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Effects of cervical low-frequency electrical stimulation with various waveforms and densities on body mass,liver and kidney function,and death rate in ischemic stroke rats

引用

Neural Regeneration Research 2011年第4期6卷 304-308页

作者： Yonghong Yang Chengqi He Lin Yang Qiang Gao Shasha Li Jing He Department of Rehabilitation Medicine West China Hospital Sichuan University Key Laboratory of Rehabilitation Medicine of SichuanProvince Chengdu 610041 Sichuan Province China

low-frequency electrical stimulation has resulted in favorable effects in the treatment of post-stroke dysphagia. However, the safety of cervical low-frequency electrical stimulation remains unclear because of numerous nerves and blood vessels in the neck. In the present study, rats with ischemic stroke underwent low-frequency electrical stimulation, and systemic and local effects of electrical stimulation at different densities and waveforms were investigated. electrical stimulation resulted in no significant effects on body mass, liver or kidney function, or mortality rate. In addition, no significant adverse reaction was observed, despite overly high intensity of low-frequency electrical stimulation, which induced laryngismus, results from the present study suggested that it is safe to stimulate the neck with a low-frequency electricity under certain intensities.

关键词： adverse reaction deglutition rehabilitation low-frequency electrical stimulation ischemic stroke: rats

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Changes in plasma calcitonin gene-related peptide and serum neuron specific enolase in rats with acute cerebral ischemia after low-frequency electrical stimulation with different waveforms and intensities

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Neural Regeneration Research 2011年第28期6卷 2217-2221页

作者： Qiang Gao Yonghong Yang Shasha Li Jing He Chengqi He Department of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine of Sichuan Province West China Hospital SichuanUniversity Chengdu 610041 Sichuan Province China

Following acute cerebral ischemia in rats, plasma calcitonin gene-related peptide decreased and the level of serum neuron specific enolase and the volume of the infarction increased. Square-wave and triangular-wave electrical stimulation with low or high intensities could increase the plasma calcitonin gene-related peptide, decrease the serum neuron specific enolase and reduce the infarction volume in the brain in rats with cerebral ischemia. There was no significant difference between different wave forms and intensities. The experimental findings indicate that low-frequency electrical stimulation with varying waveforms and intensities can treat acute cerebral ischemia in rats.

关键词： low-frequency electrical stimulation acute cerebral ischemia calcitonin gene-related peptide neuron specific enolase infarction volume

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