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Sishengtang decoction in alleviation of toxic and side effects of transarterial embolization

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World Journal of Gastroenterology 1998年第2期4卷 79-81页

作者： Chen, Z Ling, CQ Huang, XQ Zhang, HW Second Mil Med Univ Changhai Hosp Dept Tradit Chinese Med Shanghai 200433 Peoples R China

AIM To observe the therapeutic effects of Sishengtang decoction in alleviating the toxic and side effects of transarterial embolization (TAE). METHODS Fifty four patients with liver cancer were divided randomly into Sishengtang decoction group (34 cases) and control group (20 cases). The changes of clinical symptoms and peripheral hemogram and some cellular immune functions were observed before and two weeks after TAE. RESULTS Sishengtang decoction was superior to the control group in improving the digestive tract reaction. The leucocytes of peripheral blood and cellular immune functions (activities of NK cells and LAK cells) of control group decreased obviously after TAE, while that of Sishengtang decoction group decreased slightly, without obvious difference as compared with that of preoperation. CONCLUSIONS Sishengtang decoction might improve the clinical symptoms and increase the leucocytes of peripheral blood and the cellular immune functions of TAE patients.

关键词： Sishengtang decoction liver neoplasms/therapy embolization, therapeutic immunity , cellular killer cell, natural killer cell , lymphokine activated leucocytes

The impact of alloantibodies directed against the second donor on long-term outcomes of repeat liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 246-252页

作者： Qingyong Xu Brad Shrum Steve Leckie Anton Skaro Vivian C.McAlister Department of Pathology and Lab Medicine University of Western OntarioLondonONCanada Department of Surgery University of Western OntarioLondonONCanada

Background:Despite reports that associate donor specific antibody(DSA)with rejection after liver transplantation,grafts are still allocated according to blood group(ABO)but not human leukocyte antigen(HLA)compatibility,possibly due to the absence of an easily discernible clinical association between adverse recipient outcome and ***-transplantation provides a test environment where the presence of preformed DSA is prevalent and its effect on outcome should be ***:All patients undergoing a second liver transplantation with available pre-operative serum were included with the exception of ABO incompatible or multiple organ *** sera were tested for anti-HLA antibodies with Luminex-based solid phase ***-HLA antibodies to the second donor(D2SA)were determined using antibodies specificity and HLA typing of 2nd liver ***:Preformed HLA antibodies directed to second liver transplantation(D2SA)were found in 31(39%)of the 79 patients that were included in the *** and re-transplantation characteristics were similar in both subgroups except first graft survival which was significantly shorter in recipients who are negative for *** survival of the second graft was similar in D2SA+and D2SA?cohorts[8.55(range,0.01–24.74)vs.7.56(range,0–23.53)years respectively,P=0.574].Mean patient survival after 2nd liver transplantation was similar in D2SA+and D2SA?cohorts[9.11(range,0.01–24.74)vs.8.10(range,0–23.53)years respectively,P=0.504].Subgroup univariate analysis demonstrated no detrimental effect of class,locus,or strength of D2SA on survival of the second liver *** multivariate cox regression model,neither class I D2DSA(HR=1.101,P=0.92)nor class II D2SA(HR=1.74,P=0.359)were significant risks of graft ***:Presence of D2SA was not found to be associated with inferior outcomes in this retrospective cohort study of liver re-transplantation suggesting that changes to the allocation system are not requ

关键词： Donor-specific antibodies(DSA) human leucocytes antigen(HLA) liver transplantation

Studies on the mechanisms of anti-inflammatory activity of the extracts and fractions of Alchornea floribunda leaves

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 7-14页

作者： Festus BC Okoye Patience O.Osadebe Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical SciencesUniversity of NigeriaNsukka410001Enugu StateNigeria

Objective:Alchornea floribunda leaves are widely used in ethnomedicinal management of inflammatory disorders. The present work is aimed at investigating this folkloric ***:The anti-inflammatory effect of the leaf extracts and fractions was investigated in experimental animal models of acute and chronic inflammation. The possible mechanisms by which the two most active fractions,hexane(HE) and ethyl acetate(EF) exert their effects were also ***:The crude extract(200 mg/kg) showed moderate inhibition of egg albumen-induced edema in rats(%edema inhibition = 54.69) at 4 *** and EF showed very high activity(%edema inhibition of 81.25 and 67.19 respectively at 200 mg/kg) at 4h as compared to the control. Both fractions ameliorated arthritis induced by formaldehyde in *** 400 mg/kg,HE evofeed a significant irritation of gastric mucosa in ***(200 mg/kg,p.o.) significantly inhibited leucocytes(%inhibition = 36.79) migration in vivo,but could not stabilize heat and hypotonicity-indueed lysis of human erythrocyte at 200 and 400μg/mL in *** investigation revealed the presence of terpenoids and steroids in HE and flavonoids,tannins and saponins in ***:These results suggest that the leaves of Alchornea floribunda possess anti-inflammatory activity in acute and chronic *** activity may derive from a combination of inhibition of prostaglandin synthesis and leucocytes *** phytochemical constituents detected in HE and EF may account for the anti-inflammatory activity.

关键词： Alchornea floribunda Anti-inflammatory Arthritis leucocytes migration Membrane stabilization Plant extracts

Efficacy of boswellic acid on lysosomal acid hydrolases,lipid peroxidation and anti-oxidant status in gouty arthritic mice

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 128-133页

作者： Evan Prince Sabina Haridas Indu Mahaboobkhan Rasool School of Bio Sciences and Technology VIT University Vellore-632 014

Objective:To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in ***:The mice were divided into four experimental ***Ⅰserved as control;mice in groupⅡwere injected with monosodium urate crystal;groupⅢconsisted of monosodium urate crystal-induced mice who were treated with boswellic acid(30mg/kg/b.w.);groupⅣcomprised monosodium urate crystal-induced mice who were treated with indomethacin(3mg/kg/b.w.).Paw volume and levels/activities of lysosomal enzymes,lipid peroxidation,anti-oxidant status and inflammatory mediator TNF-αwere determined in control and monosodium urate crystal-induced *** addition,the levels ofβ-glucuronidase and lactate dehydrogenase were also measured in monosodium urate crystal-incubated polymorphonuclear leucocytes(PMNL)in ***:The activities of lysosomal enzymes,lipid peroxidation,and tumour necrosis factor-αlevels and paw volume were increased significantly in monosodium urate crystal-induced mice,whereas the activities of antioxidant status were in turn ***,these changes were modulated to near normal levels upon boswellic acid *** vitro,boswellic acid reduced the level ofβ-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated PMNL in concentration dependent manner when compared with control ***:The results obtained in this study further strengthen the anti-inflammatory/antiarthritic effect of boswellic acid,which was already well established by several investigators.

关键词： Boswellic acid Gouty arthritis Indomethacin Lysosomal enzymes Polymorphonuclear leucocytes Monosodium urate Lipid peroxidation Antioxidant status Anti-inflammatory effect Antiarthritic effect Inflammation