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Three-dimensional models:from cell culture to Patient-Derived Organoid and its application to future liposarcoma research

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Oncology Research 2025年第1期33卷 1-13页

作者： SAYUMI TAHARA SYDNEY RENTSCH FERNANDA COSTAS CASAL DE FARIA PATRICIA SARCHET ROMA KARNA FEDERICA CALORE RAPHAEL E.POLLOCK Department of Surgery Division of Surgical OncologyThe James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA Department of Cancer Biology and Genetics The James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other *** to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma *** cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under *** vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell ***,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)***,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between *** the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-Derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy *** this review,we first provide a general overview of 3D cell cultures compared to 2D cell *** then focus on one of the recent 3D cell culture applications,Patient-Derived Organoids(PDOs),summarizing and discussing several PDO ***,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma.

关键词： Cell culture liposarcoma Patient-Derived Organoid(PDO) Spheroid Three-dimensional(3D)cell culture

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Radiation-Induced liposarcoma of the Groin in a Patient with Prior Vulvar Cancer: A Case Report and Literature Review

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Journal of Cancer Therapy 2025年第1期16卷 28-37页

作者： Lorena Munoz Guzman William Manning Valentina Zanfagnin Kyle M. Devins Fantine Giap Andrea Russo Annekathryn Goodman Department of Obstetrics and Gynecology Massachusetts General Hospital Boston USA Department of Pathology Massachusetts General Hospital Boston USA Department of Radiation Oncology Massachusetts General Hospital Boston USA

Radiation-induced sarcomas (RIS) are rare but severe long-term complications of radiotherapy (RT). They typically arise years after exposure to ionizing radiation used to treat primary malignancies and complicate patient outcomes. Determining the risk associated with these radiation-induced cancers is challenging due to confounding factors such as lifestyle and genetic predisposition. liposarcomas, which are the most common type of soft tissue sarcomas, originate from adipose tissue and can develop as a late complication of RT. Although they account for a significant portion of soft tissue sarcomas, radiation-induced liposarcomas are still considered rare, making them a noteworthy diagnostic and therapeutic concern. In this report, we present a rare case of radiation-induced dedifferentiated liposarcoma arising 12 years after RT for vulvar cancer. The patient presented with a mass in the groin, which was initially suspected to be a local recurrence. Imaging studies revealed a suspicious lesion on PET/CT, while MRI showed no significant findings. Histopathological evaluation confirmed the diagnosis of dedifferentiated liposarcoma. Surgical resection was performed with a focus on achieving negative margins. A literature review identified nine similar cases, with five being pleomorphic liposarcomas. The average time to presentation was 15 years (interval 3 - 47 years), with a mean radiation dose of 62 Gy. This case highlights the importance of long-term follow-up for cancer survivors and the need for vigilance in diagnosing secondary malignancies following RT.

关键词： Radiation-Induced Neoplasms liposarcoma Radiotherapy Vulvar Neoplasms

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liposarcoma of the stomach: Report of two cases and review of the literature

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World Journal of Gastroenterology 2018年第25期24卷 2776-2784页

作者： Wen-Zhe Kang Li-Yan Xue Gui-Qi Wang Fu-Hai Ma Xiao-Long Feng Lei Guo Yang Li Wei-Kun Li Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscope National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.

关键词： Pathology Signs and symptoms Diagnosis liposarcoma Therapeutics

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Primary liposarcoma of gallbladder diagnosed by preoperative imagings: A case report and review of literature

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World Journal of Gastroenterology 2006年第9期12卷 1472-1475页

作者： Takashi Hamada Kentaro Yamagiwa Yuko Okanami Koji Fujii Ikuo Nakamura Shugo Mizuno Hajime Yokoi Shuji Isaji Shinji Uemoto The First Department of Surgery Mie University School of Medicine 2-174 EdobashiTsuMieJapan

A 49-year-old Japanese woman was referred to our department because of high fever and a huge abdominal mass. Computed tomography （CT） and magnetic resonance （MR） imagings revealed a tumor, about 30 cm in diameter, occupied the right hepatic lobe and the peritoneal cavity. Abdominal angiography showed that the tumor was fed mainly by the cystic artery. We preoperatively diagnosed angiosarcoma of the gallbladder and performed tumor resection with cholecystectomy because the tumor was almost casplated, however the posterior wall of the gallbladder attached to the tumor firmly. Histologically, the tumor was composed of spindle cells including lipoblasts with cellular pleomorphism, which were also detected in the muscular layer of the gallbladder. We finally diagnosed pleomorphic liposarcoma of the gallbladder. At 10 mo and 29 mo after the first operation, she underwent two more operations because of recurrence. Now she has a good quality of life 3 years and 6 mo after the first operation.

