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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3343-3349页

作者： Chun-Yan Niu Bang-Tao Yao Hua-Yi Tao Xin-Gui Peng Qing-Hua Zhang Yue Chen Lu Liu Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Department of Ophthalmology Nanjing Lishui People’s HospitalNanjing 211200Jiangsu ProvinceChina Department of Medical Imaging Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Thrombocytopenia is a common complication of invasive liver abscess syndrome(ILAS)by Klebsiella pneumoniae(***)infection,which indicates severe infection and a poor ***,the presence of leukopenia is *** are rare reports on leukopenia and its clinical significance for ILAS,and there is currently no recognized treatment *** and broad-spectrum antimi-crobial therapy may be an effective therapy for treating ILAS and improving its *** SUMMARY A 55-year-old male patient who developed fever,chills,and abdominal distension without an obvious cause presented to the hospital for *** tests revealed thrombocytopenia,leukopenia,and multiple organ *** examinations revealed an abscess in the right lobe of the liver and thromboph-lebitis,and *** was detected in the blood *** the patient was diabetic and had multi-system involvement,he was diagnosed with ILAS accom-panied by leukopenia and *** antibiotic treatment and sys-temic supportive therapy,the symptoms disappeared,and the patient’s condition almost completely *** leukopenia is a rare complication of ILAS,which serves as an indicator of adverse prognostic outcomes and the severity of infection.

关键词： Invasive liver abscess syndrome Klebsiella pneumoniae leukopenia Thrombocytopenia Treatment Prognosis Case report

Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients

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World Journal of Gastroenterology 2019年第38期25卷 5850-5861页

作者： Xia Zhu Kang Chao Miao Li Wen Xie Hong Zheng Jin-Xin Zhang Pin-Jin Hu Min Huang Xiang Gao Xue-Ding Wang Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Gastroenterology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States School of Public Health Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian *** nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this *** potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been *** we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C *** Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February ***15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were *** A total of 411 Crohn’s disease patients were *** was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 *** CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 *** 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,*** The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C *** 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.

关键词： Crohn’s disease Thioguanine nucleotide levels Nucleoside diphosphatelinked moiety X-type motif 15 Thiopurine-induced leukopenia

Prognostic value of chemotherapy-induced leukopenia in small-cell lung cancer

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Cancer Biology & Medicine 2013年第2期10卷 92-98页

作者： Wei Liu Cui-Cui Zhang Kai Li Department of Thoracic Oncology Key Laboratory of Cancer Prevention and Treatment of Tianjin City Tianjin Lung Cancer Center Tianjin Medical University Cancer Institute and Hospital

Objective: Chemotherapy is the standard treatment for small-cell lung cancer (SCLC), and leukopenia is a common side effect. This study assesses whether chemotherapy-induced leukopenia is a predictor of efficacy and whether it is associated with the survival of SCLC patients. Methods: A retrospective analysis was conducted on data from 445 patients with SCLC who received standard chemotherapy for 4 to 10 cycles. The World Health Organization grading system classifies leukopenia during chemotherapy as follows: absent (grade 0), mild (grades 1 and 2), or severe (grades 3 and 4). The primary endpoint is overall survival (OS). Results: The association between chemotherapy-induced leukopenia and OS was assessed. According to a multivariate Cox model with time-varying covariates, the hazard ratio of death was significantly lower among patients with mild leukopenia than among patients with severe leukopenia at 0.687 (0.506 to 0.943) and 1.414 (1.147 to 1.744), respectively. The median survival was 13 months (95% CI: 11 to 15 months) for patients who did not experience leukopenia, 17 months (95% CI: 14 to 18 months) for those with mild leukopenia, and 14 months (95% CI: 13 to 16 months) for those with severe leukopenia (absent vs. mild vs. severe leukopenia, P=0.047). Conclusion: leukopenia during chemotherapy is associated with the survival of SCLC patients. Mild leukopenia is strongly associated with longer survival time.

关键词： Small-cell lung cancer (SCLC) leukopenia prognosis

Analysis of the Therapeutic Effect of Sodium Copper Chlorophyllin Tablet in Treating60Cases of leukopenia

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Chinese Journal of Integrated Traditional and Western Medicine 2005年第4期11卷 279-282页

作者：高峰胡秀芬 Depart ment of Internal Medicine Union Hospital ofTongji Medical College Huazhong University of Science andTechnology Wuhan 430022 Depart ment of Pediat-rics Tongji Hospital of Tongji Medical College HuazhongUniversity of Science and Technology

