression of PD-L1 in lung cancer cells through the activation of JNK-c-Jun axis,which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer.

关键词： Programmed death ligand 1 Nagilactone E lung cancer c-Jun JNK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of factors influencing skip lymphatic metastasis in pN_2 non-small cell lung cancer

引用

Chinese Journal of cancer Research 2012年第4期24卷 340-345页

作者： Gui-Long Li Yong Zhu Wei Zheng Chao-Hui Guo Chun Chen Department of Thoracic Surgery Fujian Medical University Union Hospital

Objective： Although many clinical studies on skip lymphatic metastasis in non-small cell lung cancer have been reported, the risk factors for skip lymphatic metastasis are still controversy and debatable. This study investigated, by multivariate logistic regression analysis, the clinical features of skip metastasis to mediastinal lymph nodes （N2） in non-small cell lung cancer 0NISCLC） patients. Methods： We collected the clinicopathological data of 256 pN2-NSCLC patients who underwent lobectomy plus systemic lymph node dissection in Fujian Medical University Union Hospital. The cases in the present study were divided into two groups： skip metastasis （N2 skip＋） and non- skip metastasis （N2 skip-）. A retrospective analysis of clinical pathological features of two groups was performed, rib determine an independent factor, multivariate logistic regression analysis was used to identify possible risk factors. Results： A total of 256 pN2-NSCLC patients were recruited. The analysis results showed that gender, pathologic types, surgery, pleural involvement, smoking history, age, tumor stages, and differentiation were not statistical significant factors impacting on skip metastasis in pN2-NSCLC （P〉0.05）, whereas tumor size was an independent factor for skip metastasis （P=0.02）. Conclusions： The rate of skip lymphatic metastasis increases in pN2-NSCLC patients, in accompany with an increased tumor size.

关键词： lung cancer lymph node skip metastasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer

引用

cancer Biology & Medicine 2018年第3期15卷 228-237页

作者： Xiao Yu Xiaofei Ye Hongyan Lin Nannan Feng Sumeng Gao Xiaohong Zhang Yu Wang Herbert Yu Xiaobei Deng Biyun Qian Hongqiao International Institute of Medicine Shanghai Tongren Hospital and Faculty of Public Health Shanghai Jiao Tong University School of Medicine cancer Epidemiology Program University of Hawaii Cancer Center

Objective: Long non-coding RNAs(lnc RNAs) are involved in numerous biological processes in lung cancer cells. In our previous studies, we identified a lnc RNA, ENST00000439577, which is highly expressed in lung carcinomas, and termed it lung cancer progression-associated transcript 1(LCPAT1). To characterize the role of LCPAT1 in lung cancer, we conducted the current ***: Expression of LCPAT1 and autophagy-associated markers in tumor tissues and lung cancer cell lines was determined by real-time quantitative polymerase chain reaction(q PCR). Hematoxylin and eosin(HE) staining, q PCR, Western blot, and immunohistochemistry were performed to evaluate xenografted tumor tissues. Autophagy induced by rapamycin was detected by Western blot and immunofluorescence in lung cancer cell ***: Expression of LCPAT1 and microtubule-associated protein 1 light chain 3 beta(LC3B) was positively correlated in lung cancer. Knockdown of LCPAT1 inhibited tumor growth and suppressed cell autophagy in vivo. Moreover, LCPAT1 knockdown in lung cancer cell lines resulted in decreased autophagy-associated gene expression and alleviated the cell autophagy induced by ***: We speculate that LCPAT1 plays a crucial role in regulating autophagy in lung cancer.

关键词： lung cancer autophagy long non-coding RNA LCAPT1 ENST00000439577

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

引用

cancer Biology & Medicine 2022年第7期19卷 1047-1060页

作者： Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue Yanlei Liu Jesús M.de la Fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of EducationShanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science&EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Center for Nanotechnology Collaborative Innovational Center for System BiologyShanghai 200241China Department of Neurosurgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Instituto de Nanociencia de Aragon(INA) Universidad de ZaragozaZaragoza 50018Spain

Objective:Although great progress has been made in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA ***:We developed an up-conversion nanoparticle-based nanocage *** system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites,due to modifications of targeted molecules on the surfaces of nanocages and local ***:The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites,where they *** with the passive target and control groups,the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of ***:The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor *** with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes,high tumor inhibition ratios,and longer survival times.

关键词： Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deer Hunting Optimization with Deep Learning Model for lung cancer Classification

引用

Computers, Materials & Continua 2022年第10期73卷 533-546页

作者： Mahmoud Ragab Hesham A.Abdushkour Alaa F.Nahhas Wajdi H.Aljedaibi Information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Artificial Intelligence for Precision Medicines King Abdulaziz UniversityJeddah 21589Saudi Arabia Mathematics Department Faculty of ScienceAl-Azhar UniversityNaser City 11884CairoEgypt Nautical Science Department Faculty of Maritime StudiesKing Abdulaziz UniversityJeddah21589Saudi Arabia Biochemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Computer Science Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah 21589Saudi Arabia

