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Synthetic aperture-based on-chip microscopy

Light(Science & Applications) 2015年第1期4卷 438-446页

作者： Wei Luo Alon Greenbaum Yibo Zhang Aydogan Ozcan Electrical Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Wide field-of-view(FOV)and high-resolution imaging requires microscopy modalities to have large space-bandwidth *** on-chip microscopy decouples resolution from FOV and can achieve a space-bandwidth product greater than one billion under unit magnification using state-of-the-art opto-electronic sensor chips and pixel super-resolution ***,using vertical illumination,the effective numerical aperture(NA)that can be achieved with an on-chip microscope is limited by a poor signal-to-noise ratio(SNR)at high spatial frequencies and imaging artifacts that arise as a result of the relatively narrow acceptance angles of the sensor’s ***,we report,for the first time,a synthetic aperture-based on-chip microscope in which the illumination angle is scanned across the surface of a dome to increase the effective NA of the reconstructed lensfree image to 1.4,achieving e.g.,,250-nm resolution at 700-nm wavelength under unit *** synthetic aperture approach not only represents the largest NA achieved to date using an on-chip microscope but also enables color imaging of connected tissue samples,such as pathology slides,by achieving robust phase recovery without the need for multi-height scanning or any prior information about the *** validate the effectiveness of this synthetic aperture-based,partially coherent,holographic on-chip microscope,we have successfully imaged color-stained cancer tissue slides as well as unstained Papanicolaou smears across a very large FOV of 20.5 mm^(2).This compact on-chip microscope based on a synthetic aperture approach could be useful for various applications in medicine,physical sciences and engineering that demand high-resolution wide-field imaging.

关键词： computational imaging lensfree microscopy on-chip microscopy synthetic aperture

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