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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Qiang GU,Bang-An WANG,Meng-Ya WANG~* Cell electrophysiology Laboratory,Wannan Medical College,Wuhu 241002,China

＜正＞Objective latent inhibition（LI） denotes that a prestimulus with repeated presentation but without reinforcement（***-expose） will interfere with the subsequent learning task related with this stimulation and its change is one important manifestation of *** work aims to explore whether behavioral training of reversal learning could interfere with LI of adult *** Twenty adult male Sprague-Dawley rats（body weights;100 - 120 g each） were randomly divided into two groups,pre-expose group（PE） and non pre-expose group （NPE）.The experimental protocol includes 3 stages:First,Gemini avoid system was used to observe LI phenomenon of rats,in which the number of active avoidance,no response,and avoiding latency were detected by the *** LI test procedvire contained adaptation phase,pre-expose phase,and conditioning ***,the followed intervention training of reversal learning was conducted in the Habitest radial-arm maze system（8 arms）.The process included adaptation phase,acquisition phase,and reversal learning phase,in which correct percent of running into arms of rats were ***,after the training of reversal learning,LI was tested in the same approach once *** （1） In the first LI test,the difference of no response number,and the avoiding latency was statistically significant（two-sample t test,P＜0.05） between the PE and NPE groups,while the difference in the number of active avoidance was not significant（P＞0.05）.These results mean that PE group shows latent inhibition.（2） In the intervention training of radial-arm maze,the difference in correct percentage of running into arms in two groups at the final day of acquisition phase（A8 day） and the first day of reversal learning phase（Rl day） was significant,respectively（paired Mest,P＜0.001）,indicating the occurrence of the reversal learning.（3） In the second LI test,the number of active avoidances or no responses,and avoiding latency did not differ between rats in the P

关键词： latent inhibition reversal learning schizophrenia

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Adolescent social isolation influences cognitive function in adult rats

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Neural Regeneration Research 2013年第11期8卷 1025-1030页

作者： Feng Shao Xiao Han Shuang Shao Weiwen Wang Department of Psychology Peking University Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation （isolated housing, 38-51 days of age） and social groups. latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.

关键词： neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophicfactor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmentaldisorders grants-supported paper neuroregeneration

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