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Red AIE conjugated polyelectrolytes for long-term tracing and image-guided photodynamic therapy of tumors

Science China Chemistry 2020年第12期63卷 1815-1824页

作者： Hongming Yao Jun Dai Zeyan Zhuang Jinya Yao Zixuan Wu Shixuan Wang Fan Xia Jian Zhou Xiaoding Lou Zujin Zhao College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 510640China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074China

Robust photosensitizers with strong red/NIR fluorescence, efficient reactive oxygen species(ROS) generation and high photostability are highly desired for photodynamic therapy(PDT). Herein, three novel red conjugated polyelectrolytes(CPEs) with tetraphenylethene and 2,1,3-benzothiadiazole on the main chains and triphenylphosphonium on the side chains are *** CPEs display apparent aggregation-induced emission feature and high fluorescence quantum yields in the aggregated state. They can target lysosome in He La cells for fluorescence bioimaging. By virtue of the good retention effect and high photostability, these CPEs show ultralong-term tracing performance of subcutaneous tumors, and the tumor site can still be visualized for 20 days after injection. Owing to their good biocompatibility and strong ROS generation ability, the image-guided PDT based on these CPEs can effectively inhibit the growth of subcutaneous tumor and significantly prolong the survival of tumor bearing mice. The H&E and IHC staining reveal that the PDT of these CPEs depress the proliferation of tumor cells, and promote apoptosis and necrosis process. These new CPEs may be employed both as fluorescent probes for in vitro and in vivo long-term tracing and as photosensitizers for image-guided PDT of tumors.

关键词： conjugated polyelectrolytes aggregation-induced emission long-term tracing fluorescence imaging photodynamic therapy

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