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Near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing

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Nano Research 2023年第1期16卷 599-612页

作者： Huiling Zhong Jun Huang Moucheng Luo Yifei Fang Xinchen Zeng Jun Wu Jianhang Du Medical Research Center The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518033China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Department of Liver Surgery The Third People’s Hospital of ShenzhenShenzhen 518112China NHC Key Laboratory of Assisted Circulation Sun Yat-sen UniversityGuangzhou 510080China

Wound ulceration caused by diabetes is a typical chronic wound wherein healing the local tissue is difficult due to lack of blood vessels and tissue necrosis caused by the long-term accumulation of free radicals.Near-field electrospinning(NFES)is an innovative technology used to produce micro-nano-scaled,controllable sequencing fibers.In this study,we constructed a novel wound dressing based on the NFES polycaprolactone(PCL)fiber network and modified gelatin with methacrylic anhydride(GelMA)hydrogel to promote angiogenesis and the re-epithelialization of diabetic wounds.An angiogenic and antioxidant drug named deferoxamine(DFO)was encapsulated in a GelMA hydrogel to achieve a slow-release effect that is more suitable for chronic wounds.The cell adhesion experiment showed that the cells could attach to the fibers in the dressing group having a network of PCL fibers on the surface and grow along the direction of the fibers,which in turn,effectively regulates cell behavior from the physical structure.Additionally,the large pore size(~500μm)of the network allowed the cells to penetrate the pores and enter the surface of the hydrogel without being blocked out.Besides,the composite dressing had a notable effect on angiogenesis.Furthermore,antioxidation experiments confirmed that the DFO-loaded hydrogel exhibited antioxidant activity.Experimental animal models of diabetes showed that rats treated with the PCL-GelMA-DFO(PGD)hydrogel had faster ability of hemostasis,scab formation,and wound healing.In conclusion,the PGD hydrogel effectively promoted the repair of chronic wounds.

关键词： diabetic wound healing near field electrospinning hydrogel large pore

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A novel 3D chiral metal-organic framework with large pores

A novel 3D chiral metal-organic framework with large pores

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中国化学会第十届全国无机化学学术会议

作者： Lei Jia Xiao Geng Zhen Zhang Suo-Shu Zhang Shi-Fen Li Zhe Xue Rong-Rong Zhu Lin Du Qi-Hua Zhao Key Laboratory of Medicinal Chemistry for Natural Resource Education Ministry Yunnan University School of Chemical Science and Technology Pharmacy Yunnan University

A new chiral metal-organic framework with 3D network, [Zn（（R）-CBA）2（4-bpdb）]n（1）, has been synthesized and characterized by single-crystal X-ray diffraction. Complex 1 is a chiral 3D metal-organic framework, which crystallizes in the chiral space group C2, having pretty large pores（Figure 1 a）. To further understand the nature of chirality in this complex, the building block is selected as a fan blade-like unit（Figure 1 b）, showing that four（R）-CBA ligands have right-handedness in the coordination sphere. As far as we know, the chiral nature has a transfer effect, implying that chirality of complex 1 is originated from the chirality of ligand（R）-CBA. Structural investigation reveals that both（R）-CBA and 4-bpdb link metal ions to constructing the interesting 3D framework. For the large pore of this chiral metal-organic framework, it could be expected for asymmetric catalysis and chiral separation, further studies are in progress.

关键词： metal-organic framework chirality large pore

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