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Effect of lifestyle modification on hepatocellular carcinoma incidence and mortality among patients with chronic hepatitis B

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World Journal of Gastroenterology 2023年第24期29卷 3843-3854页

作者： Yewan Park Danbee Kang Dong Hyun Sinn Hyunsoo Kim Yun Soo Hong Juhee Cho Geum-Youn Gwak Department of Internal Medicine Kyung Hee University HospitalSeoul 02447South Korea Department of Digital Health SAIHSTSungkyunkwan UniversitySeoul 06355South Korea Department of Clinical Research Design and Evaluation SAIHSTSungkyunkwan UniversitySeoul 06355South Korea Center for Clinical Epidemiology Samsung Medical CenterSungkyunkwan UniversitySeoul 06351South Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Departments of Epidemiology and Medicine and Welch Center for PreventionEpidemiology and Clinical ResearchJohns Hopkins Medical InstitutionsBaltimoreMD 21287United States

BACKGROUND Research exploring the influence of healthier lifestyle modification(LSM)on the risk of hepatocellular carcinoma(HCC)in patients with chronic hepatitis B(CHB)is *** To emulate a target trial to determine the effect of LSM on HCC incidence and mortality among patients with CHB by large-scale population-based observational *** Among the patients with CHB enrolled in the Korean National Health Insurance Service between January 1,2009,and December 31,2017,those aged≥20 years who drank alcohol,smoked cigarettes,and were sedentary were *** included at least one LSM,including alcohol abstinence,smoking cessation,and regular *** primary outcome was HCC development,and the secondary outcome was liver-related *** used 2:1 propensity score matching to account for *** With 48766 patients in the LSM group and 103560 in the control group,the adjusted hazard ratio(HR)for incident HCC and liver-related mortality was 0.92[95%confidence interval(CI):0.87-0.96]and 0.92(95%CI:0.86-0.99)in the LSM group,respectively,compared with the control *** the LSM group,the adjusted HR(95%CI)for incident HCC was 0.84(0.76-0.94),0.87(0.81-0.94),and 1.08(1.00-1.16)for alcohol abstinence,smoking cessation,and regular exercise,*** adjusted HR(95%CI)for liver-related mortality was 0.92(0.80-1.06),0.81(0.72-0.91),and 1.15(1.04-1.27)for alcohol abstinence,smoking cessation,and regular exercise,*** LSM lowered the risk of HCC and mortality in patients with ***,active LSM,particularly alcohol abstinence and smoking cessation,should be encouraged in patients with CHB.

关键词： lifestyle modification Chronic hepatitis B Hepatocellular carcinoma Cancer Mortality

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Effects of lifestyle modification on liver enzyme and Fibroscan in Indian patients with non-alcoholic fatty liver disease

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Gastroenterology Report 2018年第1期6卷 49-53,I0002页

作者： Jayanta Paul Raj Vigna Venugopal Lorance Peter Shihaz Hussain Kula Naresh Kumar Shetty Mohit P.Shetti Department of Gastroenterology Manipal HospitalBangaloreIndia

Background and aims:Non-alcoholic fatty liver disease(NAFLD)is remarkably increasing in developing countries like India,in parallel with the increasing incidence of *** modification is a recommended treatment for *** most of the previous studies,improvement after lifestyle modification was assessed by liver fibrosis through liver biopsy,but we cannot do a serial liver biopsy in every NAFLD *** fibrosis can also be assessed by fibroscan non-invasively in *** study was designed to evaluate the effect of lifestyle modification on liver enzymes and Fibroscan values in a population with ***:Initially,50 NAFLD patients were included in this prospective follow-up study;however,after 6 months of lifestyle modification,only 39 participants were *** both the first and second consultations,Fibroscan was carried *** participants underwent a careful interview,anthropometry measurements and radiological and biochemical tests during every ***:After 6 months of lifestyle modification,Fibroscan values improved significantly(8.3160.11kPa vs 7.8760.12kPa,p¼0.009).Alanine aminotransferase(ALT)values also showed improvement during the second consultation(97.2562.62 U/L vs 66.6963.95 U/L,plifestyle modification is an effective therapy to downgrade hepatic injury in NAFLD *** Fibroscan can be used to assess the treatment response in NAFLD patients due to its non-invasive nature.

