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Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

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Neural Regeneration Research 2019年第4期14卷 666-672页

作者： Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul Driss Boussaoud Laboratory of Clinical Neuroscience Faculty of Medicine Department of Neurosurgery University Hospital of Fez Laboratory of Neuroendocrinology and Nutritional and Climatic Environment Faculty of Sciences Dhar El Mahraz Department of Biophysics and Clinical MRI Methods Faculty of Medicine Department of Radiology and Clinical Imaging University Hospital of Fez Department of Psychiatry University Hospital of Fez Aix Marseille Université INSERM INS Institut de Neurosciences des Systèmes

Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease.

关键词： Parkinson’s disease emotion processing Blood oxygenation level-dependent functional magnetic resonance imaging brain activation dopamine neural regeneration

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Alteration of functional connectivity in patients with Alzheimer’s disease revealed by resting-state functional magnetic resonance imaging

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Neural Regeneration Research 2020年第2期15卷 285-292页

作者： Jie Zhao Yu-Hang Du Xue-Tong Ding Xue-Hu Wang Guo-Zun Men School of Electronic and Information Engineering Hebei UniversityBaodingHebei ProvinceChina Research Center of Machine Vision Engineering & Technology of Hebei Province BaodingHebei ProvinceChina Key Laboratory of Digital Medical Engineering of Hebei Province BaodingHebei ProvinceChina School of Economics Hebei UniversityBaodingHebei ProvinceChina

The main symptom of patients with Alzheimer’s disease is cognitive dysfunction. Alzheimer’s disease is mainly diagnosed based on changes in brain structure. Functional connectivity reflects the synchrony of functional activities between non-adjacent brain regions, and changes in functional connectivity appear earlier than those in brain structure. In this study, we detected resting-state functional connectivity changes in patients with Alzheimer’s disease to provide reference evidence for disease prediction. Functional magnetic resonance imaging data from patients with Alzheimer’s disease were used to show whether particular white and gray matter areas had certain functional connectivity patterns and if these patterns changed with disease severity. In nine white and corresponding gray matter regions, correlations of normal cognition, early mild cognitive impairment, and late mild cognitive impairment with blood oxygen level-dependent signal time series were detected. Average correlation coefficient analysis indicated functional connectivity patterns between white and gray matter in the resting state of patients with Alzheimer’s disease. Functional connectivity pattern variation correlated with disease severity, with some regions having relatively strong or weak correlations. We found that the correlation coefficients of five regions were 0.3–0.5 in patients with normal cognition and 0–0.2 in those developing Alzheimer’s disease. Moreover, in the other four regions, the range increased to 0.45–0.7 with increasing cognitive impairment. In some white and gray matter areas, there were specific connectivity patterns. Changes in regional white and gray matter connectivity patterns may be used to predict Alzheimer’s disease;however, detailed information on specific connectivity patterns is needed. All study data were obtained from the Alzheimer’s Disease Neuroimaging Initiative Library of the Image and Data Archive Database.

关键词： Alzheimer's disease blood oxygen level-dependent signal correlation coefficient functional connectivity pattern functional magnetic resonance imaging gray matter resting state white matter

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Morphological and functional evaluation of chronic kidney disease using magnetic resonance imaging

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World Journal of Clinical Urology 2014年第3期3卷 325-329页

作者： Tsutomu Inoue Eito Kozawa Hirokazu Okada Hiromichi Suzuki Department of Nephrology Faculty of Medicine Saitama Medical UniversitySaitama 350-0495 Japan Department of Diagnostic Radiology Saitama Medical University International Medical CenterSaitama 350-1298 Japan

X-ray computed tomography(CT),ultrasonography(US)and radionuclide scanning are important clinical methods for evaluating morphology of the *** modalities are also applicable for estimating kidney function with time lapse analysis using proper contrastmedia as may be *** the case of US,it can estimate kidney function based on the measurement of blood flow using the Doppler ***,magnetic resonance imaging(MRI)was an inappropriate diagnostic imaging technique for abdominal organs because of their respiratory ***,MRI is now actively used for kidney as well as liver or other parenchymal organs,in tandem with the technological *** unenhanced X-ray CT,"conventional"MRI can distinguish the border between cortex and medulla in T1 or T2 weighted *** was known that the border blurred with decreasing kidney ***,several other particular imaging methods were introduced in recent years,and these could be called"functional"*** this review,the following are discussed:functional MRI for chronic kidney disease,which include blood oxygenation level-dependent MRI for evaluation of hypoxia,diffusion-weighted imagingfor evaluation of fibrosis,diffusion tensor imaging for evaluation of microstructure,and arterial spin labeling to evaluate the amount of organ perfusion,accompanied with several related *** ultimate goal of functional MRI is to provide useful in vivo information repeatedly for daily medical treatment non-invasively.

关键词： Magnetic resonance imaging Chronic kidney disease Blood oxygenation level-dependent effect Diffusion-weighted imaging Diffusion tensor imaging Arterial spin labeling Fibrosis Hypoxia Functional magnetic resonance imaging

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