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Selection of candidates for surgery as local therapy among early-stage small cell lung cancer patients: a population-based analysis

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Cancer Communications 2018年第1期38卷 63-73页

作者： Kaiqi Jin Kaixuan Zhang Feng Zhou Jie Dai Peng Zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityNo.507 Zhengmin RoadShanghai 200433P.R.China

Background:Surgery and radiotherapy are considered local therapies for small cell lung cancer(SCLC).The present study aimed to select candidates for surgery as local therapy among patients with stage I or II SCLC,based on the eighth edition of the TNM classification for lung ***:Patients diagnosed with SCLC between 2004 and 2013 were selected from the Surveillance,Epidemiology,And End Results *** TNM stage of SCLC in these patients was re-classified according to the eighth edition of the TNM classification for lung *** with stage I or II SCLC were included in the present *** survival(OS)and lung cancer-specific survival(LCSS)were separately compared in the different TNM stages between patients who received surgery and radiotherapy as local *** analysis was applied to evaluate multi-ple factors associated with ***:Among the 2129 patients included in the present study,387(18.2%)received surgery,1032(48.5%)under-went radiotherapy as local therapy,154(7.2%)underwent surgery and radiotherapy,and 556(26.1%)did not undergo either surgery or *** patients with T1-2N0(tumor size≤50 mm without positive lymph nodes)dis-ease,patients who underwent surgery had higher 5-year OS and LCSS rates than patients who received radiotherapy(T1N0:46.0%vs.23.8%,Ptherapy(T3N0:16.2%vs.26.5%,P=0.085,and 28.7%vs.30.9%,P=0.372,respectively;T1-2N1:20.3%vs.29.0%,P=0.146,and 25.6%vs.35.5%,P=0.064,respectively).Conclusions:Based on the assumption that the overwhelming majority of stage I or II SCLC patients who underwent surgery or radiotherapy also received

关键词： Small cell lung cancer Surgery local therapy Radiotherapy

Immunotherapy combined with local therapy in the late-line treatment of repair-proficient(pMMR)/microsatellite stable(MSS) metastatic colorectal cancer

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Immunotherapy combined with local therapy in the late-line t...

Immunogenic hydrogel toolkit disturbing residual tumor “seeds” and pre-metastatic “soil” for inhibition of postoperative tumor recurrence and metastasis

浙江省免疫学会第十三次学术大会

作者： Yuwei Ding Shanshan Weng Ning Zhu Mi Mi Ziheng Xu Liping Zhong Ying Yuan Department of Medical Oncology (Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical Sciences)The Second Affiliated HospitalZhejiang University School of Medicine Department of Oncology Huzhou Central Hospital Cancer Center of Zhejiang University Binjiang Institute of Zhejiang University

Colorectal cancer(CRC) is one of the three most common malignancies in the world 1,most patients are diagnosed with metastatic colorectal cancer(mCRC) at the first *** late-line standard treatment for mCRC patients is regorafenib,fruquintinib,and Trifluridine-tipiracil(TAS-102).Although both progression-free survival(PFS) and overall survival(OS) were beneficial compared to placebo,efficacies were still *** recent years,with the discovery of immune checkpoints,immunotherapy has been in full *** and nivolumab±ipilimumab have been approved for mismatch repair defect(dMMR)/high microsatellite instability(MSI-H) mCRC ***,only about 5% of mCRC are with dMMR/MSI-H,and the remaining 95% of mCRC patients are mismatch repair proficient(pMMR)/microsatellite stable(MSS).KEYNOTE-016 phase Ⅱ clinical trial showed that the objective response rate(ORR) of dMMR/MSI-H mCRC patients was 40%,and the ORR of pMMR/MSS mCRC patients was *** to break through the resistance of immunotherapy in pMMR/MSS mCRC patients has become a research *** 2019,REGONIVO(Japan) study opened a new era in the immunotherapy of pMMR/MSS mCRC *** studies of fruquintinib combined with sintilimab,LEAP-005 study,and CAMILLA study all suggested the great potential of tyrosine kinase inhibitors(TKIs)combined immunotherapy in pMMR/MSS mCRC ***,the REGONIVO study(North America),REGONIVO plus study,REGOTORI study,and Regomune study were unable to reproduce the satisfying ORR of REGONIVO(Japan),and the efficacy was *** ORRof these studies ranged from 7% to 27%,the disease control rate(DCR)was 39% to 80% and the median OS(mOS) was about 7.5 to 15.5 *** analyses of the REGONIVO(North America) study and REGONIVO plus study further showed almost no remission in pMMR/MSS mCRC patients with liver metastases,who were unable to respond to *** suggests that for pMMR/MSS mCRC patients with local metastasis espe

