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Rapidly separable bubble microneedle patch for effective local anesthesia

Nano Research 2022年第9期15卷 8336-8344页

作者： Yuan Yang Huaqing Chu Yan Zhang Lingling Xu Ruizeng Luo Hui Zheng Tailang Yin Zhou Li CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China Reproductive Medicine Center Renmin Hospital of Wuhan UniversityWuhan 430060China School of Chemistry and Chemical Engineering Center on Nanoenergy ResearchGuangxi UniversityNanning 530004China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

In cutaneous cosmetology surgery,local injection or coated anesthetics are generally used to provide analgesia at the treatment site to achieve painless *** to the barrier of corneum,topical cream may cause uncertain dosage and delayed *** injection has problems such as pain,infection,and ***,it is necessary to develop a painless and rapid administration method for local ***,a lidocaine/hyaluronic acid bubble microneedle patch(Lido/HA bMNP)was prepared for rapid drug delivery and efficient *** bubble structure between microneedles(MNs)and the backing layer allowed the MNs to efficiently penetrate into the skin and remove from the backing layer under shear force to rapidly complete the *** were quickly released with the dissolution of HA within 15 s,which immediately played an analgesic effect and lasted for 1 ***/HA bMNP could deliver precise doses to the skin in an extremely short time,which had the advantages of convenient operation,high biosafety,rapid onset of analgesia,and reasonable pain relief *** patch provided an alternative way for local anesthesia and it was a promising transdermal drug delivery method for the realization of high quality and efficiency“painless medical beauty”.

关键词： separable bubble microneedle patch hyaluronic acid rapid drug delivery local anesthesia cutaneous cosmetology surgery

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Lidocaine hydrochloride loaded isomaltulose microneedles for efficient local anesthesia of the skin

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Chinese Chemical Letters 2024年第4期35卷 298-302页

作者： Xuebing Jiang Siyi Wang Li Zhang Xian Jiang Maling Gou State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China Huahang Microcreate Technology Co. Ltd.Chengdu 610042China Department of Dermatology West China HospitalSichuan UniversityChengdu 610041China

Lidocaine hydrochloride(LIDH) as an anesthetic is widely used in local anesthesia. Dissolving microneedles(MNs) have great application value in the field of skin anesthesia. However, the limited drug-loading of dissolving MNs is an existing challenge that affects clinical use. In this study, we have screened isomaltulose(ISO) as the proper matrix material for the MNs by using molecular dynamics(MD) simulation. Our findings indicate that ISO has good compatibility with LIDH, and the LIDH-loaded ISO MNs(LI-MNs) have high drug-loading capacity. The drug-loading capacity of LI-MNs could reach 80%, and it could effectively puncture the skin. In addition, the preparation method of customized LI-MNs was established based on three-dimensional(3D) printing technology. It was shown that the administration time of LI-MNs could be controlled within 3 min. Also, the LI-MNs were able to provide the local anesthetic efficacy within2 min and sustained for more than 2 h. Significantly, LI-MNs had more efficient drug efficacy compared to the topical creams and the majority of existing LIDH-loaded dissolving MNs. They even provided a longer duration of action than the injections. Overall, the LI-MNs with high drug-loading have a promising application prospect.

关键词： Microneedles local anesthesia Lidocaine hydrochloride Isomaltulose Transdermal delivery

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General anesthesia versus local anesthesia for penetrating keratoplasty: a prospective study

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 278-282页

作者： Xu Wang Guang-Fu Dang Ying-Mei Li Wei-Fan Li Xin-Yi Wu Department of Ophthalmology Qianfoshan HospitalMedical School of Shandong University Department of Ophthalmology Jinan No.2 Hospital Department of Anesthesiology Jinan No.2 Hospital Department of Ophthalmology Qilu Hospital Medical School of Shandong University

AIM:To examine which anesthesia general or local is more effective for penetrating keratoplasty(PKP).METHODS:Patients with indications for PKP(n=141)were enrolled in a prospective study and randomly divided into general anesthesia group(group A,70 eyes)and local anesthesia group(group B,71 eyes).Patients received optical PKP(group A1,30 eyes;group B1,30eyes)or therapeutic PKP(group A2,40 eyes;group B2,41 eyes).Measurement of anterior chamber treatment time(T)for PKP patients and the ratio(R)of the area of the pupils to that of recipient graft region.T and R values,as well as perioperative and postoperative complications,were compared between groups A and B using t-test orχ***:Patients were followed for 2wk after PKP.T was(13.45±8.64)min for group A and(7.36±5.24)min for group B,a statistically significant difference(Panesthesia,pupils remaine stable during PKP and perioperative complications are *** anesthesia gives more time to treat pathological changes in the anterior chamber and treatment success rate is higher.

