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Regulation properties of large-conductance background K+ channels in mouse B cells

Regulation properties of large-conductance background K+ cha...

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2008北京国际生理科学学术大会

作者： NAM Joo Hyun SHIN Dong Hun KIM Sung Joon Department of Physiology Seoul National University College of MedicineSeoul 110-799Korea

K channels like Kv1.3 and SK4 play critical roles in *** mouse B lymphocytes,we have newly found background(voltage-independent)K channels with large conductance(LK,00pS)and medium conductance(MK,～100 pS).LK is negatively regulated by PIP in a membrane-delimited manner,and activated by arachidonic *** the molecular identities are still unclear,the single channel conductance,background activity,and activation by arachidonic acid suggested that the LK is similar with TREK-2,a subgroup of two-pore domain K ***,our preliminary RT-PCR study demonstrated that mRNA for mouse TREK-2 is well expressed in WEHI-231 cells,a murine B cell line representing the immature stage of B cell development. In this study,we studied pH and thermo-sensitivity of LK and MK in *** activated by decreasing intracellular pH(6.8-6.0)while not by extracellular pH *** contrast,MKwas inhibited by intracellular acidification. By wanning bath solution from 25 to 35°C,the activity of LKwas slowly increased by 10 to 20 folds in the cellattached and inside-out ***,the whole-cell K current and the LKactivity of pre-warmed WEHI-231 were only weakly increased,suggesting that the microenvironment for LKmight be changed by warmed temperature in a membrane-delimited *** was not *** LKnor MKwere affected by halothane. These results suggest that,in spite of some similarities,LKand MK are different subgroups of background-type K channels in B *** pH and temperature sensitivity might play a role in the inflammatory conditions and immune reactions.

关键词： K+ channels large conductance B cells

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