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light therapy:a new option for neurodegenerative diseases

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Chinese Medical Journal 2021年第6期134卷 634-645页

作者： Yu-Lu Liu Si-Yi Gong Shu-Ting Xia Ya-Li Wang Hao Peng Yun Shen Chun-Feng Liu Department of Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhouJiangsu 215123China Department of Neurology Suzhou Municipal HospitalNanjing Medical UniversitySuzhouJiangsu 215008China Department of Epidemiology School of Public HealthMedical College of Soochow UniversitySuzhouJiangsu 215006 China Department of Neurology Suqian First HospitalSuqianJiangsu 223800China

Given the increasing incidence of neurodegenerative disease(ND),recent research efforts have intensified the search for curative treatments.Despite significant research,however,existing therapeutic options for ND can only slow down the progression of the disease,but not provide a cure.light therapy(LT)has been used to treat some mental and sleep disorders.This review illustrates recent studies of the use of LT in patients with ND and highlights its potential for clinical applications.The literature was collected from PubMed through June 2020.Selected studies were primarily English articles or articles that could be obtained with English abstracts and Chinese main text.Articles were not limited by type.Additional potential publications were also identified from the bibliographies of identified articles and the authors’reference libraries.The identified literature suggests that LT is a safe and convenient physical method of treatment.It may alleviate sleep disorders,depression,cognitive function,and other clinical symptoms.However,some studies have reported limited or no effects.Therefore,LT represents an attractive therapeutic approach for further investigation in ND.LT is an effective physical form of therapy and a new direction for research into treatments for ND.However,it requires further animal experiments to elucidate mechanisms of action and large,double-blind,randomized,and controlled trials to explore true efficacy in patients with ND.

关键词： Neurodegenerative diseases light therapy Circadian rhythm

Red organic light-emitting diodes based photobiomodulation therapy enabling prominent hair growth

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Nano Research 2023年第5期16卷 7164-7170页

作者： Shuang-Qiao Sun Jing-Jing Shen Yu-Fei Wang Yu-Tong Jiang Lin-Fu Chen Hua Xin Jiang-Nan Wang Xiao-Bo Shi Xiao-Zhao Zhu Qi Sun Liang-Sheng Liao Qian Chen Man-Keung Fung Shuit-Tong Lee Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow University199 Ren'ai RoadSuzhou 215123China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsZhuhai MUST Science and Technology Research InstituteMacao University of Science and TechnologyTaipa 999078MacaoChina 3 Institute of Organic Optoelectronics Jiangsu Industrial Technology Research Institute(JITRI)1198 Fenhu DadaoWujiangSuzhou 215200China

Hair loss can cause psychological distress.Here,red organic light-emitting diode(OLED)light source is first introduced as the photobiomodulation therapy(PBMT)for hair growth and demonstrated as a promising and non-invasive therapeutic modality for alopecia.OLED exhibits unique advantages of homogeneous irradiation,flexible in form factor,less heat generation.These features enable OLED to be an ideal candidate for wearable PBMT light sources.A systematic study of using red OLEDs to facilitate hair growth was conducted.The results show that OLEDs excellently promote hair regrowth.OLED irradiation can increase the length of the hair by a factor of 1.5 as compared to the control,the hair regrowth area is enlarged by over 3 times after 20 days of treatments.Moreover,the mechanism of OLED that stimulates hair follicle regeneration is investigated invivo by conducting a systematic controlled experiments on mice with or without OLED PBMT.Based on the comprehensive histological and immunofluorescence staining studies,two key factors are identified for red OLEDs to facilitate hair follicle regeneration:(i)increased autophagy during the anagen phase of the hair growth cycle;(ii)increased blood oxygen content promoted by the accelerated microvascular blood flow.