关键词： penetrating keratoplasty general anesthesia local anesthesia

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Ureteroscopy during pregnancy under local anesthesia and light sedation:Technique and video

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Current Urology 2023年第3期17卷 219-220页

作者： Patrick Juliebø-Jones Christian Beisland Peder Gjengstø Rachel Maheswaran Øyvind Ulvik Department of Urology Haukeland University Hospital5021BergenNorway Department of Clinical Medicine University of BergenBergenNorway

Ureteroscopy during pregnancy has become increasingly recognized as a safe *** it under local anesthesia and light sedation reduces the risks associated with general or regional anesthesia,such as difficult airway scenarios,hypothermia,and *** addition,this approach reduces the total amount of fetal exposure to medications and anesthetic *** ureteroscopy in this manner requires a number of adjustments and modifications to the standard *** article provides a summary in a step-by-step format,as well as an accompanying video demonstration.

关键词： Endourology Ureteroscopy Urolithiasis Lithotripsy Pregnancy local anesthesia Light sedation

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Influence of local anesthesia on the outcomes of non-surgical periodontal treatment

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Chinese Medical Journal 2020年第16期133卷 1908-1914页

作者： Shu-Wen Shi Jian Jiao Li Zhang Rui-Fang Lu Huan-Xin Meng Zhan-Qiang Cao Dong Shi Yi Song Department of Periodontology Peking University School and Hospital of StomatologyBeijing 100081China Department of Periodontology Peking University Hospital of Stomatology First Clinic DivisionBeijing 100034China Information Center Peking University School and Hospital of StomatologyBeijing 100081China Institute of Child and Adolescent Health School of Public HealthPeking UniversityBeijing 100191China Department of Clinical Sciences Social Medicine and Global HealthLund UniversityMalmö20213Sweden

Background:There is limited evidence of the effects of local anesthesia(LA)on outcomes of non-surgical periodontal treatment(NSPT),in particular among the *** retrospective cohort study aimed to evaluate the effects of LA on short-term treatment outcomes of NSPT and to determine under what circumstances LA should be prescribed to improve these ***:Data from periodontal examinations of 3980 patients were *** data were from 3-month re-evaluation records of an electronic periodontal charting record system in the Department of Periodontology of Peking University School and Hospital of Stomatology from June 2008 to January *** analyses included changes in probing depth(PD)and the Mazza bleeding index(BI).Two-level(patient and tooth)logistic regression models and three-level(patient,tooth,and site)linear regression models were constructed to analyze the influence of LA on PD for all teeth/sites and teeth/sites with an initial PD≥5 *** in PD and BI at sites under LA using the initial PD were also ***:A significantly higher mean decrease in PD after NSPT was found in the LA group than in the no local anesthesia(NLA)group(0.98 vs.0.54 mm,t=24.12,P1 and BI>2)for all teeth(16.7%vs.13.8%,t=3.75,P<0.001;34.7%vs.28.1%,t=6.73,P<0.001)and PD for teeth with PD≥5mm(32.3%vs.17.3%,t=28.48,P<0.001).The difference in PD between the LA and NLA groups increased as the initial PD *** difference between the two groups was 0.12 to 0.22 mm for sites with a baseline PD<7 mm;however,it increased to 0.41 to 1.37 mm for sites with a baseline PD≥7 ***:LA improved the decrease in PD after *** debridement at sites with initial PD≥7 mm should be performed under routine LA.

