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Non-invasive model for predicting esophageal varices based on liver and spleen volume

World Journal of Clinical Cases 2022年第32期10卷 11743-11752页

作者： Long-Bao Yang Gang Zhao Xin-Xing Tantai Cai-Lan Xiao Si-Wen Qin Lei Dong Dan-Yan Chang Yuan Jia Hong Li Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Medicine Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Upper endoscopy is the gold standard for predicting esophageal varices in *** and consensus suggest that patients with liver cirrhosis should undergo periodic upper endoscopy,most patients undergo their first upper endoscopy when esophageal variceal ***,it is important to develop a non-invasive model to early diagnose esophageal *** To develop a non-invasive predictive model for esophageal varices based on liver and spleen volume in viral cirrhosis *** We conducted a cross-sectional study based on viral cirrhosis crowd in the Second Affiliated Hospital of Xi'an Jiaotong *** collecting the basic information and clinical data of the participants,we derived the independent risk factors and established the prediction model of esophageal *** established model was compared with other *** under the receiver operating characteristic curve,calibration plot and decision curve analysis were used to test the discriminating ability,calibration ability and clinical practicability in both the internal and external *** The portal vein diameter,the liver and spleen volume,and volume change rate were the independent risk factors of esophageal *** successfully used the factors to establish the predictive model[area under the curve(AUC)0.87,95%CI:0.80-0.95],which showed better predictive value than other *** model showed good discriminating ability,calibration ability and the clinical practicability in both modelling group and external validation *** The developed non-invasive predictive model can be used as an effective tool for predicting esophageal varices in viral cirrhosis patients.

关键词： Gastroscopy Esophageal varices liver volume Cirrhosis Non-invasive diagnostic model Spleen volume

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liver and spleen volume variations in patients with hepatic fibrosis

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World Journal of Gastroenterology 2009年第26期15卷 3298-3302页

作者： Peng Liu Peng LI Wen He Li-Qin Zhao Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

AIM： To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages. METHODS： Multidetector computed tomography （MDCT） scan was performed in 85 hepatic fibrosis patients. liver volume （LV） and spleen volume （SV） were measured. Fifteen healthy individuals served as a control group （SO）. The patients were divided into stage 1 （S1） group （n = 34）, stage 2 （S2） group （n = 25）, stage 3 （S3） group （n = 16）, and stage 4 （S4） group （n = 10） according to their histopathological stage of liver fibrosis. RESULTS： The LV and standard LV （SLV） had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups （LV： F = 0.245, P = 0.912; SLV： F = 1.902, P = 0.116）. The SV was gradually increased with the severity of fibrosis, and a statistically significant difference in SV was observed among the 5 groups （P 〈 0.01）. The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups （P 〈 0.01）.CONCLUSION： The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis. The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.

关键词： Hepatic fibrosis volume measurement liver volume Standard liver volume Spleen volume liver volume/spleen volume ratio Standard liver volume/spleen volume ratio

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Non-invasive prediction model for high-risk esophageal varices in the Chinese population

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World Journal of Gastroenterology 2020年第21期26卷 2839-2851页

作者： Long-Bao Yang Jing-Yuan Xu Xin-Xing Tantai Hong Li Cai-Lan Xiao Cai-Feng Yang Huan Zhang Lei Dong Gang Zhao Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND There are two types of esophageal varices(EVs):high-risk EVs(HEVs)and lowrisk EVs,and HEVs pose a greater threat to patient life than low-risk *** diagnosis of EVs is mainly conducted by gastroscopy,which can cause discomfort to patients,or by non-invasive prediction models.A number of noninvasive models for predicting EVs have been reported;however,those that are based on the formula for calculation of liver and spleen volume in HEVs have not been *** To establish a non-invasive prediction model based on the formula for liver and spleen volume for predicting HEVs in patients with viral *** Data from 86 EV patients with viral cirrhosis were *** liver and spleen volumes of the patients were determined by computed tomography,and their calculated liver and spleen volumes were calculated by standard *** imaging and biochemical data were *** impact of each parameter on HEVs was analyzed by univariate and multivariate analyses,the data from which were employed to establish a non-invasive prediction *** the established prediction model was compared with other previous prediction ***,the discriminating ability,calibration ability,and clinical efficacy of the new model was verified in both the modeling group and the external validation *** Data from univariate and multivariate analyses indicated that the liver-spleen volume ratio,spleen volume change rate,and aspartate aminotransferase were correlated with *** indexes were successfully used to establish the noninvasive prediction *** comparison of the models showed that the established model could better predict HEVs compared with previous *** discriminating ability,calibration ability,and clinical efficacy of the new model were *** The non-invasive prediction model for predicting HEVs in patients with viral cirrhosis was successfully *** new model is reliable for predicting HEV

关键词： Cirrhosis High-risk esophageal varices Non-invasive prediction model liver volume Spleen volume

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Optimization of the future remnant liver:review of the current strategies in Europe

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 350-363页

作者： Riccardo Memeo Maria Conticchio Emmanuel Deshayes Silvio Nadalin Astrid Herrero Boris Guiu Fabrizio Panaro Division of Hepato-Pancreato-Biliary Surgery Department of Surgery“F.Miulli”General HospitalAcquaviva delle FontiBariItaly Policlinico di Bari Aldo Moro UniversityBariItaly Department of Nuclear Medicine Institute du Cancer de Montpellier(ICM)MontpellierFrance INSERM U1194 Montpellier Cancer Research InstituteMontpellier UniversityMontpellierFrance Department of General Visceral and Transplant SurgeryUniversity Hospital TübingenGermany Department of Surgery Division of HBP Surgery and Liver TransplantationSt-Eloi University HospitalMontpellierFrance Department of Radiology St-Eloi University HospitalMontpellierFrance

liver resection still represent the treatment of choice for liver malignancies,but in some cases inadequate future remnant liver(FRL)can lead to post hepatectomy liver failure(PHLF)that still represents the most common cause of death after *** strategies in recent era have been developed in order to generate a compensatory hypertrophy of the FRL,reducing the risk of post hepatectomy liver *** vein embolization,portal vein ligation,and ALLPS are the most popular techniques historically adopted up to *** liver venous deprivation and the radio-embolization are the most recent promising *** even more precise tools to calculate the relationship among volume and function,such as scintigraphy with^(99m)Tc-mebrofenin(HBS),no consensus is still available to define which of the above mentioned augmentation strategy is more adequate in terms of kind of surgery,complexity of the pathology and quality of liver *** aim of this article is to analyse these different strategies to achieve sufficient FRL.

关键词： liver resection future remnant liver(FRL) liver failure liver volume liver function hypertrophy

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