Objective： To evaluate the efficacy and safety of sodium copper chlorophyllin （trademarked as ＂Yebaike Tablet （叶拜克） which is abbreviated as YBK in treating leukopenia. Methods： One hundred and five patients with leukopenia caused by various factors were randomized into 3 groups. The 60 patients in the YBK group took orally YBK Tablets at the dose of 40 mg, three times per day, the 30 patients in the leucogen group were treated with Leucogen Tablets （利血生片） at the dose of 20 mg, three times per day, and the 15 patients in the placebo group were administered with vitamin C tablets 100 mg, three times per day. All the subjects were treated for 1 month. The change of peripheral leucocytes count after treatment and adverse drug reaction that occurred in patients were studied. Results： In the 60 patients treated with YBK, the treatment proved to be markedly effective in 34 cases, effective in 17 and ineffective in 9, the total effective rate being 85%, which was significantly higher than that in the placebo group （26.7%, P〈0.01） and similar to that in the leucogen group （83.3 %, P〉0.05）. No adverse reaction was found in the treatment course. Conclusion： YBK can be used in the treatment of leukopenia caused by various factors, satisfactory in efficacy and safe in use.

关键词： leukopenia sodium copper chlorophyllin

CLINICAL OBSERVATION ON THERAPEUTIC EFFECT OF ACUPUNCTURE AT ZUSANLI FOR leukopenia

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Journal of Traditional Chinese Medicine 1998年第2期18卷 94-95页

作者：魏赞美 324 Central Hospital of the People's Liberation Army Chongqing.

In recent years, leukopenia is clinically very common. The leukopenic patient is significantly low in immunocompetence and is likely to suffer from various kinds of infections. Zusanli (St 36), an

关键词： Acupuncture Points Acupuncture Therapy Adult Aged Arthritis, Rheumatoid Female Humans Hypersplenism Immunoglobulin G leukopenia Lung Neoplasms Male Middle Aged

Treatment of 104 Cases of Chemotherapy-Induced leukopenia by Injection of Drugs into Zusanli

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Journal of Traditional Chinese Medicine 2001年第1期21卷 27-28页

作者：尹先哲尹德印刘新群丁旭萌周永生 The Second People's Hospital of Nanyang City Nanyang 473012 Henan Province

From April 1992 to April 1998, 104 cases of chemotherapy-induced leukopenia were treated by injection into Zusanli (ST 36) with a mixture consisting of dexamethasone, 654-2, ATP and inosine. The therapeutic results were satisfactory as reported in the following.Clinical Data In this series, all the 127 cases were definitely diagnosed by pathological examination. Of them, 93 were male and 34 female, ranging in age from 12 to 75 years. 38 cases were carcinoma of esophagus, 22 carcinoma of cardia of stomach, 21 cancer of lung, 11 hepatic carcinoma, 8 lymphoma, 8 mammary cancer, 7 carcinoma of colon, and 12 other kinds of the tumors. Leukocyte count was below 4.0×109/L in all the patients after being treated by chemotherapy.

关键词： Acupuncture Points Adenosine Triphosphate Adolescent Adult Aged Antineoplastic Agents Carcinoma, Squamous Cell Child Dexamethasone Esophageal Neoplasms Female Humans Injections Inosine leukopenia Male Middle Aged Solanaceous Alkaloids Stomach Neoplasms

Risk factors for leukopenia in patients with gastrointestinal fistula

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Chinese Medical Journal 2010年第23期123卷 3433-3437页

作者： ZHOU Zheng REN Jian-an LIU Hai-yan GU Guo-sheng LI Jie-shou The Research Institute of General Surgery Jinling HospitalMedical School of Nanjing University Nanjing Jiangsu 210093China Intensive Care Unit First Affiliated Hospital of Anhui MedicalUniversity Hefei Anhui 230022 China

Background White blood cell count is an important index to the outcome of patients. In hospital, leukopenia is accompanied by high mortality, morbidity and treatment costs. However, in infectious diseases, the reasons responsible for leucopenia was not well elucidated. We investigated patients with gastrointestinal fistula to find risk factors for *** A prospective case control investigation was carried out in the Gastrointestinal Fistula Center, General Surgical Institute of Jinling Hospital. Cases included gastrointestinal fistula patients with leukopenia （n=98） and controls composed of gastrointestinal fistula patients with normal white blood cell count （n=78）. The two groups were compared for risk factors of leucopenia by statistical *** Factors associated with an increased risk for leukopenia included bacterial infection （25.5%） and hypoalbuminaemia （61.2%）. Multivariable Logistic regression analysis identified bacterial infection （80%）, urinary catheter （70%） and central vein catheter （60%） as the independent determinants for mortality in *** In patients with gastrointestinal fistula, two independent factors for leukopenia and three significant predictors of mortality were elucidated. We suggest that clinicians give patients more supportive management and apply prevention strategies to treat and prevent leukopenia.