关键词： Immunotherapy local therapy Repair-proficient(pMMR)/microsatellite stable(MSS) Colorectal cancer

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3383-3397页

作者： Minglu Zhou Qingting Zuo Yuan Huang Lian Li Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Tumor recurrence and metastasis is the leading cause of mortality for postoperative breast cancer patients. However, chemotherapy intervention after surgery is often unsatisfactory, because residual microtumors are difficult to target and require frequent administration. Here, an all-in-one and oncefor-all drug depot based on in situ-formed hydrogel was applied to fit the irregular surgical trauma, and enable direct contact with residual tumors and sustained drug release. Our immunological analysis after resection of orthotopic breast tumor revealed that postsurgical activation of CXCR4-CXCL12 signal exacerbated the immunosuppression and correlated with adaptive upregulation of PD-L1 in recurrent tumors. Thus, a multifunctional hydrogel toolkit was developed integrating strategies of CXCR4 inhibition,immunogenicity activation and PD-L1 blockade. Our results showed that the hydrogel toolkit not only exerted local effect on inhibiting residual tumor cell “seeds” but also resulted in abscopal effect on disturbing pre-metastatic “soil”. Furthermore, vaccine-like effect and durable antitumor memory were generated, which resisted a secondary tumor rechallenge in 100% cured mice. Strikingly, one single dose of such modality was able to eradicate recurrent tumors, completely prevent pulmonary metastasis and minimize off-target toxicity, thus providing an effective option for postoperative intervention.

关键词： Hydrogel Postoperative treatment Tumor recurrence Pre-metastatic niche CXCR4 inhibition Immunotherapy local therapy Immunogenic cell death

Role of stereotactic body radiotherapy for oligometastasis from colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4220-4229页

作者： Atsuya Takeda Naoko Sanuki Etsuo Kunieda Radiation Oncology Center Ofuna Chuo HospitalKanagawa 247-0056Japan Department of Radiation Oncology Tokai UniversityKanagawa 259-1193Japan

Systemic chemotherapy has enabled prolongation of survival in patients with stage IV colorectal cancer. This has subsequently increased the relative significance of local therapy for patients with oligometastases because they can be cured by removal of oligometastatic lesions. One of the most frequently reported tumor histologies for oligometastases is colorectal cancer. Resection is the standard therapy in most settings of oligometastases. Recently, studies have shown that stereotactic body radiotherapy (SBRT) may become a treatment option that provides high local control with minimal morbidity. Two-year local control rates following SBRT for hepatic and pulmonary oligometastases are almost over 80% and are even higher for patients treated with high-dose regimens. The indications of SBRT for other metastatic sites or conditions include isolated lymph nodes, spinal and adrenal metastasis, and post-surgical pelvic recurrence. Many retrospective studies have indicated that SBRT for various lesions results in good outcomes with low morbidity, both in the curative and palliative setting. However, few reports with a high level of evidence have indicated the efficacy of SBRT compared to standard therapy. Hereafter, the optimal indication of SBRT needs to be prospectively investigated to obtain convincing evidence.

