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Microglia and astroglia:the role of neuroinflammation in lead toxicity and neuronal injury in the brain

Neuroimmunology and Neuroinflammation 2015年第1期2卷 131-137页

作者： Jin-Tao Liu Mo-Han Dong Jie-Qiong Zhang Ya Bai Fang Kuang Liang-Wei Chen Institute of Neurosciences The Fourth Military Medical UniversityXi’an 710032ShaanxiChina Department of Neurosurgery Tangdu HospitalThe Fourth Military Medical UniversityXi’an 710032ShaanxiChina School of Military Preventive Medicine The Fourth Military Medical UniversityXi’an 710032ShaanxiChina Department of Neurology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032ShaanxiChina

lead(Pb^(2+)),a ubiquitous environmental toxicant,may widely affect the function of many organs or systems of human beings,especially the *** lead is believed to transport into the brain through the blood-brain barrier(BBB)and cause direct neuronal injury,growing data have shown that lead exposure could induce brain dysfunction by triggering microglial and astroglial activation,pro-inflammatory cytokine production and inflammatory response,generation of reactive oxygen species and oxidative stress,and finally result in BBB dysfunction and neuronal *** review summarizes recent studies regarding microglial and astroglial reaction,neuroinflammation,and neuronal death in the brain following lead insult,suggesting that reactive glial cells may represent a potential target for manipulation of lead-induced neuroinflammatory injury of the brain.

关键词： Astroglia brain lead toxicity microglia neuroinflammation

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Effect of acetate on lead toxicity to microbial biomass in a red soil

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Journal of Environmental Sciences 1999年第1期11卷 90-96页

作者： K. S. Khan, Huang Chang yong College of Natural Resources and Environmental Sciences, Zhejiang Agricultural University, Hangzhou 310029, China

A laboratory incubation experiment was conducted to elucidate the effect of acetate on lead bioavailability and toxicity to microbial biomass in a red soil. Results indicated that the application of acetate along or at the lower lead levels of 100 and 200 μg/g soil stimulated the soil microbial biomass. The addition of acetate at the higher lead levels of 300, 450 and 600 μg/g soil caused significantly greater reductions in the biomass carbon(C mic ) and the biomass nitrogen (N mic ), compared with the control or the same lead levels applied individually. A greater increase in the biomass C:N ratio occurred by acetate addition at the same lead levels. The concentration of 0.01 mol/L CaCl 2 extractable lead was considerably higher in the lead plus acetate treatments than at the same lead levels with no acetate. Based on these results, it was concluded that the application of acetate might have suppressed the lead adsorption in the soil which in turn resulted in its more bioavailability and hence more toxicity to the soil microbial biomass.

关键词： acetate lead toxicity microbial biomass red soil.

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EXPERIMENTAL STUDY ON MECHANISMS OF EMBRYONIC toxicity OF lead NITRATE

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山东第一医科大学(山东省医学科学院)学报 1994年第1期 49-54页

作者： Yu Kai Tong Suming (Dept. of Histoembryology, Taishan Medical College)(Department of Histoembryology,Shanghai Medical College,Shanghai)

ＥＸＰＥＲＩＭＥＮＴＡＬＳＴＵＤＹＯＮＭＥＣＨＡＮＩＳＭＳＯＦＥＭＢＲＹＯＮＩＣＴＯＸＩＣＩＴＹＯＦＬＥＡＤＮＩＴＲＡＴＥ￥ＹｕＫａｉ（喻凯）；ＴｏｎｇＳｕｍｉｎｇ（童夙明）；（Ｄｅｐｔ．ｏｆＨｉｓｔｏｅｍｂｒｙｏｌ... 详细信息

ＥＸＰＥＲＩＭＥＮＴＡＬＳＴＵＤＹＯＮＭＥＣＨＡＮＩＳＭＳＯＦＥＭＢＲＹＯＮＩＣＴＯＸＩＣＩＴＹＯＦＬＥＡＤＮＩＴＲＡＴＥ￥ＹｕＫａｉ（喻凯）；ＴｏｎｇＳｕｍｉｎｇ（童夙明）；（Ｄｅｐｔ．ｏｆＨｉｓｔｏｅｍｂｒｙｏｌｏｇｙ，ＴａｉｓｈａｎＭｅｄｉｃａ...

关键词： lead toxicity placenta corpus luteum pituitary rat embryo

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lead chemisorption:Paving the last step for industrial perovskite solar cells

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Nano Research Energy 2024年第1期3卷 5-9页

作者： Pengfei Wu Jin Hyuck Heo Fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Department of Chemical and Biological Engineering Korea University145 Anam-RoSeongbuk-GuSeoul 17104Republic of Korea

Perovskite solar cells(PSCs)have exhibited impressive performance,achieving a power conversion efficiency(PCE)of 26.1%.However,the water-soluble and toxic nature of lead(Pb)in PSCs hinders their *** chemisorption has emerged as a promising approach to address this issue to prevent Pb leakage and ensure long-term *** perspective provides a comprehensive overview of recent advancements in Pb chemisorption in PSCs and discusses the prospects for future developments and challenges in this field.

关键词： perovskite solar cells lead toxicity chemisorption

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