关键词： risk factors leukopenia gastrointestinal fistula

Regulatory Effect of Acupuncture and Moxibustion on the Hematopoiesis of leukopenia Model in Rats

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Journal of Acupuncture and Tuina Science 2006年第2期4卷 75-78页

作者：崔瑾申定珠熊芳丽朱忠春(译) Acupuncture-massotherapy Department First Hospital Affiliated to Guiyang College of Traditional Chinese Medicine Guizhou 550001 P. R China Xiangya Medical College of Zhongnan University Changsha 410013 P. R. China 不详

Objective. To investigate the effect of acupuncture or moxibustion at acupoint Geshu （BL 17） on raising leukocyte and promoting marrow proliferation. Methods.. Wister rats were selected to establish the leukopenia and immuno-suppression model by intraperitoneal injection of cytoxan （CTX）. After they were grouped and treated, leukocyte and marrow karyocyte were counted in different phases to evaluate the effect of acupuncture or moxibustion at acupoint Geshu （BL 17） on raising leukocyte and promoting marrow hematopoiesis. Results. Acupuncture or moxibustion at acupoint Geshu （BL 17） and routine western medicine could all significantly raise leukocyte and increase marrow karyocyte. The curative effect was better in moxibustion group than in acupuncture group and in routine western medicine group （P〈 0.05）. Conclusion. Moxibustion at acupoint Geshu （BL 17） can markedly raise peripheral blood leukocyte and marrow karyocyte of the leucopenia model in rats.

关键词： Point BL17 Cytoxan leukopenia Marrow Karyocyte Count

Observations on Curative Effect of Point Injection on Postchemotherapeutic leukopenia

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Journal of Acupuncture and Tuina Science 2005年第5期3卷 41-43页

作者：杜昭琳孙迎红康红梅程建玲 Tumor Research and Treatment Center Shandong Province Hospital Ji'nan 250000 China

Objective： To investigate the effect of point injection on post-chemotherapeutic leukopenia. Methods： Three hundred patients were randomly divided into two groups. In the treatment group, 0.6 ml granulocyte colony stimulating factor was injected into bilateral Xuehai （SP 10） and in the control group, the same dose subcutaneously into the deltoid muscle in the upper arm, once daily, three consecutive times as a course of treatment. A peripheral leukocyte count was examined at 3rd, 5th and 7th day after injection. Results and Conclusion： Under three courses of chemotherapy, therewas no significant difference in leukocyte increase between the two methods at 3rd and 5th day after treatment but a leukocyte count was significantly higher at 7th day in the treatment group than in the control group （P〈0.05）. After over half courses of chemotherapy, a peripheral leukocyte count was significantly higher in the treatment group than in the control group （P〈0.05） and it did not rise to the normal at 5-7 days after treatment in the control group. It is showed that point injection raised leukocyte quickly and kept the effect long in comparison with subcutaneous injection and the adverse responses were significantly less in the treatment group than in the control group.

关键词： Point injection leukopenia Tumor Chemotherapy

Acupoint Injection plus Moxibustion on Post-chemotherapy leukopenia

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Journal of Acupuncture and Tuina Science 2006年第2期4卷 87-89页

作者：刘萍刘艳唐强邵命海 Rehabilitation Center Second People's Hospital of DalianLiaoning 116011P.R.China Clinical Library First Affiliated Hospital of Dalian Medical UniversityLiaoning 116000P.R.China Affiliated Hospital of Heilongjiang University of TCM Heilongjiang 150000P.R.China

Objective： to investigate the effect moxibustion on white blood cell amount and of Radi.r Astragali （黄芪） Injection and cellular immunity in patients with postchemotherapy leukopenia. Methods： eighty-six cases of post chemotherpy leucopenia were allocated into group of acupoint injection with Radix Astragali （黄芪） plus mild moxibustion with moxa stick（treatment group） and group of westerm medicine orally took（control group）, and the clinical symptoms, white blood cell amount, and the change of CD3^＋ , CD4^＋ and CD8^＋ before and after the treatment were observed. Results. acupoint injection with Radicc Astragali（黄芪） plus mild moxibustion with moxa stick could enhance the white blood cell amount more markedly than western medicine. The former could increase the contents of CD3^＋ and CD2^＋, and promote the ratio of CD4^＋ /CD^＋ of the patients with tumor, meanwhile, improve the general weak, and there is a significant different between the two groups（P〈 0.01）.

关键词： leukopenia Hydro-acupuncture Acupuncture-Moxibustion Moxa Stick Moxibustion