关键词： Oligometastasis Colorectal cancer Radiation therapy Stereotactic ablation body radiation therapy local therapy

Advancing dental implants:Bioactive and therapeutic modifications of zirconia

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Bioactive Materials 2022年第7期7卷 161-178页

作者： Divya Chopra Anjana Jayasree Tianqi Guo Karan Gulati Saso Ivanovski The University of Queensland School of DentistryHerston QLD4006Australia

Zirconium-based implants have gained popularity in the dental implant field owing to their corrosion resistance and biocompatibility,attributed to the formation of a native zirconia(ZrO_(2))***,enhanced bioactivity and local therapy from such implants are desirable to enable the earlier establishment and improved long-term maintenance of implant integration,especially in compromised patient *** a result,surface modification of zirconium-based implants have been performed using various physical,chemical and biological techniques at the macro-,micro-,and *** this extensive review,we discuss and detail the development of Zr implants covering the spectrum from past and present advancements to future perspectives,arriving at the next generation of highly bioactive and therapeutic nano-engineered Zr-based *** review provides in-depth knowledge of the bioactive/therapeutic value of surface modification of Zr implants in dental implant applications focusing on clinical translation.

关键词： Zirconium Zirconia Implants Surface modification Osseointegration Bioactivity local therapy

Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats

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Asian Journal of Andrology 2017年第1期19卷 43-46页

作者： Fatih Mete Huseyin Tarhan Orcun Celik Ilker Akarken Kamil Vural Rahmi Gokhan Ekin Isil Aydemir Yusuf Ozlem Ilbey Kanuni Sultan Suleyman Education and Research Hospital Pediatric Clinic 34150 Istanbul Turkey Tepecik Education and Research Hospital Urology Clinic 35170 IzmirTurkey Celal Bayar University Faculty of Medicine Department of Pharmacology45180 Manisa Turkey Celal Bayar University Faculty of Medicine Department of Histology and Embryology 45180 Manisa Turkey.

We compare the efficacy of intratesticular ozone therapy with intraperitoneal ozone therapy in an experimental rat model. For this purpose, 24 rats were divided into four groups including sham-operated, torsion/detorsion, torsion/detorsion plus intraperitoneal ozone （O-IP）, and torsion/detorsion plus intratesticular ozone （O-IT）. The O-IP ozone group received a 4 mg kg-1 intraperitoneal injection of ozone, and the O-IT group received the same injection epididymally. At 4 h after detorsion, the rats were sacrificed and orchiectomy materials were assessed histopathologically. Spermatogenesis in the seminiferous tubules and damage to the Sertoli cells were histopathologically evaluated in the testes using the Johnsen scoring system, i-NOS and e-NOS activities in the testis tissue were also evaluated. Torsion-detorsion caused a decreased Johnsen score and increased apoptosis of spermatogonial and Sertoli cells. Ozone injection prevented increases in Johnsen score and i-NOS level, e-NOS level of the O-IP group was significantly lower than that of the O-IP group, and i-NOS level of the O-IT group was significantly lower than that of the O-IP group. local ozone therapy is more effective than systemic ozone therapy at improving IRI-related testicular torsion. Our study is the first to show that the efficacy of intratesticular implementation of ozone therapy is higher than that of intraperitoneal ozone therapy.

关键词： local therapy ozone rat model testis torsion

Long-term control of melanoma brain metastases with co-occurring intracranial infection and involuntary drug reduction during COVID- 19 pandemic: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2373-2379页

作者： Yang Wang Bin Lian Chuan-Liang Cui Department of Renal Cancer and Melanoma Peking University Cancer Hospital&InstituteBeijing 100142China

