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lidocaine hydrochloride loaded isomaltulose microneedles for efficient local anesthesia of the skin

Chinese Chemical Letters 2024年第4期35卷 298-302页

作者： Xuebing Jiang Siyi Wang Li Zhang Xian Jiang Maling Gou State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China Huahang Microcreate Technology Co. Ltd.Chengdu 610042China Department of Dermatology West China HospitalSichuan UniversityChengdu 610041China

lidocaine hydrochloride(LIDH) as an anesthetic is widely used in local anesthesia. Dissolving microneedles(MNs) have great application value in the field of skin anesthesia. However, the limited drug-loading of dissolving MNs is an existing challenge that affects clinical use. In this study, we have screened isomaltulose(ISO) as the proper matrix material for the MNs by using molecular dynamics(MD) simulation. Our findings indicate that ISO has good compatibility with LIDH, and the LIDH-loaded ISO MNs(LI-MNs) have high drug-loading capacity. The drug-loading capacity of LI-MNs could reach 80%, and it could effectively puncture the skin. In addition, the preparation method of customized LI-MNs was established based on three-dimensional(3D) printing technology. It was shown that the administration time of LI-MNs could be controlled within 3 min. Also, the LI-MNs were able to provide the local anesthetic efficacy within2 min and sustained for more than 2 h. Significantly, LI-MNs had more efficient drug efficacy compared to the topical creams and the majority of existing LIDH-loaded dissolving MNs. They even provided a longer duration of action than the injections. Overall, the LI-MNs with high drug-loading have a promising application prospect.

关键词： Microneedles Local anesthesia lidocaine hydrochloride Isomaltulose Transdermal delivery

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Anterior cingulate cortex substitutes for the impaired retrieval role of prelimbic cortex in trace eyeblink conditioning

Anterior cingulate cortex substitutes for the impaired retri...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Guang-Yan WU~(1,2,3),Zheng-Li FAN~2,Xuan LI~2,Bing WU~2,Rui FAN~4,Jian-Feng SUI~(1,2,*) 1 Department of Physiology,College of Basic Medical Sciences,Third Military Medical University,Chongqing 400038, China 2 Experimental Center of Basic Medicine,College of Basic Medical Sciences,Third Military Medical University, Chongqing 400038,China 3 The Second Team of Cadet Brigade,Third Military Medical University,Chongqing 400038,China 4 Department of Rehabilitation,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010, China

＜正＞Objective It has been suggested that the anterior cingulate cortex（ACC） and prelimbic cortex（PL） of medial prefrontal cortex（mPFC） have critical roles in the acquisition and retrieval（expression） processes of trace eyeblink conditioning（TEC）,*** was also reported that re-training after PL lesions following initial learning could recover the impaired behavioral *** on these results,we hypothesized that ACC substituted for the impaired retrieval role of PL in *** present study is to investigate（1） the hypothesis of TEC retrieval substitution and（2） the natural roles of ACC and PL in *** lidocaine hydrochloride（LH） or saline was microinfused into ACC,or PL,or both ACC and PL after daily pre-infusion session training following 8 days initial acquisition ***（1） Infusion of lidocaine into area 24 does not significantly affect TEC expression.（2） Area 24 infusions affect TEC acquisition as evidenced by a difference in pre-infusion and post-infusion performance between sham and lesion groups that develops over several infusion days.（3） Area 32 infusions have immediate effect on TEC expression.（4） The expression deficits with area 32 infusions fades over 5 infusion sessions,and（5） subsequent dual infusions into both regions produces immediate deficits that do not *** The results support our hypothesis of substitution and also indicate that reversible inactivation of ACC prevented the acquisition of TEC but did not affect its retrieval,whereas reversible inactivation of PL caused significant deficits in retrieval of TEC,but did not affect its acquisition.

关键词： guinea pig lidocaine hydrochloride medial prefrontal cortex retrieval substitution reversible inactivation trace conditioning

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