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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor Cortex during Movement Preparation

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Neuroscience Bulletin 2019年第5期35卷 826-840页

作者： Hongji Sun Xuan Ma Liya Tang Jiuqi Han Yuwei Zhao Xuejiao Xu Lubin Wang Peng Zhang Luyao Chen Jin Zhou Changyong Wang School of Life Science and Technology Harbin Institute of Technology 92 West Dazhi Street Nan Gang District Harbin 150080 China Department of Neural Engineering and Biological Interdisciplinary Studies Institute of Military Cognition and Brain Sciences Academy of Military Medical Sciences 27 Taiping Rd Beijing 100850 China Department of Neurology Chinese PLA General Hospital Beijing 100853 China

Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta oscillations in implicit timing tasks are lacking. In this study, we set up an implicit motor timing task and found a modulation pattern of beta oscillations with temporal perception during movement preparation. We trained two macaques in a repetitive visually-guided reach-to-grasp task with different holding intervals. Spikes and local field potentials were recorded from microelectrode arrays in the primary motor cortex, primary somatosensory cortex, and posterior parietal cortex. We analyzed the association between beta oscillations and temporal interval in fixedduration experiments(500 ms as the Short Group and1500 ms as the Long Group) and random-duration experiments(500 ms to 1500 ms). The results showed that the peak beta frequencies in both experiments ranged from15 Hz to 25 Hz. The beta power was higher during the hold period than the movement(reach and grasp) ***, in the fixed-duration experiments, the mean poweras well as the maximum rate of change of beta power in the first 300 ms were higher in the Short Group than in the Long Group when aligned with the Center Hit event. In contrast, in the random-duration experiments, the corresponding values showed no statistical differences among groups. The peak latency of beta power was shorter in the Short Group than in the Long Group in the fixed-duration experiments, while no consistent modulation pattern was found in the random-duration experiments. These results indicate that beta oscillations can modulate with temporal interval in their power mode. The synchronization period of beta power could reflect the cognitive set maintaining working memory of the temporal structure and attention.

关键词： Macaque Primary motor cortex Primary somatosensory cortex Posterior parietal cortex Temporal perception local field potentials

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Changes of default mode network in differential anesthesia level rats

Changes of default mode network in differential anesthesia l...

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中国神经科学学会第十二届全国学术会议

作者： Fengru Guo Tianjiao Zhang Bochao Niu Daqing Guo Dezhong Yao Yang Xia Key Laboratory for Neuro Information of Ministry of Education Center for Information in Medicine University of Electronic Science and Technology of China

Objective Anesthetic such as isoflurane leads to loss of consciousness in human and animals. The proper function of neural circuitries and networks is essential to maintain meaningful information exchange and integration, and thus to support normal brain function. Anesthesia has been shown to profoundly alter neural circuit function. Nevertheless, neuronal mechanism underlying remains poorly understood. Researches on human brains have shown that anesthesia is characterized by spatially spectral and coherence signatures that also been implicated in the global impairment of cortical communication. Functional magnetic resonance imaging（f MRI） has shown that the rodent brain has a like default mode network（DMN） activity with human brain. In this work, our purpose is to focus whether anesthesia has similar effects on DMN in rats. Methods Adult Sprague-Dawley rats were chronically implanted with epidural and coaxial depth electrodes to record local field potentials（LFPs） in brain areas of DMN. The relationship between DMN activity and anesthesia concentration was tested under three anesthetic states in rats: 0.75%, 1.00%, and 1.50% doses of isoflurane and evaluate the effects of isoflurane anesthesia on DMN by coherence analysis. Results The results showed a significant reduction of coherence signatures following dose of anesthesia increased. At 1.50% dose of isoflurane, DMN connectivity decreased significantly in the band of 1-55 Hz, whereas DMN connectivity increased in the band of 1-4 Hz. Conclusion Our analysis suggest that dynamic DMN are linked to different frequencies of neural activity and isoflurane anesthesia may significant impact on this relationship.