关键词： liposarcoma Gallbladder Liver Pleomorphic type Recurrence

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liposarcoma of the breast arising in a malignant phyllodes tumor:A case report and review of the literature

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World Journal of Clinical Oncology 2015年第5期6卷 174-178页

作者： Malgorzata Banys-Paluchowski Eike Burandt Alexander Quaas Waldemar Wilczak Stefan Geist Guido Sauter Natalia Krawczyk Klaus Pietzner Peter Paluchowski Department of Obstetrics and Gynecology Marienkrankenhaus Hamburg22087 HamburgGermany Department of Pathology University of Hamburg Department of Obstetrics and Gynecology Regio Klinikum Pinneberg25421 PinnebergGermany Department of Obstetrics and Gynecology University of Duesseldorf Department of Obstetrics and Gynecology University of Berlin-Charite

liposarcoma of the breast is a very rare malignant tumor. It can clinically manifest as a palpable breast mass and mimic primary breast cancer. We report an unusual case of a 51-year-old female who presented with an asymptomatic right breast mass, which was histologically diagnosed as well differentiated liposarcoma arisen within malignant phyllodes tumor. The patient underwent breast conserving surgery, received no adjuvant treatment and is disease-free after 2 years. Radiological and histopathological features are presented and described in detail. Data from the literature are presented and therapy recommendations discussed.

关键词： liposarcoma Soft tissue sarcoma Breast cancer Phyllodes tumor Rare malignancies

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Huge primary dedifferentiated pancreatic liposarcoma mimicking carcinosarcoma in a young female: A case report

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World Journal of Clinical Cases 2019年第11期7卷 1344-1350页

作者： Zhe Liu Wu-Feng Fan Gui-Chen Li Jin Long Yuan-Hong Xu Gang Ma Department of Pancreatic-Biliary Surgery First Hospital of China Medical University

BACKGROUND Pancreatic liposarcoma is a rare tumor. According to a literature review, the patient described in this study is the seventh case of pancreatic liposarcoma reported in the English literature and the third case of dedifferentiated liposarcoma. Furthermore, this case had the largest primary tumor volume, and a primary pancreatic liposarcoma was diagnosed based on sufficient evidence. CASE SUMMARY We here report a rare case of a 28-year-old female with a huge dedifferentiated liposarcoma in the pancreatic tail. In June 2015, the patient underwent distal pancreatectomy with splenectomy. During the operation, a huge liposarcoma of approximately 28.0 cm × 19.0 cm × 8.0 cm was found, which had a yellow and white fish-like incisal surface. Based on both pathology and MDM2 gene amplification, the tumor was diagnosed as a dedifferentiated liposarcoma. The patient was treated with surgery but declined postoperative chemotherapy. She was well at the 26-mo follow-up, and no relapse was observed. CONCLUSION Pancreatic liposarcoma has a low incidence. Chemotherapy should be included in the treatment regimens. Complete resection is the only effective treatment.

关键词： Pancreatic liposarcoma Huge tumor Distal pancreatectomy and splenectomy Chemotherapy Case report

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Devascularization of the superior mesenteric vein without reconstruction during surgery for retroperitoneal liposarcoma: A case report and review of literature

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World Journal of Gastroenterology 2018年第22期24卷 2406-2412页

作者： Run-Chen Miao Yong Wan Xiao-Gang Zhang Xing Zhang Yan Deng Chang Liu Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University

A 61-year-old female patient with chronic hepatitis B virus infection was diagnosed with liposarcoma in a community hospital. Fine needle aspiration biopsy confirmed the diagnosis of well-differentiated liposarcoma. Abdominal computed tomographic angiography(CTA) showed that the mass adhered to and constricted the main trunk and branch of the superior mesenteric vein(SMV), especially the ileocolic vein, and collateral circulation was observed during the vascular reconstruction scan. The abdominal liposarcoma was resected. Because of the collateral circulation, devascularization of the SMV was attempted, and we resected the eroded SMV. The condition of the blood vessels was evaluated 20 d after surgery using CTA, which showed that the SMV had disappeared. Significant improvements in SMV collateral circulation and the inferior mesenteric vein were observed after vascular reconstruction. The patient had an uneventful postoperative course except for transient gastroplegia. Twenty months after surgery, the patient had a recurrence of liposarcoma. She underwent tumor resection to remove the distal small intestine and right hemicolon. We learned that(1) direct devascularization of the main SMV trunkwithout a vein graft is possible. The presence of collateralcirculation can increase the success rate of patientsundergoing radical surgery and prevent the occurrence ofserious postoperative complications. In addition,(2) thiscase demonstrated the clinical value of 3 D reconstruction.