关键词： non-alcoholic fatty liver disease lifestyle modification alanine aminotransferase Fibroscan

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Factors Facilitating Adherence to Recommended lifestyle-modification amongst Hypertensive Clients at Malamulo Hospital, Thyolo, Malawi

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Journal of Biosciences and Medicines 2022年第5期10卷 191-205页

作者： Ndaona Chitani Mandayachepa Nyando Mary Miston Mbeba Edina Taziona N. Kholowa School of Nursing Adult Health Department Kamuzu University of Health Sciences Lilongwe Malawi Nursing and Midwifery Department Malamulo College of Health Sciences Malawi Adventist University Thyolo Malawi

Background: Adherence to recommended lifestyle modification regarding hypertension control remains a serious problem in Malawi, leading to poor blood pressure control. Objective: This study examined factors that facilitate adherence to recommended lifestyle modification among hypertensive clients’ at Malamulo hospital in Thyolo Malawi. Methods: A descriptive cross-sectional quantitative study was conducted with 108 clients who were recruited through a systematic sampling method. Data were collected through face-to-face interviews using a pre-tested structured questionnaire. Using statistical Packages for Social Sciences (SPSS) version 22, Chi-Square (x2) test was applied to test each predictor variable for statistical significance. The significant predictors were entered into the logistic regression model to determine the independent predictors of recommended lifestyle modifications amongst clients. Odds ratio (OR) at 95% Confidence Interval (CI) was used to declare the independent effect of each variable on the outcome variable. Results: 108 respondents were enrolled in the study, the majority of who were women (60.2%). Findings demonstrated that clients had adequate knowledge of lifestyle modification with an overall knowledge rate of 92% though the overall adherence rate was poor at 53.8%. Having family support (OR = 4.587, 95% CI: 1.625, 12.947, p = 0.004) and support groups (OR = 4.043, 95% CI: 1.496, 10.926, p = 0.006) are more likely to facilitate adherence to recommended lifestyle modification unlike situations of non-involvement of family and lack of support groups. Conclusion: Clients demonstrated adequate knowledge of recommended lifestyle modifications with poor adherence to them. The presence of support groups and a strong family support system are important factors for fostering adherence to the recommended lifestyle modifications regarding hypertension control.

关键词： Adherence lifestyle modification Hypertension Non-Communicable Diseases

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Effects of traditional Chinese medicine on symptoms of patients with spleen and stomach deficiency-related tinnitus

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World Journal of Clinical Cases 2024年第28期12卷 6165-6172页

作者： Na Cui Chen Zhao Jun-Lai Xue Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Traditional Chinese Medicine China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Tinnitus affects 10%-30%of the *** evidence suggests that tinnitus is associated with spleen ***,compared with kidney deficiency-related tinnitus,less research has been conducted on the impact of spleen defi-ciency-related *** To investigate the clinical efficacy of using Guipi Wan and dietary and lifestyle modification based on traditional Chinese medicine for treatment of patients with spleen and stomach deficiency-related *** We enrolled 110 patients with spleen and stomach deficiency-related tinnitus who were distributed into treatment(58 cases)and control(52 cases)*** severity,sleep quality and emotional state were assessed by questionnaires[Tinnitus Evaluation Questionnaire(TEQ);Pittsburgh Sleep Quality Index(PSQI);Depression-Anxiety-Stress Scale-21(DASS-21)]that were used for analysis in the two groups during the initial and intervention and *** the treatment group,patients were treated with oral administration of Guipi Wan and consulted for healthy dietary and lifestyle *** the control group,patients were only assessed and not *** At the end of the 6-months,TEQ scores decreased significantly in the treatment group(P=0.021)but not in the Control *** effects in the treatment group were noted for PSQI total score(P=0.043)and several PSQI component scores in the treatment group(Plifestyle modification based on regulating the spleen and stomach can be considered core to the treatment of tinnitus related to spleen and stomach deficiency.

