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Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions

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Food Science and Human Wellness 2023年第6期12卷 2221-2231页

作者： Hechun Liu Feng Wang Hui Xia Da Pan Ligang Yang Shaokang Wang Feng Zhao Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Endocrinology and Metabolism The First Affi liated Hospital of Nanjing Medical UniversityNanjing 210029China Tianjin Institute of Environmental and Operational Medicine Tianjin 300050China Research Center of Fatty Acid and Human Health Qingdao UniversityQingdao 266000China

Dietary omega-3 polyunsaturated fatty acids(ω-3 PUFAs)can be classifi ed into animal-and plant-derivedω-3 *** with type 2 diabetes(T2DM)are frequently accompanied by dyslipidemia,which is closely related to the high-density lipoprotein(HDL-C)subfractions *** study aimed to determine the effects of different sourcesω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with *** T2DM patients with dyslipidemia were randomly assigned to take 3 g/day fi sh oil(FO,containing eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)),3 g/day perilla oil(PO,containingα-linolenic acid(ALA)),or 3 g/day blend oil(BO,containing EPA,DHA and ALA)for 3 months.90 patients completed the *** was a significant reduction of glycated hemoglobin(HbA1c)in all the *** triglycerides(TG)in the FO group were signifi cantly different with a group×time interaction(P=0.043),which was higher compared with the other two *** serum small HDL-C subfractions in the PO group was higher and the serum large HDL-C subfractions in the PO group was lower than those in the BO and FO ***-derivedω-3 PUFAs are more effective at controlling blood glucose than animal-derivedω-3 ***,animal-derivedω-3 PUFAs have a signifi cant lowering effect on TG compared with plant-derivedω-3 ***,large HDL-C subfractions after animal-derivedω-3 PUFAs intake were higher than plant-derivedω-3 PUFAs intake;while small HDL-C subfractions were *** the animal-and plant-derivedω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia.

关键词： Diabetes Omega-3 polyunsaturated fatty acid lipoprotein subfraction Dyslipidemia

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Effects of Pitavastatin on lipoprotein subfractions and Oxidized Low-density lipoprotein in Patients with Atherosclerosis

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Current Medical Science 2020年第5期40卷 879-884页

作者： Rui-xia XU Yan ZHANG Yue ZHANG Ya-ru WU Xiao-lin LI Yuan-lin GUO Geng LIU Qian DONG Jian-jun LI State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

It has been demonstrated that pitavastatin can significantly reduce low-density lipoprotein(LDL)cholesterol(LDL-C),but its impact on lipoprotein subfractions and oxidized low-density lipoprotein(oxLDL)has not been *** aim of the present study was to investigate the potential effects of pitavastatin on subfractions of LDL and high-density lipoprotein(HDL)as well as oxLDL in untreated patients with coronary atherosclerosis(AS).Thirty-six subjects were enrolled in this study.O f them,18 patients with AS were administered pitavastatin 2 mg/day for 8 weeks and 18 healthy subjects without therapy served as *** plasma lipid profile,lipoprotein subfractions and circulating oxLDL were determined at baseline and 8 weeks *** results showed that pitavastatin treatment indeed not only decreased LDL-C,total cholesterol(TC),triglycerides(TG)and apolipoprotein B(ApoB)levels,and increased HDL cholesterol(HDL-C),but also reduced the cholesterol concentration of all of the LDL subfractions and the percentage of intermediate and small LDL ***,pitavastatin could decrease plasma oxLDL ***,a more close correlation was found between oxLDL and LDL-C as well as LDL subfractions after pitavastatin *** concluded that a moderate dose of pitavastatin therapy not only decreases LDL-C and oxLDL concentrations but also improves LDL subfractions in patients with AS.

关键词： pitavastatin atherosclerosis lipoprotein subfraction low-density lipoprotein

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