关键词： default mode network(DMN) anesthesia steady–state visually evoked potentials(SSVEPs) isoflurane local field potentials

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Research of Electrophysiological DMN Based on Rapid Eye Movement Sleep Deprivation Rats Model

Research of Electrophysiological DMN Based on Rapid Eye Move...

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中国神经科学学会第十二届全国学术会议

作者： Tianjiao Zhang Yanran Wang Fengru Guo Daqing Guo Yang Xia Dezhong Yao Key Laboratory for Neuro Information of Ministry of Education Center for Information in Medicine University of Electronic Science and Technology of China

Objective Experimental sleep deprivation（SD）, both in humans and in animal models, has been widely employed to unveil various aspects of sleep function as well as to study the effects of sleep loss on subsequent brain function. SD can also provide a basis for understanding the network mechanism of sleep disorders. Default mode network （DMN） is posited to play a fundamental role in maintaining the resting state functional brain activity, such as sleep, and involves a variety of cognitive process and neuropsychological diseases. But effect of SD on DMN remains poorly understood. Here, we explore DMN changes after rapid eye movement sleep（REM）-selective SD in adult rats. Methods: Under anesthesia, fifteen electrodes were implemented into the DMN regions of rat defined by f MRI for recording local field potentials（LFPs） both before and after REM-selective SD. The changes of sleep phase and electrophysiological DMN were evaluated by the PSD analysis and Phase locking value（PLV） methods. Results（1） Both the cumulative time and occurrence number of REM sleep were increased significantly after REM-selective SD.（2） After REM-selective SD, REM sleep power spectrum increased significantly in γ band.（3） During REM sleep after REMselective SD, the network connectivity and small world properties of DMN decreased in δ band, whereas increased in θ band. Conclusion Our results suggest that the changes of sleep phase after REM-selective SD might be related to the variation of DMN connectivity. And increased REM sleep phase might imply a compensation mechanism in mammalian brain.

关键词： sleep deprivation default mode network rapid eye movement sleep power spectrum local field potentials

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额-顶-丘脑底核电生理活动解码帕金森病患者的运动状态

额-顶-丘脑底核电生理活动解码帕金森病患者的运动状态

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第十八届中国医师协会神经外科医师年会

作者：张泉解虎涛赵宝田尹子霄刘钰晔刘德峰杨岸超孟凡刚姜胤张建国首都医科大学附属北京天坛医院北京市神经外科研究所

目的帕金森病(PD)患者存在多种运动障碍,包括站立困难、步态启动和冻结步态等。这些异常与皮层-丘脑底核功能障碍相关。我们旨在揭示帕金森病患者在不同运动状态下的皮层-丘脑底核活动特征。方法在18名自由行走的帕金森病患者中,记录了... 详细信息

目的帕金森病(PD)患者存在多种运动障碍,包括站立困难、步态启动和冻结步态等。这些异常与皮层-丘脑底核功能障碍相关。我们旨在揭示帕金森病患者在不同运动状态下的皮层-丘脑底核活动特征。方法在18名自由行走的帕金森病患者中,记录了在药物"关"(Moff)和"开"(Mon)状态下,顶上小叶(SPL)、初级运动皮层(M1)、运动前区皮层(PMC)以及双侧丘脑底核(STN)的电位活动,涵盖患者在坐、站立、行走、双任务行走及冻结步态时的状态。通过频段能量对不同的运动状态活动进行比较,并使用机器学习分类器区分这些运动状态。结果顶上小叶(SPL)的beta功率在从站立到行走的过程中表现出特异性抑制,并与步行速度呈负相关;初级运动皮层(M1)的beta功率反映了僵硬程度,并且在药物作用下有所逆转。XGBoost算法以可接受的准确率对五种运动状态进行分类(Moff状态下为68.77%,Mon状态下为60.58%)。在Moff和Mon状态下,SPL的beta功率在特征重要性排名中均位居首位。结论顶上小叶(SPL)的beta功率在步态状态分类中起着重要作用,可能成为步行速度的生理生物标志物,这将有助于自适应深部脑刺激(DBS)的发展。

关键词： local field potentials machine learning motor decoding parietal lobule Parkinson's disease

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