lung cancer is the main cause of cancer related death owing to its destructive nature and postponed detection at advanced *** recognition of lung cancer is essential to increase the survival rate of persons and it remains a crucial problem in the healthcare *** aided diagnosis(CAD)models can be designed to effectually identify and classify the existence of lung cancer using medical *** recently developed deep learning(DL)models find a way for accurate lung nodule classification ***,this article presents a deer hunting optimization with deep convolutional neural network for lung cancer detection and classification(DHODCNNLCC)*** proposed DHODCNN-LCC technique initially undergoes pre-processing in two stages namely contrast enhancement and noise ***,the features extraction process on the pre-processed images takes place using the Nadam optimizer with RefineDet *** addition,denoising stacked autoencoder(DSAE)model is employed for lung nodule ***,the deer hunting optimization algorithm(DHOA)is utilized for optimal hyper parameter tuning of the DSAE model and thereby results in improved classification *** experimental validation of the DHODCNN-LCC technique was implemented against benchmark dataset and the outcomes are assessed under various *** experimental outcomes reported the superior outcomes of the DHODCNN-LCC technique over the recent approaches with respect to distinct measures.

关键词： lung cancer image classification computer aided diagnosis deep learning medical imaging parameter optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of regulators of RNA m6A methylation in lung cancer

引用

Genes & Diseases 2023年第2期10卷 495-504页

作者： Qicheng Zhang Ke Xu Tianjin Key Laboratory of lung cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China

N6 -methyladenosine (m6 A) modification is found the most prevalent and abundant post-transcriptional mRNA modification in eukaryotic cells. It regulates almost all stages of RNA life cycle including splicing, translocation, stability, decay and translation. As a dynamic and reversible process, m6 A modification is catalyzed by the RNA methyltransferases (‘writers’), removed by the demethylases (‘erasers’), and interacts with m6 A-binding proteins (‘readers’). Recent studies have revealed that these m6 A modification regulators are frequently expressed aberrantly in various types of cancer, and involved in cell proliferation, differentiation, metabolism, particularly, in tumorigenesis and tumor progression through diverse mechanisms. In this review, the m6 A modification process and its regulatory functions in lung cancer are summarized. Furthermore, the research progress in the inhibitor development of m6 A modification, and the potential of targeting m6 A modifying proteins for clinical application are discussed.

关键词： Eraser lung cancer N6-methyladenosine Reader Writer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nkx2-1:a novel tumor biomarker of lung cancer

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 855-866页

作者： LiYANG Min LIN Wen-jing RUAN Liang-liang DONG En-guo CHEN Xiao-hong WU Ke-jing YING Department of Respiratory Medicine the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006 China Department of Radiology the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 China Key Laboratory of Biotherapy of Zhejiang Province Department of Respiratory Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

关键词： Nkx2-1 TTF-1 lung cancer Biomarker Diagnosis Prognosis Therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

lung cancer Risk Attributable to Active Smoking in China:A Systematic Review and Meta-Analysis

引用

生物医学与环境科学:英文版 2023年第9期36卷 850-861页

作者： ZHAO Jian SHI Yu Lin WANG Yu Tong AI Fei Ling WANG Xue Wei YANG Wen Yi WANG Jing Xin AI Li Mei HU Kui Ru WAN Xia Department of Epidemiology and Biostatistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

Objective No consensus exists on the relative risk(RR)of lung cancer(LC)attributable to active smoking in *** study aimed to evaluate the unified RR of LC attributable to active smoking among the Chinese *** A systematic literature search of seven databases was conducted to identify studies reporting active smoking among smokers versus nonsmokers in *** articles on LC providing risk estimates with their 95%confidence intervals(CIs)for“ever”“former”or“current”smokers from China were ***-analysis was used to estimate the pooled RR of active *** Forty-four unique studies were *** with that of nonsmokers,the pooled RR(95%CI)for“ever”“former”and“current”smokers were 3.26(2.79–3.82),2.95(1.71–5.08),and 5.16(2.58–10.34)among men,3.18(2.78–3.63),2.70(2.08–3.51),and 4.27(3.61–5.06)among women,and2.71(2.12–3.46),2.66(2.45–2.88),and 4.21(3.25–5.45)in both sexes combined,*** The RR of LC has remained relatively stable(range,2–6)over the past four decades in *** quitting of smoking could reduce the RR to some extent;however,completely refraining from smoking is the best way to avoid its adverse effects.

关键词： Active smoking Chinese population lung cancer Systematic review Meta-analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

引用

Frontiers of Medicine 2023年第4期17卷 714-728页

作者： Tianzhuo Wang Huiying Guo Lei Zhang Miao Yu Qianchen Li Jing Zhang Yan Tang Hongquan Zhang Jun Zhan Program for cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesBeijing 100191China Peking University International cancer Institute Beijing 100191China MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science CenterBeijing 100191China

FRMD6,a member of the 4.1 ezrin-radixin-moesin domain-containing protein family,has been reported to inhibit tumor progression in multiple ***,we demonstrate the involvement of FRMD6 in lung cancer *** find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung *** addition,the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma(n=75,P=0.0054)and lung adenocarcinoma(n=94,P=0.0330).Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of ***,FRMD6 interacts and colocalizes with mTOR and S6K,which are the key molecules of the mTOR signaling ***6 markedly enhances the interaction between mTOR and S6K,subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer ***,knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6^(−/−)gene KO MEFs and ***,our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6 lung cancer mTOR pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：