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Mechanism of hepatocellular damage in rat caused by low serum selenium

Frontiers of Medicine 2008年第3期2卷 255-258页

作者： Yi LU Bo QU Chang LIU Liang YU Xuemin LIU Haohua WANG An JIANG Xiaogang ZHANG Department of Hepatobiliary Surgery The First Affiliated HospitalSchool of MedicineXi’an Jiaotong UniversityXi’an 710061China

The aim of this paper is to investigate the mechanism of hepatocellular damage in rats caused by low serum *** six rats were randomly divided into 2 groups:group A(fed with low-selenium diet from the Keshan Disease area with the content of selenium being 0.017 mg/kg);group B[fed with sel-enium-supplemented diet and 0.3 mg/L selenium(Na_(2)SeO_(3))was added to the drinking water].Both were respectively fed for 12 *** the end of the 12th week,the levels of serum selenium,glutathione peroxidase(GPX)and malondialdehyde(MDA)in hepatic tissue were measured;the hepatocellular ultrastructure and apoptosis were observed as *** levels of serum sel-enium and GPX in group A were markedly lower than those in group *** level in group A was significantly higher than that in group *** the electron micro-scope(EM),the mitochondria were remarkably changed in group *** rate of liver cell apoptosis appeared much higher in group A as *** indicated that the damage caused by selenium deficiency was through the process of *** deficiency led to apoptosis of hepa-tocytes where oxidative damage to mitochondria might be the cause.

关键词： low-selenium hepatocyte oxidative damage mitochondria apoptosis

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