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Near-infrared light switching nitric oxide nanogenerator with“linkage mechanism”for tumor targeting multimodal synergistic therapy

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Science China Chemistry 2023年第2期66卷 586-600页

作者： Wei Zhang Qize Xuan Qi Zhang Tong Wang Chen Wang Hui Li Chao Chen Ping Wang State Key Laboratory of Bioreactor Engineering Biomedical Nanotechnology CenterSchool of BiotechnologyEast China University of Science and TechnologyShanghai200237China Institute for Environmental Pollution and Health School of Environmental and Chemical EngineeringShanghai UniversityShanghai200444China Department of Bioproducts and Biosystems Engineering University of MinnesotaSt PaulMN55108USA

Gaseous therapy based on nitric oxide(NO),as a potential anti-tumor treatment strategy,has attracted great attention,but the targeted and controlled gas release in the tumor site still remains a *** addressing these difficulties,a near-infrared(NIR)light-triggered NO release nanogenerator with a“linkage mechanism”was designed on the basis of sodium nitroprussidedoped mesoporous Prussian blue nanoparticles,in which the outer structure was modified with p H-sensitive gatekeeper chitosan and tumor-targeting agent folic ***“linkage mechanism”can achieve precise release of NO under the control of photothermal effect at tumor site,which can couple photothermal therapy and gas therapy to address the premature release of gas during ***,the amount of released gas can be controlled by adjusting the irradiation time and laser ***,as-fabricated nanocomposites hold high photothermal conversion efficiency under NIR laser irradiation,resulting in the on-demand release of NO and chemotherapy *** released NO can inhibit the expression of hypoxiainducible factorα(HIF-1α)and alleviate the hypoxic tumor microenvironment,thereby enhancing the efficacy of ***,in vitro and in vivo experiments exhibited remarkable antitumor efficiency,and the synergistic gas/chemo/photothermal therapy of deep tumors was *** findings indicate an effective strategy to stimulate further the development of deep tumor therapy,which may provide new insights into other NO-related medical applications.

关键词： NO generator NIR-trigger NO release linkage mechanism gas therapy targeted synergistic therapy

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Humanoid Design of Mechanical Fingers Using a Motion Coupling and Shape-adaptive linkage mechanism

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Journal of Bionic Engineering 2018年第1期15卷 94-105页

作者： Yi Zhang Hua Deng Guoliang Zhong College of Mechanical & Electrical Engineering Changsha University Changsha 410022 China State Key Laboratory of High-Performance Complex Manufacturing Central South University Changsha 410083 China School of Mechanical and Electrical Engineering Central South University Changsha 410083 China

This paper proposes a novel underactuated finger mechanism based on a motion coupling and shape-adaptive linkage design that combines anthropomorphic free motion and adaptive grasping. The proposed three-joint finger mechanism with one active Degree of Freedom （DOF） consists of a five-linkage meehanism in the proximal phalanx and a mechanism comprising two parallel planar four-bar linkages in the middle phalanx. The respective mechanism allows the simultaneously rotation of their corresponding pha- langes in the plane before making contact with an object, and can fully envelop an object, even if certain phalanges are blocked. The duel parallel four-bar linkage mechanism is adopted to improve the grasping capacity of the distal phalanx. An optimal design of the finger is presented according to anthropomorphic phalanx trajectories and maximized grasping forces obtained with consideration for the angular velocity relationships of the three phalanges and their force transmission performances. The functionality of the proposed finger mechanism is verified through multiple simulations and grasping experiments using a prototype finger.

关键词： humanoid finger underactuated mechanism linkage mechanism adaptive grasp

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Research on the linkage mechanism between Essential Medicine List and Healthcare Insurance List

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Pharmacology & Pharmacy 2021年第11期12卷 247-254页

作者： Linning Chen Jinxi Ding Jiaming Li Xuefang Yao School of International Pharmaceutical Business China Pharmaceutical University Nanjing China School of Health Economics and Management Nanjing University of Chinese Medicine Nanjing China

Objective: To put forward suggestions to improve the linkage mechanism between China’s essential medicine list and healthcare insurance medicine list. Methods: Comparative study of the organization setting, selection criteria, adjustment procedures, and reimbursement of essential medicine list and healthcare insurance medicine list, containing both the foreign experience and China’s status quo. Results: When two lists exist at the same time, they are often managed separately abroad, setting more selection criteria for the essential medicine, and giving the essential medicine a higher payment ratio. The two lists in China are managed and adjusted separately, but lack of connection. As a result, some essential medicines cannot be reimbursed. Conclusion: The two lists’ linkage mechanism needs to be improved. It is recommended to make it clear that essential medicines should be selected from the healthcare insurance medicine l

