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liquid biopsy approach to pancreatic cancer

World Journal of Gastrointestinal Oncology 2021年第10期13卷 1263-1287页

作者： Sonia Perales Carolina Torres Cristina Jimenez-Luna Jose Prados Joaquina Martinez-Galan Jose Manuel Sanchez-Manas Octavio Caba Department of Biochemistry and Molecular Biology I Faculty of SciencesUniversity of GranadaGranada 18071Spain Department of Biochemistry and Molecular Biology III and Immunology Faculty of SciencesUniversity of GranadaGranada 18071Spain Institute of Biopathology and Regenerative Medicine(IBIMER) Center of Biomedical Research(CIBM)University of GranadaGranada 18100Spain Department of Medical Oncology Hospital Universitario Virgen de las NievesGranada 18011Spain School for International Postgraduate Studies University of GranadaGranada 18071Spain

Pancreatic cancer(PC)continues to pose a major clinical *** has been little improvement in patient survival over the past few decades,and it is projected to become the second leading cause of cancer mortality by *** dismal 5-year survival rate of less than 10%after the diagnosis is attributable to the lack of early symptoms,the absence of specific biomarkers for an early diagnosis,and the inadequacy of available *** patients are diagnosed when the disease has already metastasized and cannot be *** interception is vital,actively intervening in the malignization process before the development of a full-blown advanced *** early diagnosis of PC has a dramatic impact on the survival of patients,and improved techniques are urgently needed to detect and evaluate this disease at an early *** is difficult to obtain tissue biopsies from the pancreas due to its anatomical position;however,liquid biopsies are readily available and can provide useful information for the diagnosis,prognosis,stratification,and follow-up of patients with PC and for the design of individually tailored *** aim of this review was to provide an update of the latest advances in knowledge on the application of carbohydrates,proteins,cell-free nucleic acids,circulating tumor cells,metabo-lome compounds,exosomes,and platelets in blood as potential biomarkers for PC,focusing on their clinical relevance and potential for improving patient outcomes.

关键词： Pancreatic cancer Biomarkers liquid biopsy Clinical management Cancer interception Cancer monitoring

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liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids

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World Journal of Gastroenterology 2017年第31期23卷 5650-5668页

作者： wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji division of digestive surgery department of surgery kyoto prefectural university of medicine

Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called "liquid biopsy" is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Biomarker liquid biopsy Circulating tumor cells Cell-free nucleic acids

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liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1654-1664页

作者： Guillermo Valenzuela Mauricio Burotto Katherine Marcelain Jaime Gonzalez-Montero Department of Basic and Clinical Oncology University of ChileSantiago 8380453Chile Department of Internal Medicine Hospital del SalvadorSantiago 7500922Chile Department of Oncology Bradford-Hill Clinical Research CenterSantiago 8420383Chile

Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy by affording treatments directed against the epidermal growth factor receptor(EGFR) and other anti-angiogenic therapies. However, the survival benefit conferred by these therapies remains variable and difficult to predict, owing to the high level of molecular heterogeneity among patients with CRC. Although classification into consensus molecular subtypes could optimize response prediction to targeted therapies, the acquisition of resistance mutations to targeted therapy is, in part, responsible for the lack of response in some patients. However, the acquisition of such mutations can induce challenges in clinical practice. The utility of liquid biopsy to detect resistance mutations against anti-EGFR therapy has recently been described. This approach may constitute a new standard in the decision algorithm for targeted CRC therapy.

关键词： Colorectal neoplasms Precision medicine liquid biopsy Cetuximab Panitumumab

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liquid biopsy of gastric cancer patients:Circulating tumor cells and cell-free nucleic acids

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World Journal of Gastroenterology 2014年第12期20卷 3265-3286页

作者： Masahiro Tsujiura Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Atsushi Shiozaki Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of Medicine

To improve the clinical outcomes of cancer patients, early detection and accurate monitoring of diseases are necessary. Numerous genetic and epigenetic alterations contribute to oncogenesis and cancer progression, and analyses of these changes have been increasingly utilized for diagnostic, prognostic and therapeutic purposes in malignant diseases including gastric cancer (GC). Surgical and/or biopsy specimens are generally used to understand the tumor-associated alterations; however, those approaches cannot always be performed because of their invasive characteristics and may fail to reflect current tumor dynamics and drug sensitivities, which may change during the therapeutic process. Therefore, the importance of developing a non-invasive biomarker with the ability to monitor real-time tumor dynamics should be emphasized. This concept, so called “liquid biopsy”, would provide an ideal therapeutic strategy for an individual cancer patient and would facilitate the development of “tailor-made” cancer management programs. In the blood of cancer patients, the presence and potent utilities of circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) such as DNA, mRNA and microRNA have been recognized, and their clinical relevance is attracting considerable attention. In this review, we discuss recent developments in this research field as well as the relevance and future perspectives of CTCs and cfNAs in cancer patients, especially focusing on GC.