关键词： Superior mesenteric vein Retroperitoneal liposarcoma Surgery

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Giant liposarcoma of the esophagus: A case report

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World Journal of Gastroenterology 2015年第33期21卷 9827-9832页

作者： Zhi-Chao Lin Xiang-Zhen Chang Xiu-Fang Huang Chun-Lai Zhang Geng-Sheng Yu Shuo-Yun Wu Min Ye Jian-Xing He Department of Thoracic Surgery Jiangmen Central Hospital Affiliated Jiangmen Hospital of Sun Yat-sen University Editorial Department Chinese Journal of Microsurgerythe First Affiliated Hospital of Sun Yat-sen University Department of Pathology Jiangmen Central Hospital Department of Respiratory Medicine Jiangmen Central Hospital Department of Oncology Jiangmen Central Hospital Department of Thoracic Surgery the First Affiliated Hospital of Guangzhou Medical University

liposarcomas rarely develop in the aerodigestive ***,we present a primary esophageal liposarcoma that was discovered between the T3 and T7 levels of the esophagus during right pleural exploration of a 51-year-old male *** patient had presented with non-specific symptoms,including progressive dysphagia over the previous 6 mo,without complaints of chest or epigastric pain,regurgitation,or weight loss.A radical three-hole esophagectomy was *** tumor was extremely large(14 cm × 7.0 cm × 6.5 cm),but completely *** histological examination,the tumor was diagnosed as a giant,well-differentiated esophageal liposarcoma with a dedifferentiated ***-specific radiological and endoscopic results during the clinical work-up delayed diagnosis until post-operative histology was *** this report,the clinical,radiological and endoscopic diagnostic challenges specific to the case are discussed,as well as the surgical and pathological findings.

关键词： Achalasia Esophagectomy Esophagus liposarcoma

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Dedifferentiated orbital liposarcoma: a case report

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 452-453页

作者： Jing-Xue Zhang Jian-Min Ma and Ning-Li Wang Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100730 China

AIM: To report the abnormal type of the orbital liposarcoma-dedifferentiated subtype in a patient. METHODS: A case report. RESULTS: A 23 years old Chinese woman with a recurrence of right-sided proptosis was evaluated. Ocular examination revealed proptosis of the right eye with chemosis, hyperemia and limitation of eye movements. Magnetic resonance imaging scanning showed an irregular shaped tumor in the right orbit. The tumor resection was done with a clinical diagnosis of malignant tumor. Histopathological findings revealed the diagnosis of dedifferentiated liposarcoma. CONCLUSION: The rare occurrence of this tumour should be kept in mind while dealing with orbital tumours.

关键词： orbit liposarcoma tumour

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Primary duodenal dedifferentiated liposarcoma:A case report and literature review

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World Journal of Clinical Cases 2022年第6期10卷 2007-2014页

作者： Nah Ihm Kim Ji Shin Lee Chan Choi Jong Hee Nam Yoo Duk Choi Hee Joon Kim Sung Sun Kim Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Dedifferentiated liposarcoma(DDLPS)is an extremely rare neoplasm that exhibits various *** tumor is characterized by immunoreactivity to MDM2 and CDK4 and can be confirmed by detecting MDM2 amplification via fluorescence in situ hybridization(FISH).Herein,we report an unusual case of DDLPS arising from the *** SUMMARY A 64-year-old man presented with repeated abdominal pain and weight *** studies revealed a mass of the duodenum involving the *** patient was treated with pylorus-preserving ***,the tumor showed a high-grade *** demonstrated that the tumor cells were positive for MDM2 and CDK4 ***2 amplification was detected via FISH,leading to the final diagnosis of *** surgery,the patient was treated in the intensive care unit due to peritonitis,and died 60 d after *** To the best of the authors’knowledge,this is the first case of primary duodenal DDLPS in Korea and the third case in the English-language *** must be taken not to misdiagnose DDLPS as another high-grade *** should be in the differential diagnosis list.

关键词： liposarcoma Primary Small bowel Duodenum Immunohistochemistry Case report

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