关键词： Essential Medicine List Healthcare Insurance Medicine List linkage mechanism

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Dynamic Analysis of aSelected Spatial One-DOF linkage mechanism with Friction in Joints

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Journal of Control Science and Engineering 2016年第1期4卷 11-25页

作者： Andrzej Harlecki Andrzej Urbas Department of Mechanics Faculty of Mechanical Engineering and Computer Science University of Bielsko-Biala Willowa 2Bielsko-Biala 43-309 Poland

The dynamic analysis of a one-DOF RSRRR spatial linkage mechanism, including four rotational joints R and one spherical joint S, is presented in the paper. It is assumed that friction occurs in the rotational joints, whereas a spherical joint can be treated as an ideal one. The mechanism in the form of a closed-loop kinematic chain was divided by cut joint technique into two open-loop kinematic chains in place of the spherical joint. Joint coordinates and homogeneous transformation matrices were used to describe the geometry of the system. Equations of the chains＇ motion were derived using formalism of Lagrange equations. Cut joint constraints and reaction forces, acting in the cutting place---i.e, in the spherical joint, have been introduced to complete the equations of motion. As a consequence, a set of differential-algebraic equations has been obtained. In order to solve these equations, a procedure based on differentiation twice of the formulated constraint equations with respect to time has been applied. In order to determine values of friction torques in the rotational joints in each integrating step of the equations of motion, joint forces and torques were calculated using the recursive Newton-Euler algorithm taken from robotics. For the requirements of the method, a model of a rotational joint has been developed. Some examples of results of the numerical calculations made have been presented in the conclusions of the paper.

关键词： Dynamic analysis linkage mechanism friction cut joint technique.

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Driving Torque Reduction in linkage mechanisms Using Joint Compliance for Robot Head

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Chinese Journal of Mechanical Engineering 2015年第5期28卷 888-895页

作者： ZHONG Chunhao YANG Xiaojun Shenzhen Graduate School Harbin Institute of Technology

The conventional linkage mechanisms with compliant joint have been widely studied and implemented for increasing the adaptability of the mechanism to external contacts. However, the analysis of how compliant joints in linkage mechanism can reduce the energy consumption isn＇t still studied deeply. In a mobile service robot head, the actions of blinking the eyes and moving the eyeballs are realized by the planar linkage mechanism respectively. Therefore, minimizing the driving torques through motion trajectories for the linkage mechanism, which will be beneficial to extend the working time for mobile service robots. The dynamic modeling of the linkage mechanism with springs-loaded compliant joint is established. An optimization procedure for obtaining the optimal parameters of springs is proposed for minimizing the max value of driving torques within a range of desired operating conditions. The Simulations prove that the linkage mechanism with compliant joints can effectively reduce the driving torques, and reduce the energy consumption consequently. The framework can also be applied in other similar applications to reduce the driving torque and save energy. Compared with previous efforts, this is the first attempt that the linkage mechanism with complaint joint is applied in the robot head for reducing the driving torque.

关键词： robot head compliant joint linkage mechanism driving torque reduction save energy

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ACCURACY ANALYSIS FOR PLANAR linkage WITH MULTIPLE CLEAR-ANCES AT TURNING PAIRS

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Chinese Journal of Mechanical Engineering 2008年第2期21卷 36-41页

作者： ZHANG Guojun CHENG Qiang SHAO Xinyu LI Peigen State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430074. China

Clearance at turning pair has a strong impact on the kinetic accuracy of linkage, but there is short of a generic model to analyze it so far. Clearance error, input error, and manufacturing tolerance of links are taken into consideration as the random variables synthetically. The kinematics and dynamics accuracy analysis models for planar linkages with multiple clearances at joints are built up as well. At last a typical planar linkage is selected for nurnerical illustration. These models stated in matrix resolve the relativity of output parameter errors of mechanism and therefore are of vital significance for the reliability analysis and synthesis of mechanism with clearances.

