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Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers

Acta Pharmaceutica Sinica B 2019年第2期9卷 421-432页

作者： Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang Wuya College of Innovation Shenyang Pharmaceutical University School of Chinese Materia Medica Guangzhou University of Chinese Medicine Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University

Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy.

关键词： Docetaxel Nanoassemblies Mono thioether bond linoleic acid Pharmacokinetics Antitumor efficacy

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Concentration of linoleic acid from cottonseed oil by starch complexation

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Chinese Journal of Chemical Engineering 2019年第4期27卷 845-849页

作者： Dan Liang Yufeng Hu Weiting Ma Zhengtang Zhao Siqi Jiang Yichuan Wang Xianming Zhang State Key Laboratory of Heavy Oil Processing China University of Petroleum

The extraction of linoleic acid from fatty acids(FA) of the cottonseed oil using starch–FA complexes was developed for the first time. We showed that starch can form inclusion complexes of different strengths with FA and that the different strengths stem from the differences in chain length, degree of unsaturation, and position of double bonds of FA. The optimal separation conditions were determined as follows: The inclusion temperature is 69 °C, the inclusion time is 30 min, the starch/FA mass ratio is 10:1, and the ratio of the volume of methanol–water solution and the mass of FA is 18:1. Compared to urea inclusion complexation, starch complexation has milder reaction temperature and shorter reaction time. Under these conditions, linoleic acid can be concentrated from 38.9% to 70.04% by one-off extraction. Moreover, the experimental results demonstrate the almost perfect reusability of starch. These results show that starch complexation is a promising method that can be used to obtain highly concentrated linoleic acid from cottonseed oil.

关键词： Starch linoleic acid Starch complexation Starch–FA complex Cottonseed oil

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STUDIES ON BIO-ANTIOXIDANTS——PROOXIDATION OF VITAMIN E ON THE AUTOXIDATION OF linoleic ACID IN SODIUM DODECYL SULFATE MICELLES

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Science China Chemistry 1991年第7期34卷 787-795页

作者：刘中立王丽娟刘有成 National Laboratory of Applied Organic Chemistry and Department of Chemistry Lanzhou University Lanzhou 730000 PRC

The reaction of vitamin E (α-tocopherol) with linoleic acid containing peroxidized linoleic acid has been studied. No significant reaction was found in ethanol solution, whereas in sodium dodecyl sulfate micelles vitamin E reacted rapidly with peroxidized linoleic acid, and thereby induced the peroxidation of linoleic acid, leading to oxygen absorption. The reaction kinetics was studied in detail by u. v. spectroscopy, HPLC and ESR spectroscopy. It was found that the main product was α-tocopherone with α-tocopheroxy radical as the reaction intermediate. A mechanism involving two consecutive bimolecular reactions between peroxidized linoleic acid and a-tocopherol and between peroxidized linoleic acid and a-tocopheroxy radical, with rate constant 2.93 and 6.21 mol/L-1s-1 respectively is proposed. The micellar effect on the reaction is discussed.

关键词： vitamin E per oxidation linoleic acid mieellar effect.

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A Study on the Anticancerous Mechanism of linoleic Acid Polyphase Liposome of Liquid Crystalline State by Means of SAXS and ^(31)P-NMR

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Chinese Science Bulletin 1993年第17期38卷 1437-1442页

作者：孙润广王德华戴正华王子浩张静 Experimental Centre of Shaanxi Normal University Xi'an Chemical Industry Research Institute

In recent years, close attention has been paid to the study of liposomes as the carrier of the anticancerous drug, which has many advantages in the therapeutics, such as increasing the toxicity of the drug. alleviating metamorphosis and immunity reaction; improving the biological utilization ratio of the drug; selectively killing and inhibiting the cancer cells or checking the reproduction of the cancer cells, and so on. At present, peo-

关键词： liquid crystalline pbase polyphase liposomes lamellar-hexagonan phase lamellar-cubic phase linoleic acid.

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The Effect of Parity on Conjugated linoleic Acid(CLA) Content in Milk Fat and CLA-Desaturase Index from Holstein Dairy Cows

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畜牧兽医学报 2009年第S1期40卷 28-33页

作者： HOU Jun-cai LIU Fei LIU Yan-ping HUO Gui-cheng REN Da-xi TI Wei-gang Key Laboratory of Dairy Science Ministry of EducationNortheast Agricultural University College of Food Northeast Agricultural University

The performance of lactating dairy cows and composition of the fatty acids in milk fat were measured to investigate the effect of parity on conjugated linoleic acid(CLA)in milk fat and△~9-desaturase indices from Holstein dairy *** samples of two hundred and thirty-five lactating Holstein dairy cows in north China were *** order to avoid possible confounding effects of diet and season,Holstein cows were fed a single diet and milk was sampled on the same *** average content of cis-9,trans-11 CLA was 5.14 mg/g fatty acids in milk fat,varying between 1.5 and 10.5 mg/g fatty *** average content of cis-9,trans-11 CLA of primiparous cattle was 5.19 mg/g fatty acids in milk fat,while it was 5.11 mg/g fatty acids in multiparous animals,with no significant difference between them(P>0.05).There was a significant(P0.05)in the△~9-desaturase index of cis-9 C18:l and cis-9,trans-11 CLA.

