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Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions

Neural Regeneration Research 2022年第1期17卷 25-30页

作者： Peiyuan Huang Zhihao Zhao Liting Duan Department of Biomedical Engineering The Chinese University of Hong KongSha TinHong Kong Special Administrative RegionChina Shun Hing Institute of Advanced Engineering(SHIAE) The Chinese University of Hong KongSha TinHong Kong Special Administrative RegionChina

Dynamic protein-protein interactions are essential for proper cell *** events—physical interactions between the same type of proteins—represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling *** of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction *** emerging optogenetic technology,based on genetically encoded light-sensitive proteins,provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal *** we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.

关键词： cryptochrome 2 homo-interaction intracellular signaling light light-induced protein-protein interaction light-oxygen-voltage-sensing domain light-sensitive proteins optogenetics phytochrome signal transduction

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Optogenetics:a novel optical manipulation tool for medical investigation

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 517-522页

作者： Jun-Ping Yao, Zheng-Qin Yin College of Biology Engineering Chongqing University Chongqing 400044 China Department of Ophthalmology the Third Military Medical University Chongqing 400038 China Chongqing Key Lab of Visual Damage and Regeneration and Restoration Chongqing 400038 China

Optogenetics is a new and rapidly evolving gene and neuroengineering technology that allows optical control of specific populations of neurons without affecting other neurons in the brain at high temporal and spatial resolution. By heterologous expression of the light-sensitive membrane proteins, cell type-specific depolarization or hyperpolarization can be optically induced on a millisecond time scale. Optogenetics has the higher selectivity and specificity compared to traditional electrophysiological techniques and pharmaceutical methods. It has been a novel promising tool for medical research. Because of easy handling, high temporal and spatial precision, optogenetics has been applied to many aspects of nervous system research, such as tactual neural circuit, visual neural circuit, auditory neural circuit and olfactory neural circuit, as well as research of some neurological diseases. The review highlights the recent advances of optogenetics in medical study.

关键词： light-sensitive proteins optogenetics optical manipulation medical

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