关键词： local anesthesia Periodontitis Periodontal debridement

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Cure of Varicocele under local anesthesia: Impact on Sperm Parameters

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Open Journal of Urology 2024年第10期14卷 507-513页

作者： Babacar Sine Arsen Ngoie Mudiangombe Ndeye Aissatou Bagayogo Amath Thiam Omar Cissokho Moustaf Cheikh Ahmed Abdoulaye Ndiath Ibrahima Cisse Babacar Diao Khassim Ndoye Alain Urology Andrology Department of Military Hospital of Ouakam Dakar Senegal Urology Andrology Department of the Aristide Le Dantec Hospital Dakar Senegal

Introduction: Varicocele is one of the most frequent causes of infertility. There are several therapeutic modalities, namely surgery (open and laparoscopic) and conventional radiology. The aim of our study was to evaluate the impact of a varicocele cure under local anaesthesia on spermogram quality. Material and Methods: We conducted a retrospective descriptive study from 1 January 2022 to 31 December 2023 in the urology department of the Hôpital Militaire de Ouakam (HMO). The parameters studied were age, reasons for consultation, time to urology consultation, grade of varicocele, Doppler ultrasound and spermogram data before treatment and 3 months after treatment. Treatment consisted of bilateral subinguinal varicocelectomy under local anaesthetic. Data were entered and analysed using Excel software version 2021. Results: We studied 41 patients. The mean age of the patients was 35.3 ± 6.9 years, with extremes of 22 and 50 years. Thirty-eight of our patients (88.37%) were married. The most frequent reason for consultation was primary infertility (72.09%). 28 patients (68.3%) had a bilateral varicocele on ultrasound. Varicocele was associated with bilateral testicular hypotrophy in 13 patients (31.7%) and unilateral left testicular hypotrophy in 11 patients (26.8%). All patients underwent subinguinal varicocelectomy under local anaesthetic. Mean follow-up was 4.5 months. A clear statistically significant improvement was noted in sperm motility and concentration in postoperative spermograms, with normalisation of the spermogram in 15 (36.5%) of patients. Conclusion: The impact of varicocele on sperm parameters has been clearly established. There are various therapeutic methods for curing varicocele, including varicocelectomy under local anaesthetic, which, in addition to its undeniable economic advantages, can significantly improve sperm parameters in patients with varicocele and prevent their deterioration over time.

关键词： Varicocele local anesthesia Spermogram

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Bloodless Outpatient Surgical Treatment of Rectocele and Cystocele under local anesthesia

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Open Journal of Obstetrics and Gynecology 2021年第5期11卷 569-577页

作者： Octacílio Figueirêdo Netto Priscila Garcia Figueirêdo Eduardo Garcia Figueirêdo Wildecir Barros Department of Gynecology and Obstetrics Londrina State University Londrina Brazil Endofemina Gynecologic Surgery and Laser Londrina Brazil *** Online Vaginal Surgery Course Londrina Brazil Brazilian College of Laser Sculpture Brasília Brazil Bella Forma Laser Brasília Brazil

Background: Surgical treatment of rectocele and cystocele is usually performed in a hospital setting under regional (spinal or epidural) or general anesthesia, and patients commonly have to stay in the hospital for at least one or two days. The possibility of performing the surgery under local anesthesia, as an outpatient procedure with minimal bleeding and pain, no surgical assistants, with immediate discharge and, most importantly, without compromising postoperative results, is appealing. To our knowledge, no studies have evaluated whether performing rectocele and/or cystocele rectocele repair under local infiltration anesthesia and without separation of the vaginal mucosa from the underlying fascia achieves these goals. Objective: The aim of this study is to describe a new surgical technique for outpatient treatment of cystocele and rectocele under local anesthesia, and our initial results. Materials and Methods: Forty women underwent outpatient surgical repair of rectocele and/or cystocele between April and September 2020 at the ambulatory procedure room of the authors’ clinics. The technique consists of a triangular-shaped CO2

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Inguinal Hernia Repair with local anesthesia in the Outpatient—10 Year Experience

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International Journal of Clinical Medicine 2014年第12期5卷 644-649页

作者： Flavio Antonio de Sa Ribeiro Baltazar de Araujo Fernandes Joao Pedro de Araujo Simoes Correa Surgery of UNIFESO TeresopolisBrazil Hospital Federal de Bonsucesso Rio de JaneiroBrazil General Surgery Service Hospital Geral de BonsucessoRio de JaneiroBrazil