关键词： Parity conjugated linoleic acid(CLA) △9-desaturase indices

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STUDY ON THE FREE RADICALS PRODUCED FROM PHOTOLYSIS OF PEROXIDIZED linoleic ACID BY ESR SPIN TRAPPING TECHNIQUE

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Chinese Science Bulletin 1991年第23期36卷 2004-2007页

作者：赵保路张建朝忻文娟 Institute of Biophysics Academia Sinica Beijing 100080 PRC

Lipid peroxidation of polyunsaturate fatty acid is the main reason for the production of toxic materials in putrid food oil. The free radicals and other products produced from the peroxidation process can damage the membrane, protein and DNA and may induce cancer and other brain, myocardial and vascular diseases. Lipid peroxidation is also an important reason for aging. So it has raised a wide interest and attention of biological and

关键词： free radicals linoleic acid ESR lipid peroxide

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linoleic acid metabolic pathway allows for an efficient increase of intramuscular fat content in pigs

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Journal of Animal Science and Biotechnology 2019年第3期10卷 759-767页

作者： Sofia Gol Rayner Gonzalez-Prendes Lluis Bosch Marc Tor Josep Reixach Ramona N.Pena Joan Estany Department of Animal Science Universitat de Lleida-Agrotecnio Center191 Rovira Roure25198 LleidaCataloniaSpain Department of Chemical Agricultural and Food Technology EngineeringUniversitat de GironaCampus de Montilivi17071 GironaCataloniaSpain Seleccion Batalle S.A. Av.Segadors s/n17421 RiudarenesCataloniaSpain

Background: Intramuscular fat(IMF) content is a relevant trait for high-quality meat products such as dry-cured ham,but increasing IMF has the undesirable correlated effect of decreasing lean ***,there is a need to find selection criteria for IMF independent from lean *** pigs,the proportion of linoleic(C18:2) and arachidonic(C20:4) acids decline with fat deposition and therefore they can be considered as indicators of *** aim of this research was to estimate the genetic variation for C18:2 and C20:4 in IMF and their genetic correlations with IMF and lean growth traits,with the objective to assess their potential as specific biomarkers of *** analysis was conducted using a full-pedigreed Duroc resource line with 91,448 records of body weight and backfat thickness(BT) at 180 days of age and 1371 records of fatty acid composition in the muscle gluteus ***: The heritability estimates for C18:2 and C20:4 in IMF,whether expressed in absolute(mg/g of muscle) or in relative(mg/g of fatty acid) terms,as well as for their ratio(C20:4/C18:2),were high(> 0.40),revealing that the C18:2 to C20:4 pathway is subjected to substantial genetic *** effects were not negligible,with values ranging from8% to 15% of the phenotypic *** genetic correlations of C18:2 and C20:4 with IMF and BT were negative(-0.75 to-0.66,for IMF,and-0.64 to-0.36,for BT),if expressed in relative values,but almost null(-0.04 to 0.07),if expressed in absolute values,except for C18:2 with IMF,which was highly positive(0.88).The ratio of C20:4 to C18:2 also displayed a stronger genetic correlation with IMF(-0.59) than with BT(-0.10).Conclusions: The amount of C18:2 in muscle can be used as an IMF-specific *** for the absolute amount of C18:2 is expected to deliver a similar response outcome as selection for IMF at restrained *** genetic analysis of the C18:2 metabolic pathway may provide new insights into differential fat deposition

关键词： Arachidonic Genetic parameters Intramuscular fat linoleic Meat quality Swine

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STUDIES ON BIO-ANTIOXIDANTS (Ⅴ)——INHIBITION OF AUTOXIDATION OF linoleic ACID BY VITAMIN E, VITAMIN C AND LIPOPHILIC VITAMIN C DERIVATIVES IN MICELLES

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Science China Chemistry 1992年第11期35卷 1307-1314页

作者：刘中立王潘奋刘有成 Notional Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 PRC

The antioxidation activity of vitamin E, vitamin C and lipophilic derivatives of vitaminC, i.e. ascorbyl--6-caprylate, 6-laurate and 6-palmitate, on the autoxidation of linoleic acidwere studied in SDS, Triton X-100 and CTAB micelles. The effect of the lipophilicity ofthe antioxidants and micellar effects on the antioxidation activity are discussed.