关键词： red organic light-emitting diode(OLED) light therapy hair growth autophagy oxygen saturation

The Antidepressant Effect of light therapy from Retinal Projections

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Neuroscience Bulletin 2018年第2期34卷 359-368页

作者： Xiaotao Li Xiang Li The Brain Cognition and Brain Disease Institute for Collaborative Research of SIAT at CAS and the McGovern Institute at MIT Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences McGovern Institute for Brain Research Department of Brain and Cognitive Sciences Massachusetts Institute of Technology

Observations from clinical trials have frequently demonstrated that light therapy can be an effective therapy for seasonal and non-seasonal major depression. Despite the fact that light therapy is known to have several advantages over antidepressant drugs like a low cost,minimal side-effects, and fast onset of therapeutic effect,the mechanism underlying light therapy remains unclear.So far, it is known that light therapy modulates mood states and cognitive functions, involving circadian and noncircadian pathways from retinas into brain. In this review,we discuss the therapeutic effect of light on major depression and its relationship to direct retinal projections in the brain. We finally emphasize the function of the retino-raphe projection in modulating serotonin activity,which probably underlies the antidepressant effect of light therapy for depression.

关键词： light therapy Depression Retinal projection Serotonin Opsin

Antiviral optical techniques as a possible novel approach to COVID-19 treatment

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 1-18页

作者： Fereshteh Moshfegh Farshad Khosraviani Negar Moghaddasi Seyedeh Fatemeh Seyed Javadi Limoodi Ebrahim Boluki Department of Dentistry New Vision University 1a Evgeni Mikeladze StreetTbilisi 0159Georgia School of Dentistry University of California Los Angeles10833 Le Conte CHSCA 90095USA School of Dentistry Shiraz University of Medical Sciences Zand Street P.O. School of Dentistry Tehran University of Medical Sciences North Karegar Street P.O. Blood Transfusion Research Center High Institute for Research&Education in Transfusion Medicine TehranIran

The current pandemic SARS-CoV-2(also known as 2019-nCoV and COVID-19)viral infection is growing globally and has created a disastrous situation all over the world.One of the biggest challenges is that no drugs are available to treat this life-threatening disease.As no drugs are available for definitive treatment of this disease and the mortality rate is very high,there is an utmost need to cure the infection using novel technologies.This study will point out some new antimicrobial technologies that have great potentials for eradicating and preventing emerging infections.They can be considered as treatments of choice for viral infections in the future.

关键词： SARS-CoV-2 COVID-19 light therapy photodynamic therapy photocatalysis ARDS

Photon penetration depth in human brain for light stimulation and treatment:A realistic Monte Carlo simulation study

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 59-68页

作者： Ting Li Chang Xue Pengbo Wang Yan Li Lanhui Wu Institute of Biomedical Engineering Chinese Academy of Medical Science and Peking Union Medical College 300192 TianjinP.R.China State Key Lab Elect Thin Film&Integrated Device and Department of Biomedical Engineering University of Electronic Science&Technology of China Chengdu 610054 P.R.China Design Center Avic Beijing Keeven Aviation Instrument Co. Ltd China Aviation Industry Corporation Beijing 100098P.R.China

light has been clinically utilized as a stimulation in medical treatment,such as Low-level laser therapy and photodynamic thenapy,which has been more and more widely accepted in public.The penetration depth of the treatment light is important for precision treatment and safety control.The isue of light penetration has been highlighted in biomedical optics field for decades.However,quantitative research is sparse and even there are conflicts of view on the capability of near-infrared light penet ration into brain tissue.This study attempts to quantitatively revisit this issue by innovative high-realistic 3D Monte Caro modeling of stimulated light penetnation within high precision Visible Chinese human head.The properties of light,such as its wave-length,ilumination profle and size are concern in this study.We made stra ightforward and quantitative comparisons among the ffects by the light properties(i.e.,wavelengths:660,810 and 980 nn;beam types:Gaussi an and flat beamn;bear dianeters:0,2,4 and 6 cm)which are in the range of light treatment.The findings include about 3%of light dosage within brain tisue;the combination of Gaussian beam and 810nm light make the max imum light penetration(>5cm),which allows light to cross through gray matter into white mater.This study offered us,the first time as we know,quantitative guide for light stimulation parameter optimization in medical treatment.

关键词： Penetration depth light therapy light propagation MCVM human brain