Objective: To demonstrate the feasibility of inguinal hernia repair with local anesthesia in an out-patient regime, with safety, efficacy and short learning curve. Methods: We prospectively evaluated 1186 patients undergoing inguinal hernia repair under local anesthesia on an outpatient basis between November 2004 and March 2014. Of the total number of hernias surgically treated in this period, 755 were operated on the right, 394 on the left and 37 bilateral. We used clinical, surgical and psychosocial criteria for inclusion in the procedure. The parameters for exclusion were complex, irreducible or recurrent hernia, obesity (BMI greater than 30 kg/m2), patient’s refusal and psychiatric disorder. All patients underwent elective surgery and were analyzed regarding surgical outcome, complications and hospital stay. Results: All operations were completed successfully. In no case there was a need to change the anesthetic method. Surgical time was similar to that conducted with other methods of anesthesia and there were no cases of adverse effects of local anesthetics. Intra-operative complications amounted to approximately 2.64%. There was no need for hospital admissions greater than 24 hours. Conclusion: The procedure is feasible and causes no perioperative significant pain, is safe, can be performed by residents under supervision, has satisfactory patient acceptance and complications similar to those observed in a conventional herniorrhaphy, allowing lower time and cost of hospitalization and faster access to treatment.

关键词： Inguinal Hernia/Surgery local anesthesia Ambulatory Surgical Procedures

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Management of Square Carcinoma of the Lower Lip Using Camille-Bernard Flap under local anesthesia: When Constraints Dictate Our Attitude

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Open Journal of Stomatology 2024年第4期14卷 191-197页

作者： Silly Toure Mouhamadou Makhtar Ndiaye Abibou Ndiaye Mame Sanou Diouf Birame Loum Baye Karim Diallo Department of Maxillofacial Surgery and Stomatology CHU Aristide Le Dantec of Dakar Dakar Senegal ENT Department Fann University Hospital Dakar Senegal

Introduction: Squamous cell carcinomas of the lip essentially pose a therapeutic management problem. In the West, their treatment is done under general anesthesia and follows the classic rules of oncology. In our context of exercise, we sometimes have a different attitude dictated by various constraints. Observation: 55-year-old patient with no notable history, seen in consultation for a very large ulcerative-budding lesion on the right 2/3 of the lower lip with mucocutaneous involvement without lymph node findings found on examination. Faced with this suspicious lesion and the patient’s financial difficulties, we decided to operate under local anesthesia to remove this tumor. The oncological excision was followed by immediate plasty using a Camille-Bernard flap with a good immediate aesthetic and functional result and postoperative day 7. The patient was unable to take his surgical specimen to anatomy-pathology and was lost to follow-up due to lack of financial resources. On anatomo-pathological analysis of the surgical specimen, the margins were healthy with confirmation of squamous cell carcinoma (anapathological reading made for scientific interest). Discussion: The particular mentality of certain patients and their difficult financial conditions push us to have an unconventional therapeutic attitude in oncology, but which nevertheless makes it possible to resolve certain problems that we often face. local anesthesia is possible and realistic in cases like ours and the results can be acceptable and life-saving.

关键词： Squamous Cell Carcinoma Lower Lip Camille Bernard Flap local anesthesia

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Feasibility analysis of rapid right ventricular pacing in thoracic endovascular aortic repair under local anesthesia

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South China Journal of Cardiology 2014年第1期15卷 22-26页

作者：黄文晖罗建方刘媛薛凌何鹏程 Guangdong General Hospital Guangdong Academy of Medical SciencesGuangdong Provincial Cardiovascular Institute

Background Rapid right ventricular pacing is one of the methods for counteracting the ＂wind sock＂ effect in the thoracic endovascular aortic repair （TEVAR）. Most of the doctors are to complete this operation under general anesthesia. Now, our operation has been performed under local anesthesia. No related reports were found as to whether can the patient tolerate rapid fight ventficular pacing under local anesthesia. Methods From 2009 January to 2010 January, in our hospital all the DeBakey llI aortic dissection patients who underwent TEVAR were randomly divided into general anesthesia group （n = 50） and local anesthesia group （n = 51）. All the data were compared between two groups including the hemodynamic indexes, the graft positioning accuracy, rapid pacing duration, operation time, intraoperative discomfort and postoperative neurological understanding function changes and the complications. Results The success rate were 100% in the two groups. The duration of rapid pacing, operation time, the accuracy of graft localization and the intraoperative discomfort scores of Numerical Pain Rating Scale showed no significant difference between the two groups （P 〉 0.05）. There were no rapid fight ventricular pacing-related complications in the two groups. Conclusion During thoracic endovascular aortic repair procedure, rapid fight ventricular pacing under local anesthesia is safe and feasible. Thus it is worthy to be popularized in clinical practice.

关键词： thoracic aorta endovascular repair local anesthesia rapid fight ventricular pacing

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