关键词： Gastric cancer Biomarker liquid biopsy Circulating tumor cells Cell-free nucleic acids MicroRNA

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liquid biopsy in cholangiocarcinoma:Current status and future perspectives

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 332-350页

作者： Gianluca Rompianesi Marcello Di Martino Alex Gordon-Weeks Roberto Montalti Roberto Troisi Hepato-Bilio-Pancreatic Minimally Invasive and Robotic Surgery UnitDepartment of Clinical Medicine and SurgeryFederico II University HospitalNapoli 80131Italy Hepato-Bilio-Pancreatic Surgery Unit Department of General and Digestive SurgeryHospital Universitario La PrincesaMadrid 28006Spain Nuffield Department of Surgical Sciences University of OxfordOxford OX39DUUnited Kingdom

Cholangiocarcinoma(CCA)are a heterogeneous group of tumors in terms of aetiology,natural history,morphological subtypes,molecular alterations and management,but all sharing complex diagnosis,management,and poor *** mutated genes and epigenetic changes have been detected in CCA,with the potential to identify diagnostic and prognostic biomarkers and therapeutic *** tumoral components and genetic material is therefore crucial for the diagnosis,management and selection of targeted therapies;but sampling tumor tissue,when possible,is often risky and difficult to be repeated at different time *** biopsy(LB)represents a way to overcome these issues and comprises a diverse group of methodologies centering around detection of tumor biomarkers from fluid *** to the traditional tissue sampling methods LB is less invasive and can be serially repeated,allowing a real-time monitoring of the tumor genetic profile or the response to *** this review,we analysis the current evidence on the possible roles of LB(circulating DNA,circulating RNA,exosomes,cytokines)in the diagnosis and management of patients affected by CCA.

关键词： liquid biopsy Cholangiocarcinoma Circulating biomarkers Biliary tumors Circulating DNA Circulating RNA Exosomes Cytokines

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liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco M Jesús Fernández Aceñero Luis Ortega Medina Department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA Molecular

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liquid biopsy and blood-based minimal residual disease evaluation in multiple myeloma

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Oncology Research 2023年第3期31卷 271-274页

作者： ALESSANDRO GOZZETTI MONICA BOCCHIA Division of Hematology University of SienaAzienda Ospedaliera UniversitariaSiena53100Italy

Novel drug availability has increased the depth of response and revolutionised the outcomes of multiple myeloma *** residual disease evaluation is a surrogate for progression-free survival and overall survival and has become widely used not-only in clinical trials but also in daily patient *** marrow aspiration is the gold standard for response evaluation,but due to the patchy nature of myeloma,false negatives are *** biopsy and blood-based minimal residual disease evaluation consider circulating plasma cells,mass spectrometry or circulating tumour *** approach is less invasive,can provide a more comprehensive picture of the disease and could become the future of response evaluation in multiple myeloma patients.

关键词： Myeloma liquid biopsy Minimal residual disease

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liquid biopsy in colorectal cancer:No longer young,but not yet old

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World Journal of Gastroenterology 2022年第15期28卷 1503-1507页

作者： Giandomenico Roviello Daniele Lavacchi Lorenzo Antonuzzo Martina Catalano Enrico Mini Department of Health Sciences Section of Clinical Pharmacology and OncologyUniversity of FlorenceFirenze 50139Italy Clinical Oncology Unit AOU CareggiFirenze 50134Italy Department of Experimental and Clinical Medicine University of FirenzeFirenze 50134Italy School of Human Health Sciences University of FlorenceFlorence 50134Italy

Colorectal cancer(CRC)is one of the most prevalent cancers and the second leading cause of cancer-related deaths *** treatment strategy employed in CRC patients is becoming highly dependent on molecular characteristics present at diagnosis and during *** biopsy is an emerging field in the management of this cancer,and its relevance as a potential diagnostic,prognostic,monitoring,and therapeutic tool makes it a viable strategy in the clinical management of CRC *** biopsy also has certain limitations,but these limitations seem to be at the reach of near-future technological *** this letter,we focus on the clinical perspectives of liquid biopsy in CRC with particular regard to the various biomarkers recently identified that have been shown to be potentially useful in multiple aspects of early stage or metastatic CRC.

关键词： Colorectal cancer liquid biopsy Circulating tumor DNA Diagnosis Prognosis Targeted therapy

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liquid biopsy:Precise diagnosis and therapy for cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 362-365页

作者： Si-Qin Wang Chu-Xing Chai Bi-Rong Wang Feng Zhu Dan Shang Min Li Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Breast and Thyroid Surgery Wuhan Fourth HospitalPuai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

The following letter to the editor highlights the review titled“liquid biopsy in cholangiocarcinoma:Current status and future perspective”in World J Gastrointest Oncol 2021;13:*** is necessary to realize individuali... 详细信息

关键词： liquid biopsy Cholangiocarcinoma Diagnosis Therapy Precision medicine

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liquid biopsy:expanding the frontier of circulating biomarker discovery and validation in breast cancer

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Cancer Drug Resistance 2019年第4期2卷 1215-1223页

作者： Philip CMiller Dorraya El-Ashry Marc ELippman Department of Oncology Lombardi Comprehensive Cancer CenterGeorgetown University School of MedicineWashington DCWA 20007USA Breast Cancer Research Foundation New YorkNY 10036USA Department of Laboratory Medicine and Pathology Masonic Cancer CenterUniversity of MinnesotaMinneapolisMN 55455USA

liquid biopsies represent an attractive,minimally-invasive alternative to surgical sampling or complex imaging of breast cancer and breast cancer *** we present a summary of the major biomarker components often evaluated in liquid biopsy samples from patients with breast cancer,including circulating tumor cells,circulating cell-free tumor DNA,and cancer-associated plasma *** discuss recent advancements in methods of detection and use of these biomarkers in breast ***,we highlight some of our own recent contributions to breast cancer liquid biopsy,including the identification and characterization of circulating Cancer Associated Fibroblasts.

关键词： liquid biopsy breast cancer cell-free tumor DNA CTC cancer associated fibroblast

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