关键词： autoxidation antioxidants linoleic acid micellar effect

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Effect of Spraying with GA<sub>3</sub>on the Quality and Oil Content of Syrian Okra Seeds <i>Abelmoschus esculentus</i>(L.)

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American Journal of Plant Sciences 2022年第1期13卷 83-90页

作者： Dima Zolfikar Khrmashow Miteadi Bouras Fahed Sahuni Department of Horticulture Faculty of Agriculture Tishreen University Lattakia Syria Department of Horticulture Second College of Agriculture Aleppo University Aleppo Syria

This study aimed to estimate the effect of spraying of okra plants, Abelmoschus esculentus (L.) with GA3 on the quality and oil content of the seeds. For this, the local okra variety was selected and used, which was growing widespread in the coastal region of Syria. This study was carried out in Al-Haffa area, Lattakia governorate, Syria (with 105 MSL elevation) for two seasons 2019-2020. The results showed that the effect of spraying with GA3 was more evident in the quality of the seeds as well as oil content at 75 ppm concentration with 68.7 g weight of 1000 seeds and 5.31% seed oil percentage. This study also showed that oil of local okra variety seed was rich in the essential fatty acids namely, linoleic, palmitic, oleic, stearic and linolenic, treatment with 75 ppm concentration of GA3 was more effective in the seed content of essential fatty acids with 42.30%, 32.55%, 9.20%, 6.73% and 5.72%, respectively. Finally, our results were indicated that treatment of okra plants at 75 ppm of GA3 enhanced the quality and oil content of seeds compared to the other concentrations.

关键词： Oil Content GA3 Fatty Acids linoleic Palmitic Okra

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Relationship between high dietary fat intake and Parkinson’s disease risk: a meta-analysis

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Neural Regeneration Research 2019年第12期14卷 2156-2163页

作者： Yan Qu Xi Chen Man-Man Xu Qiang Sun Department of Physiology School of Basic Medicine Qingdao University Qingdao Shandong Province China Intensive Care Unit The Affiliated Hospital of Qingdao University Qingdao Shandong Province China

OBJECTIVE: To assess whether dietary fat intake influences Parkinson’s disease risk. DATA SOURCES: We systematically surveyed the Embase and PubMed databases, reviewing manuscripts published prior to October 2018. The following terms were used:(“Paralysis agitans” OR “Parkinson disease” OR “Parkinson” OR “Parkinson’s” OR “Parkinson’s disease”) AND (“fat” OR “dietary fat” OR “dietary fat intake”). DATA SELECTION: Included studies were those with both dietary fat intake and Parkinson’s disease risk as exposure factors. The Newcastle-Ottawa Scale was adapted to investigate the quality of included studies. Stata V12.0 software was used for statistical analysis. OUTCOME MEASURES: The primary outcomes included the relationship between high total energy intake, high total fat intake, and Parkinson’s disease risk. The secondary outcomes included the relationship between different kinds of fatty acids and Parkinson’s disease risk. RESULTS: Nine articles met the inclusion criteria and were incorporated into this meta-analysis. Four studies scored 7 and the other five studies scored 9 on the Newcastle-Ottawa Scale, meaning that all studies were of high quality. Meta-analysis results showed that high total energy intake was associated with an increased risk of Parkinson’s disease (P = 0.000, odds ratio (OR)= 1.49, 95% confidence interval (CI): 1.26–1.75);in contrast, high total fat intake was not associated with Parkinson’s disease risk (P = 0.123, OR = 1.07, 95% CI: 0.91–1.25). Subgroup analysis revealed that polyunsaturated fatty acid intake (P = 0.010, OR = 1.03, 95% CI: 0.88–1.20) reduced the risk of Parkinson’s disease, while arachidonic acid (P = 0.026, OR = 1.15, 95% CI: 0.97–1.37) and cholesterol (P = 0.002, OR = 1.09, 95% CI: 0.92–1.29) both increased the risk of Parkinson’s disease. Subgroup analysis also demonstrated that, although the results were not significant, consumption of n-3 polyunsaturated fatty acids (P = 0.071, OR = 0.88, 95% CI: 0.73–1.05),α-linolenic ac

关键词： nerve regeneration dietary fat Parkinson's disease risk meta-analysis total energy intake polyunsaturated fatty acids arachidonic acid cholesterol α-linolenic acid linoleic acid n-3/n-6 polyunsaturated fatty acid intake ratio monounsaturated fatty acids neural regeneration

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