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Engineering of Reversible Luminescent Probes for Real-Time Intravital Imaging of liver injury and repair

CCS Chemistry 2022年第1期4卷 356-368页

作者： Xiao Liu Linhui He Xiangyang Gong Yue Yang Dan Cheng Juanjuan Peng Lu Wang Xiao-Bing Zhang Lin Yuan State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 State Key Laboratory of Natural Medicines School of Basic Medical Sciences and Clinical PharmacyChina Pharmaceutical UniversityNanjingJiangsu 211198 Department of Chemical Biology Max Planck Institute for Medical ResearchHeidelberg 69120

As the major organ for drug metabolism and detoxification,the liver is prone to damage and severely impaired *** treatment of liver diseases is based on a clear understanding of the process underlying liver injury and ***,intravital real-time imaging of liver injury and repair is still limited due to the lack of in vivo reversible visualization *** this end,we proposed a rational design strategy for the development of a reversible upconversion luminescence nanoprobe that allows real-time and in vivo imaging of liver injury and repair *** a proof of concept,we first developed a small molecule probe NB3 which can reversibly respond to related analytes of early liver injury[peroxynitrite(ONOO−)]and liver repair[glutathione(GSH)].The small molecule probe was then integrated with a core–shell upconversion nanoparticle to form a sophisticated *** with traditional small molecule probes,this nanoprobe exhibited a higher selectivity to ONOO−,longer retention time in liver,and wider dynamic response range to GSH after oxidation by ONOO−.The novel nanoprobe facilitated the successful monitoring and discrimination among the different degrees of liver injury and repair in a mouse model.

关键词： luminescent probes liver injury and repair fluorescence imaging peroxynitrite GSH

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