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Correlation of the occurrence of YMDD mutations with HBV genotypes,HBV-DNA levels,and HBeAg status in Chinese patients with chronic hepatitis B during lamivudine treatment

引用

Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 172-176页

作者： Feng Wu,Min-Jin Wu,Xiao-Lin Zhuge,Shao-Ming Zhu and Biao Zhu Department of Chinese Pharmacy, Department of Laboratory Medicine , State Key Laboratory for Diagnosis and Treatment of Infectious Diseases , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Department of Chinese Pharmacy First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Department of Laboratory Medicine First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND:Continuous lamivudine therapy is associated with high rates of YMDD mutations,which are the main causes of drug *** current study explores the association of the emergence of YMDD mutations with pretherapy HBV genotype,HBV-DNA levels,HBeAg status,and serum alanine aminotransferase(ALT) levels in Chinese patients receiving lamivudine therapy for chronic hepatitis ***:A total of 319 chronic hepatitis B patients who received lamivudine therapy for more than a year were enrolled in this *** mutations,HBV genotype,HBV-DNA levels,HBeAg status,and ALT levels were determined prior to their lamivudine treatment and every three months for a year of this ***:Among the 319 patients,137(42.95%) were infected with genotype B and 182(57.05%) with genotype *** to 94 patients(29.47%) developed YMDD mutations within one year of lamivudine ***,50 patients with HBV genotype B and 44 patients with genotype C developed YMDD mutations(36.50% vs 24.18%,Ptherapy HBV genotype,HBV-DNA levels,and HBeAg status are independent factors for the emergence of YMDD mutations(HBV genotype:OR=2.159,95% CI 1.291-3.609,P=0.003;HBV-DNA:OR=1.653,95% CI 1.231-2.218,P=0.001;HBeAg:OR=2.021,95% CI 1.201-3.399,P=0.008).CONCLUSIONS:HBV genotype,HBV-DNA levels,and HBeAg status at baseline are the independent factors associated with the emergence of YMDD mutations among Chinese patients receiving lamivudine therapy for chronic hepatitis *** findings are helpful to the development of therapeutic strategies for these patients.

关键词： YMDD mutations lamivudine therapy chronic hepatitis B HBV genotype

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