关键词： Spleen and stomach deficiency-related tinnitus Traditional Chinese medicine Guipi Wan Dietary modification lifestyle modification

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Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 730-739页

作者： Pimsiri Sripongpun Chaitong Churuangsuk Chalermrat Bunchorntavakul Gastroenterology and Hepatology Unit Division of Internal MedicineFaculty of MedicinePrince of Songkla UniversityHat YaiThailand Nutrition and Obesity Management Unit Division of Internal MedicineFaculty of MedicinePrince of Songkla UniversityHat YaiThailand Division of Gastroenterology and Hepatology Department of MedicineRajavithi HospitalRangsit UniversityBangkokThailand

Nonalcoholic fatty liver disease (NAFLD) is emerging globally, while no therapeutic medication has been approved as an effective treatment to date, lifestyle intervention through dietary modification and physical exercise plays a critical role in NAFLD management. In terms of dietary modification, Mediterranean diet is the most studied dietary pattern and is recommended in many guidelines, however, it may not be feasible and affordable for many patients. Recently, a ketogenic diet and intermittent fasting have gained public attention and have been studied in the role of weight management. This article reviews specifically whether these trendy dietary patterns have an effect on NAFLD outcomes regarding intrahepatic fat content, fibrosis, and liver enzymes, the scientific rationales behind these particular dietary patterns, as well as the safety concerns in some certain patient groups.

关键词： Nonalcoholic fatty liver disease Ketogenic diet,Intermittent fasting lifestyle modification Weight reduction

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Upshots of health education among patients with type 2 diabetes mellitus: A field study in Mysuru

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Journal of Integrative Nursing 2023年第4期5卷 250-255页

作者： Deepak ANIL DSunil KUMAR Annaram RAVALI Vijaylakshmi Rao VADAGA Arun GOPI Department of Community Medicine JSS Medical CollegeJSS Academy of Higher Education and ResearchMysoreKarnatakaIndia

Objective:This study was conducted to assess the impact of health education on lifestyle modification and disease status of diabetic patients for 6 months in rural Mysuru in Southern *** and Methods:A quasi-experimental study was conducted among 104 patients with type 2 diabetes mellitus in rural Mysuru,India from July to December *** were assigned to two groups:intervention(n=52)and control(n=52),and their data were *** intervention group was educated about the disease and its management and was given printed pamphlets containing information to be followed,whereas the participants in the control group were asked to continue their routine health *** body mass index(BMI),weight,fasting blood sugar(FBS),knowledge about the disease,and behavior changes were recorded and compared between the two groups before and after 6 ***:The mean FBS value,BMI and weight decreased significantly in the intervention group after 6 months(FBS:164.79±47.59 mg/dL vs.141.92±25.63 mg/dL,P<0.001;BMI:22.97±3.75 kg/m2 vs.22.62±3.29 kg/m2,P<0.05;weight:62.82±11.92 kg vs.61.54±10.67 kg,P<0.05).The posttest period also showed an improvement in physical activity,diet,and medication adherence in the intervention group compared to the control group(P<0.05).The knowledge scores also improved postintervention which was statistically significant with the Wilcoxon signed-rank test(P<0.05).Conclusions:The effectiveness of the educational intervention was also supported by lower FBS levels and decrease in BMI and weight compared to *** findings of this study may help and make it easier to plan studies on people with diabetes mellitus in various settings.

关键词： Behavioral changes body mass index diabetes mellitus fasting blood sugar health education lifestyle modification

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Management strategy of infertility in polycystic ovary syndrome

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Global Health Journal 2022年第2期6卷 70-74页

作者： Meng Li Xiangyan Ruan Alfred O.Mueck Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child.Health Care Hospital Yaojiayuan Road 251Beijing 100026China Department of Womens Health University Hospital Tuebingen Calwer Strasse 7Tuebingen 72076Germany

Polycystic ovary syndrome(PCOS)is the most common endocrine and metabolic disease in women of reproductive *** is characterized by ovulatory disruption,which can lead to *** with PCOS are also more likely to have poor pregnancy *** obese women,lifestyle interventions are recommended first,which have general health *** women who have difficulty changing their lifestyle,drugs for the treatment of obesity or bariatric surgery could be *** citrate is the first-line medication after weight loss that has been utilized in the *** is supplanting clomiphene as the best option for ovulation induction for now,particularly in patients with *** can improve ovulation and pregnancy rates;however,it has minimal effects in terms of raising live birth ***-line therapies include gonadotropins and laparoscopic ovary *** vitro fertilization can be utilized as a third-line treatment for patients with PCOS who have failed ovulation induction therapy or have other infertility *** summary,to achieve fertility,patients with PCOS require standardized individualized therapy.

关键词： Polycystic ovary syndrome Infertility lifestyle modification Ovulation induction

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