关键词： linkage mechanism Clearance error Accuracy

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Development of Air Vehicle with Active Flapping and Twisting of Wing

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Journal of Bionic Engineering 2011年第1期8卷 1-9页

作者： Sangyol Yoon Lac-Hyong Kang Sungho Jo Department of Computer Science Korea Advanced Institute of Science and Technology Daejeon 305-701 Korea Department of Aerospace Engineering Korea Advanced Institute of Science and Technology Daejeon 305-701 Korea

This paper addresses mechanisms for active flapping and twisting of robotic wings and assesses flying effectiveness as a function of twist angle. Unlike the flapping motion of bird wings, insects generally make a twisting motion at the root of their wings while flapping, which makes it possible for them to hover in midair. This work includes the development of a Voice Coil Motor （VCM） because a flapping-wing air vehicle should be assembled with a compact actuator to decrease size and weight. A linkage mechanism is proposed to transform the linear motion of the VCM into the flapping and twisting motions of wings. The assembled flapping-wing air vehicle, whose weight is 2.86 g, produces an average positive vertical force proportional to the twist angle. The force saturates because the twist angle is mechanically limited. This work demonstrates the possibility of developing a flapping-wing air vehicle that can hover in midair using a mechanism that actively twists the roots of wings during flapping.

关键词： biomimetic flapping-wing air vehicle flapping twisting voice coil motor linkage mechanism

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Dynamic analytic model of mechanism with links fabricated from symmetric laminates

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Journal of Central South University of Technology 2006年第6期13卷 624-630页

作者：蔡敢为常平平马存志王汝贵李兆军 College of Mechanical Engineering Guangxi University School of Mechanical Science & Engineering Huazhong University of Science & Technology

A four-bar linkage mechanism with links fabricated from symmetric laminates was studied. The mass matrix of the beam dement was obtained in light of the mass distribution characteristics of composite materials. The stiffness matrix of the beam element was derived from the constitutive equations of each layer and the relationship between the strain distribution and the node displacement of the beam element. The specific damping capacity of the beam element was analyzed according to the strain distribution of the beam element and the strain energy dissipation caused by vibration in each direction of each layer; and the damping coefficients were obtained according to the principle that the total energy dissipation of the beam element was equal to the work done by the equivalent damping force during a cycle of vibration, from which the damping matrix of the dynamic equations was obtained. Using the finite element method, the dynamic analytic model of the mechanism was obtained. The dynamic responses and natural frequency of the mechanism were obtained by simulation, respectively, and those of the simulation obtained by the proposed model were analyzed and compared with the results obtained by the conventional model. The work provides theoretical basis to a certain extent for the further research on nonlinear vibration characteristics and optimum design of this kind of mechanism.

关键词： linkage mechanism finite element method composite materials damping dynamic analysis

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THE APPLICATION OF THE COMPUTER AIDED ANALYSIS IN THE DESIGN OF COALMINE MACHINERY linkageS

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Journal of Coal Science & Engineering(China) 1996年第1期2卷 98-104页

作者：寇子明许步勤沈现军

This paper gives and verifies a mathematical model with only one argument which determines the movement parameters of any point in a plane four-bar linkage on the basis of the analysis of mining machinery linkages. C A A (computer aided analysis) based on the mathemetical model can be used to make not only the quick and accurate analysis and design of mining machinery linkages but also the movement analysis and optimization design of any other plane four-bar linkage.

关键词： linkage mechanism mathematical model computer aided design mining machinery

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Research on mechanisms for University Connotation Construction and High-Quality Employment in the Context of New Quality Productivity

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Journal of Contemporary Educational Research 2024年第9期8卷 171-175页

作者： Shouwei Meng Wenyuan Meng North China University of Water Conservancy and Electric Power Zhengzhou 450046Henan ProvinceChina

The introduction of the concept of new quality productivity has attracted a great deal of attention in the educational ***,there is an urgent need to align it with policy orientation and advancements in science and technology moving *** and universities themselves should be the leaders of advanced thinking and scientific and technological development,and play their due roles in line with the development of the times to provide quality and urgent talents and intellectual *** this reason,this paper proposes that universities should consciously establish a set of regular operation mechanisms,namely,the linkage mechanism between“social demand”and“connotation construction,”and operate regularly under the guarantee of the *** enables universities to lead or grasp the pulse of scientific and technological development,constantly improve the level of connotation construction,promote high-quality employment,and provide high-quality services for modernization and the great rejuvenation of the Chinese nation.

关键词： New quality productivity Social demand Connotation construction linkage mechanism High-quality employment

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