BACKGROUND Melanoma brain metastasis is a common cause of death in melanoma patients andis associated with a poor prognosis. There are relatively few reports onintracranial infections after brain metastasis *** SUMMARY Here we report a case of melanoma brain metastases in a patient harboring aBRAF V600E mutation, who experienced intracranial tumor progression despiteprevious combined treatment with a programmed death (PD)-1 inhibitor, axitinib,and vemurafenib. She repeatedly underwent local therapy, including stereotacticradiosurgery and intracranial surgery, and developed central nervous systeminfection. Treatment with vemurafenib combined with cobimetinib resulted in anintracranial progression-free survival of 10 mo. During the coronavirus disease2019 (COVID-19) pandemic, the patient did not visit the hospital for regularvemurafenib treatment, and experienced intracranial progression afterinvoluntary drug reduction for 1 mo. The patient subsequently received varioussystemic treatments including vemurafenib, PD-1 inhibitor, and chemotherapy,with an overall survival of 29 mo as of September *** We report the first case of melanoma brain metastases with co-occurringintracranial infection and unintended drug reduction during the COVID-19outbreak. Long-term control of the intracranial lesions was achieved withsystemic and local therapies.

关键词： Melanoma Intracranial infection Brain metastases COVID-19 local therapy Case report

Radiotherapy,photodynamic therapy,and cryoablation‐induced abscopal effect:Challenges and future prospects

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Cancer Innovation 2023年第5期2卷 323-345页

作者： Sadik Ali Mohammad Arshadul Hak Sunil V.Pogu Aravind K.Rengan Indian Institute of Technology Hyderabad KandiSangareddyTelanganaIndia

local therapy modalities such as radiation therapy,photodynamic therapy,photothermal therapy,and cryoablation have been used to treat localized tumors for *** discovery of the abscopal effect causes a paradigm shift where local therapy also causes systemic effects and leads to the remission of nonirradiated *** abscopal effect of radiation therapy,alone or in combination with other treatments,has been extensively studied over the last six ***,the results are unsatisfactory in producing robust,reproducible,and long‐lasting systemic *** immunotherapy and radiation therapy are promising in producing the abscopal effect,the abscopal effect's mechanism is still unclear,owing to various factors such as irradiation type and dose and cancer *** article reviews the research progress,clinical and preclinical evidence of the abscopal effect by various local therapies alone and in combination with chemotherapy and immunotherapy,case reports,and the current challenges in producing the abscopal effect by various local therapies,focusing on radiotherapy,photodynamic therapy,cryoablation,and the prospects for obtaining a robust,reproducible,and long‐lasting abscopal effect.

关键词： abscopal effect local therapy radiotherapy photodynamic therapy cryoablation immunotherapy cancer

Surgical vs percutaneous radiofrequency ablation for hepatocellular carcinoma in dangerous locations

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World Journal of Gastroenterology 2011年第1期17卷 123-129页

作者： Ji-Wei Huang Roberto Hernandez-Alejandro Kristopher P Croome Lu-Nan Yan Hong Wu Zhe-Yu Chen Pankaj Prasoon Yong Zeng Department of Hepato-Biliary-Pancreatic Surgery Division of Liver Transplantation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Surgery University of Western Ontario Hepatobiliary and Liver Transplant Surgery London Health Sciences Centre London Ontario N6A 4S2 Canada

AIM:To compare the long-term outcome of percutaneous vs surgical radiofrequency ablation(RFA) for hepatocellular carcinoma(HCC) in dangerous ***:One hundred and sixty-two patients with HCC in dangerous locations treated with percutaneous or surgical RFA were enrolled in this *** patients were divided into percutaneous RFA group and surgical RFA *** the patients were regularly followed up for a long time,their curative rate,hospital stay time,postoperative complications and 5-year local tumor progression were compared and ***:No significant difference was observed in curative rate between the two groups(91.3% vs 96.8%,P = 0.841).The hospital stay time was longer and more analgesics were required while the incidence of bile duct injury and RFA-related hemorrhage was lower in surgical RFA group than in percutaneous RFA group(P local progression rate of HCC in dangerous locations was significantly lower in surgical RFA group than in percutaneous RFA group(P = 0.05).The relative risk of local tumor progression was 14.315 in percutaneous RFA ***:The incidence of severe postoperative complications and local tumor progression is lower after surgical RFA than after percutaneous RFA.

关键词： Hepatocellular carcinoma Radiofrequency ablation Liver cirrhosis Recurrence local therapy