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Microglia lactylation in relation to central nervous system diseases

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Acid tolerance of lactate-utilizing bacteria of the order Bacteroidales contributes to prevention of ruminal acidosis in goats adapted to a high-concentrate diet

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Animal Nutrition 2023年第3期14卷 130-140页

作者： Zhongyan Lu Lingmeng Kong Shenhao Ren Jorg RAschenbach Hong Shen Key Lab of Animal Physiology and Biochemistry College of Veterinary MedicineNanjing Agricultural UniversityNanjingJiangsuChina College of Life Science Nanjing Agricultural UniversityNanjingJiangsuChina Institute of Veterinary Physiology Freie Universitat BerlinBerlinGermany Bioinformatics Center Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjingJiangsuChina

The rapid accumulation of organic acids,particularly lactate,has been suggested as the main cause of ruminal acidosis(RA)for ruminants fed high-concentrate *** research has shown that a gradual shift from low-to high-concentrate diets within 4 to 5 weeks effectively reduces the risk for ***,the mechanisms remain *** this study,20 goats were randomly allocated into four groups(n=5)and fed with a diet containing a weekly increasing concentrate portion of 20%,40%,60%,and 80%over 28 *** d 7,14,21,and 28,one group(named C20,C40,C60,and C80 according to the last concentrate level that they received)was killed and the ruminal microbiome was *** acidosis was not detected in any of the goats during the ***,ruminal pH dropped sharply from 6.2 to 5.7(Plactate dehydrogenase(nLDH),catalyzing the enzymatic conversion of pyruvate to lactate(Plactate dehydrogenase(iLDH),catalyzing lactate oxidation to pyruvate,showed no significant concomitant *** and expression alterations for nLDH-and iLDH-encoding genes were attributable to bacteria from Clostridiales and Bacteroidales,*** analyzing the gene profiles of 9 metagenome bins(MAG)with nLDH-encoding genes and 5 MAG with iLDH-encoding genes,we identified primary and secondary active transporters as being the major types of sugar transporter for lactate-producing bacteria(LPB)and lactate-utilizing bacteria(LUB),***,more adenosine triphosphate was required for the phosphorylation of sugars to initiate their catabolic pathways in LPB compared to ***,the low dependence of sugar transport systems and

关键词： Ruminal microbiome Ruminal acidosis Acid tolerance lactate metabolism

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Differential expression and function of the endogenous lactate receptor, GPR81, in ERα-positive/HER2-positive epithelial vs. post-EMT triple-negative mesenchymal breast cancer cells

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Journal of Cancer Metastasis and Treatment 2019年第6期4卷 1-14页

作者： Denisse Tafur Patrick Svrcek Bruce White Department of Cell Biology University of Connecticut HealthFarmingtonCT 06032USA University of Connecticut School of Medicine University of Connecticut HealthFarmingtonCT 06032USA.

Aim:lactate can signal through the endogenous lactate receptor,GPR81,which is expressed in some *** metabolism is altered by the metastasis-promoting process of epithelial-mesenchymal transition(EMT).This study examined the expression and function of GPR81 in breast cancer samples,and in receptor-positive epithelial ***-negative post-EMT mesenchymal breast cancer ***:GPR81 mRNA expression was examined by breast cancer microarray,and by a Kaplan-Meier survival *** 3-dimensional culture conditions,GPR81 mRNA expression in epithelial and mesenchymal breast cancer cell lines was measured by ***81 siRNA was used to assess the role of GPR81,alone or in conjunction with tamoxifen,in the regulation of MCT1 and MCT4 lactate transporters,intracellular lactate,and cell proliferation and ***:GPR81 mRNA levels were elevated in receptor-positive breast cancer,relative to non-tumor and triple-negative samples,and correlated with increased ***81 expression was elevated in the two epithelial breast cancer cell lines *** corresponding post-EMT mesenchymal cell ***81 knock-down in epithelial MCF7 cells caused:1,selectively lower mRNA and protein expression of the MCT1 transporter,but not MCT2 or MCT4 ;transporters;2,lower levels of intracellular lactate;and 3,decreased proliferation and survival in lactate only-containing ***81 siRNA plus tamoxifen displayed additive suppressive effects on MCT1 expression and cell ***:GPR81 promotes the ability of epithelial breast cancer cells to import lactate for energy *** such,GPR81 represents a potential target for treatment of hormone-positive breast cancer cells,and may be prognostic for higher grade breast cancer.

关键词： GPR81 lactate metabolism MCT transporters MCT1 tamoxifen

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