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Chronic salt-loading downregulates large-conductance Ca^(2+)-activated potassium channel in mesenteric arterial smooth muscle cells from SD rats

引用

Journal of Pharmaceutical Analysis 2009年第4期21卷 215-221页

作者： Zhao-xia Zhou,Chao-feng Sun,Ai-qun Ma,Fang-yuan Chen,Na Wei,Fu-qiang Liu Department of Cardiovascular Medicine,the First Affiliated Hospital,Medical School of Xi’an Jiaotong University Institute of Cardiovascular channelopathy,Key Laboratory of Environment and Genes Related to Diseases(Xi’an Jiaotong University),Ministry of Education,Xi’an 710061,China DepartmentofCardiovascularMedicine theFirstAffiliatedHospitalMedicalSchoolofXi'anJiaotongUniversity InstituteofCardiovascularchannelopath KeyLaboratoryofEnvironmentandGenesRelatedtoDiseasesMinistryofEducationXi'an710061

Objective large-conductance calcium-activated potassium(BKCa)channel modulates vascular smooth muscle *** the present study,we tested the hypothesis that salt,one of the factors which significantly influence blood pressure(BP),can regulate BKCa activity and then elevate blood *** Male Sprague-Dawley rats aged 6 weeks were randomized into high salt diet group(HS)and control group,fed with high salt diet(containing 5% NaCl)and standard rat chow(containing 0.4% NaCl)respectively for 16 *** systolic blood pressure(SBP),body weight(BW)and 24-hour urinary output were tested every 4 *** of urinary Na+ was detected using flame spectrophotometrical *** the end of 16 weeks,all the rats were killed,the mesenteric arteries were obtained,and single mesenteric smooth muscle cells were isolated at *** resting membrane potential(Em),the total potassium currents and the currents after perfusion with TEA solution of the cells were all recorded by whole cell patch *** transcriptions of BKCa channel α and β1 subunits in mesenteric arterial vascular smooth muscle cells(VSMC)of each group were calculated by real-time *** There was no difference in SBP and BW at each stage between control group and HS group;the urinary Na+ level in HS animals was elevated significantly after 4 *** negative values of Em in HS group VSMCs were reduced compared with those in the control *** of β1 subunit of BKCa channels were decreased in HS group,but α subunit transcriptions did not differ between the two *** cell potassium currents did not differ between HS and control groups,but BKCa currents of HS group VSMCs were lower than those of control group *** Even without elevating SBP,salt-loading can still modulate the expression and activity of BKCa channel in the mesenteric arterial VSMC and elevate vascular tone.

关键词： chronic salt-loading large-conductance calcium-activated potassium channel blood pressure

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