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Fast Solution Method for the Large-scale Unit Commitment Problem with long-term storage

Chinese Journal of Electrical Engineering 2023年第3期9卷 39-49页

作者： Bo Li Chunjie Qin Ruotao Yu Wei Dai Mengjun Shen Ziming Ma Jianxiao Wang School of Electrical Engineering Guangxi UniversityNanning 530004China State Grid Sichuan Electric Power Company Chengdu 610041China National Power Dispatching and Control Center State Grid Corporation of ChinaBeijing 100031China National Engineering Laboratory for Big Data Analysis and Applications(Peking University) Beijing 100871China

long-term storage(LTS)can provide various services to address seasonal fluctuations in variable renewable energy by reducing energy curtailment.However,long-term unit commitment(UC)with LTS involves mixed-integer programming with large-scale coupling constraints between consecutive intervals(state-of-charge(SOC)constraint of LTS,ramping rate,and minimum up/down time constraints of thermal units),resulting in a significant computational burden.Herein,an iterative-based fast solution method is proposed to solve the long-term UC with LTS.First,the UC with coupling constraints is split into several sub problems that can be solved in parallel.Second,the solutions of the sub problems are adjusted to obtain a feasible solution that satisfies the coupling constraints.Third,a decoupling method for long-term time-series coupling constraints is proposed to determine the global optimization of the SOC of the LTS.The price-arbitrage model of the LTS determines the SOC boundary of the LTS for each sub problem.Finally,the sub problem with the SOC boundary of the LTS is iteratively solved independently.The proposed method was verified using a modified IEEE 24-bus system.The results showed that the computation time of the unit combination problem can be reduced by 97.8%,with a relative error of 3.62%.

关键词： Constraint splitting long-term storage mix-integer programming unit commitment

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long-term storage of lipid-like nanoparticles for mRNA delivery

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Bioactive Materials 2020年第2期5卷 358-363页

作者： Pengxuan Zhao Xucheng Hou Jingyue Yan Shi Du Yonger Xue Wenqing Li Guangya Xiang Yizhou Dong Division of Pharmaceutics&Pharmacology College of PharmacyThe Ohio State UniversityColumbusOH43210United States School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Biomedical Engineering The Ohio State UniversityColumbusOH43210United States The Center for Clinical and Translational Science The Ohio State UniversityColumbusOH43210United States The Comprehensive Cancer Center The Ohio State UniversityColumbusOH43210United States Dorothy M.Davis Heart&Lung Research Institute The Ohio State UniversityColumbusOH43210United States Department of Radiation Oncology The Ohio State UniversityColumbusOH43210United States

Lipid-like nanoparticles(LLNs)have been extensively explored for messenger RNA(mRNA)delivery in various biomedical applications.However,the long-term storage of these nanoparticles is still a challenge for their clinical translation.In this study,we investigated a series of conditions for the long-term storage of LLNs with encapsulation of mRNA.We evaluated the stability of LLNs with different concentrations of cryoprotectants(sucrose,trehalose or mannitol)under the conditions of freezing or lyophilization processes.Through in vitro and in vivo mRNA delivery studies,we identified the optimal storage condition,and found that the addition with 5%(w/v)sucrose or trehalose to LLNs could remain their mRNA delivery efficiency for at least three months in the liquid nitrogen storage condition.

关键词： Lipid-like nanoparticles mRNA delivery long-term storage

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How old is too old? In vivo engraftment of human peripheral blood stem cells cryopreserved for up to 18 years-implications for clinical transplantation and stability programs

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World Journal of Stem Cells 2020年第5期12卷 359-367页

作者： John Underwood Mahvish Rahim Carijo West Rebecca Britton Elaine Skipworth Vicki Graves Steven Sexton Hillary Harris Dave Schwering Anthony Sinn Karen E Pollok Kent A Robertson W Scott Goebel Kerry M Hege Departments of Internal Medicine and Pediatrics Indiana University School of MedicineIndianapolisIN 46202United States Department of Pediatrics Division of Pediatric Hematology/OncologyIndiana University School of MedicineIndianapolisIN 46202United States Cellular Therapy Laboratory Indiana University HealthIndianapolisIN 46202United States Department of Pediatrics Herman B Wells Center for Pediatric ResearchIn Vivo Therapeutics Core and Angio Biocore Shared Resource Facilities for the Indiana University Simon Cancer CenterIndiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND Peripheral blood stem cells(PBSC)are commonly cryopreserved awaiting clinical use for hematopoietic stem cell transplant.long term cryopreservation is commonly defined as five years or longer,and limited data exists regarding how long PBSC can be cryopreserved and retain the ability to successfully engraft.Clinical programs,stem cell banks,and regulatory and accrediting agencies interested in product stability would benefit from such data.Thus,we assessed recovery and colony forming ability of PBSC following long-term cryopreservation as well as their ability to engraft in NOD/SCID/IL-2 Rγnull(NSG)mice.AIM To investigate the in vivo engraftment potential of long-term cryopreserved PBSC units.METHODS PBSC units which were collected and frozen using validated clinical protocols were obtained for research use from the Cellular Therapy Laboratory at Indiana University Health.These units were thawed in the Cellular Therapy Laboratory using clinical standards of practice,and the pre-freeze and post-thaw characteristics of the units were compared.Progenitor function was assessed using standard colony-forming assays.CD34-selected cells were transplanted into immunodeficient mice to assess stem cell function.RESULTS Ten PBSC units with mean of 17 years in cryopreservation(range 13.6-18.3 years)demonstrated a mean total cell recovery of 88%±12%(range 68%-110%)and post-thaw viability of 69%±17%(range 34%-86%).BFU-E growth was shown in 9 of 10 units and CFU-GM growth in 7 of 10 units post-thaw.Immunodeficient mice were transplanted with CD34-selected cells from four randomly chosen PBSC units.All mice demonstrated long-term engraftment at 12 wk with mean34%±24%human CD45+cells,and differentiation with presence of human CD19+,CD3+and CD33+cells.Harvested bone marrow from all mice demonstrated growth of erythroid and myeloid colonies.CONCLUSION We demonstrated engraftment of clinically-collected and thawed PBSC following cryopreservation up to 18 years in NSG mice,signifying likely successful clinical transplantatio

关键词： Colony-forming units assay Cryopreservation Hematopoietic stem cells Hematopoietic stem cell transplantation In vitro techniques Peripheral blood stem cell Viability Transplant long-term storage

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